Uncertainty-aware soft sensors in sign language recognition (SLR) integrate methods to quantify and manage the uncertainty in their predictions. This is particularly crucial in SLR due to the variability in sign language gestures and differences in individual signing styles. Managing uncertainty allows the system to handle variations in signing styles, lighting conditions, and occlusions more effectively. While current techniques for handling uncertainty in SLR systems offer significant benefits in terms of improved accuracy and robustness, they also come with notable disadvantages. High computational complexity, data dependency, scalability issues, sensor and environmental limitations, and real-time constraints all pose significant hurdles. The aim of the work is to develop and evaluate a Type-2 Neutrosophic Hidden Markov Model (HMM) for SLR that leverages the advanced uncertainty handling capabilities of Type-2 neutrosophic sets. In the suggested soft sensor model, the Foot of Uncertainty (FOU) allows Type-2 Neutrosophic HMMs to represent uncertainty as intervals, capturing the range of possible values for truth, falsity, and indeterminacy. This is especially useful in SLR, where gestures can be ambiguous or imprecise. This enhances the model’s ability to manage complex uncertainties in sign language gestures and mitigate issues related to model drift. The FOU provides a measure of confidence for each recognition result by indicating the range of uncertainty. By effectively addressing uncertainty and enhancing subject independence, the model can be integrated into real-life applications, improving interactions, learning, and accessibility for the hearing-impaired. Examples such as assistive devices, educational tools, and customer service automation highlight its transformative potential. The experimental evaluation demonstrates the superiority of the Type-2 Neutrosophic HMM over the Type-1 Neutrosophic HMM in terms of accuracy for SLR. Specifically, the Type-2 Neutrosophic HMM consistently outperforms its Type-1 counterpart across various test scenarios, achieving an average accuracy improvement of 10%.