Single- Versus Multiple-Fraction Radiation Therapy for Painful Bone Metastases: A Systematic Review and Meta-analysis of Nonrandomized Studies

Saitô, Tetsuo; Yamaguchi, Kohsei; Toya, Ryo; Oya, Natsuo

doi:10.1016/j.adro.2019.06.003

Cited by 11 publications

(13 citation statements)

References 33 publications

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“…38 This is convenient and cost-effective, yet still underused. [39][40][41] In our study, fewer patients had singlefraction treatments, similar to results from a recent Ethiopian study. 42 Several reasons may justify the choice of longer fractionation.…”

Section: Discussionsupporting

confidence: 90%

Patterns of Palliative Radiotherapy Utilization for Patients With Metastatic Breast Cancer in Harare, Zimbabwe

Mushonga

Nyakabau

Ndlovu

et al. 2021

JCO Global Oncology

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PURPOSE In sub-Saharan Africa, radiotherapy (RT) utilization and delivery patterns have not been extensively studied in patients with metastatic breast cancer. METHODS A retrospective cohort study of female patients with metastatic breast cancer seen at Parirenyatwa Radiotherapy Centre in Zimbabwe from 2014 to 2018 was conducted. Demographics, pathology, staging, and treatment data were abstracted through chart review. Fisher's exact test and chi-squared test of independence were used to compare proportions, and independent two-sample t-tests were used to compare means. RESULTS Of 351 patients with breast cancer, 152 (43%) had metastatic disease, median age 51 years (interquartile range: 43-61 years). Of those with metastatic disease, 30 patients (20%) received radiation to various metastatic sites: 16 spine; three nonspine bone metastases; six whole brain; and five chest wall or supraclavicular. Patients who received radiation were younger (46 v 52 years; P = .019), but did not differ significantly by performance status than those who did not. The most common dose prescription was 30 Gy in 10 fractions (33%). Five (17%) patients had treatment interruption and two (7%) had treatment noncompletion. Province of origin and clinical tumor stage were significant predictors of RT receipt ( P = .002; and P = .018, respectively). CONCLUSION A minority of patients with metastatic breast cancer received RT (20%), and these were likely to be younger, with advanced tumor stage, and resided in provinces where RT is available. Conventional courses were generally prescribed. There is a need to strongly consider palliative RT as an option for patients with metastatic breast cancer and use of hypofractionated courses (e.g. 8 Gy in one fraction) may support this goal.

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Section: Discussionsupporting

confidence: 90%

Patterns of Palliative Radiotherapy Utilization for Patients With Metastatic Breast Cancer in Harare, Zimbabwe

Mushonga

Nyakabau

Ndlovu

et al. 2021

JCO Global Oncology

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“…It should be noted that randomised studies and meta-analyses do not show any superiority between these treatment regimens in the management of uncomplicated bone metastases. Moreover, they show that the hypofractionated regimen was more commonly used by experienced radiotherapists [13], [16], [17], [14]. The study by Slotman et al showed that the majority of patients preferred a one-day management [18].…”

Section: Discussionmentioning

confidence: 99%

Analgesic radiation therapy for bone metastasis in Dakar

Ka¹,

Dieng²,

Gaye³

et al. 2021

World J. Adv. Res. Rev.

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Background: Three-dimensional conformal radiotherapy is a new tool in the Senegalese therapeutic arsenal. Symptomatic bone metastases affect the quality of life of patients. Analgesic radiotherapy is proposed to patients to relieve them. Patients and methods: A prospective descriptive study was carried out on all patients with symptomatic bone metastasis. Hypo-fractionated radiotherapy was performed on the painful site. The visual analogue scale was used to assess pain before radiotherapy, 72 hours and one week after. Results: The sex ratio was 0.5. The median age at diagnosis of symptomatic metastasis was 53 years. All patients received 8 Gy (Gray) in one session. A complete response was noted one week post radiotherapy. Conclusion: Analgesic radiotherapy improves the quality of life of patients with symptomatic bone metastasis.

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“…Radiotherapy is an important treatment option for cancer-related pain [1,2]. The pain response rate after radiotherapy for painful various tumors was reportedly 47-80% [3][4][5][6]. Among them, radiotherapy for painful bone metastases, which has been investigated extensively [3,6,7], was strongly recommended by the World Health Organization [8].…”

Section: Introductionmentioning

confidence: 99%

“…The pain response rate after radiotherapy for painful various tumors was reportedly 47-80% [3][4][5][6]. Among them, radiotherapy for painful bone metastases, which has been investigated extensively [3,6,7], was strongly recommended by the World Health Organization [8]. However, there are few studies of palliative radiotherapy for painful tumors other than bone metastases [9].…”

Section: Introductionmentioning

confidence: 99%

Palliative radiotherapy for painful lymph node metastases

Yamaguchi

Saitô²,

Toya

et al. 2021

Radiat Oncol

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Background There is limited evidence concerning radiotherapy for painful lymph node metastases (PLM). We evaluated the effectiveness of radiotherapy for PLM using the International Consensus Endpoint in a subgroup analysis of a prospective observational study. Methods In the primary study, 302 patients received radiotherapy for painful tumors. Among them, those treated with palliative radiotherapy for PLM were analyzed in the present study. We used the Brief Pain Inventory short form to evaluate the intensity of pain and the pain interference in patient's life. We collected the Brief Pain Inventory and analgesic data at baseline and at 1, 2, and 3 months after the start of radiotherapy. Pain response was assessed using the International Consensus Endpoint. Patients were diagnosed with a predominance of other pain (POP) if non-index pain of a malignant or unknown origin was present and had a greater 'worst pain' score than the index pain. Results Radiotherapy for PLM was performed on 25 patients. In total, 15 (60%) patients experienced a pain response. The pain response rates for evaluable patients were 66%, 67%, and 57% at 1-, 2-, and 3-month follow-ups, respectively. At baseline and at 1, 2, and 3 months, the median index pain scores were 7, 2, 0, and 0.5, respectively. At 1 month, all pain interference scores were significantly reduced from baseline. Four (16%) patients experienced POP within three months. Conclusion Radiotherapy for PLM improved pain intensity and pain interference. Palliative radiotherapy may be a viable treatment option for PLM.

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Single- Versus Multiple-Fraction Radiation Therapy for Painful Bone Metastases: A Systematic Review and Meta-analysis of Nonrandomized Studies

Cited by 11 publications

References 33 publications

Patterns of Palliative Radiotherapy Utilization for Patients With Metastatic Breast Cancer in Harare, Zimbabwe

Patterns of Palliative Radiotherapy Utilization for Patients With Metastatic Breast Cancer in Harare, Zimbabwe

Analgesic radiation therapy for bone metastasis in Dakar

Palliative radiotherapy for painful lymph node metastases

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