Single vs. double phototherapy in the treatment of full-term newborns with nonhemolytic hyperbilirubinemia

Silva, Ignacia; Luco, Matías; Tapia, José Luís; Pérez, María Eugenia; Salinas, José Antonio; Flores, Javiera; Villaroel, Luis

doi:10.2223/jped.1927

Cited by 14 publications

(15 citation statements)

References 13 publications

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“…The present study results were also supported by the findings of Silva et al 11 His findings suggest that at higher levels of bilirubin double surface phototherapy group was more effective when compared to the single surface phototherapy. Some studies have compared conventional phototherapy unit with fiber optic units.…”

Section: Resultssupporting

confidence: 91%

Comparison of effectiveness of light emitting diode phototherapy with conventional phototherapy and combination phototherapy of conventional with fiberoptic biliblanket, and light emitting diode phototherapy with fiber optic biliblanket for treatment of neonatal hyperbilirubinemia

Yenamandra

Kumar

Garg

et al. 2018

Int J Contemp Pediatr

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Background: Hyperbilirubinemia is a common problem in neonates with an incidence of 70-80%. Phototherapy is the preferred method of treatment for neonatal hyperbilirubinemia by virtue of its noninvasive nature and its safety. LED phototherapy, conventional phototherapy and fiber optic phototherapy are the modalities used in management of nonhemolytic hyperbilirubinemia in the first week of life in healthy near term and term neonates. The present study was conducted with the objective to compare effectiveness of double surface light emitting diode phototherapy with conventional double surface phototherapy and combination phototherapy of conventional and fiberoptic biliblanket, and light emitting diode phototherapy with fiber optic biliblanket for treatment of neonatal hyperbilirubinemia.Methods: Total of 236 neonates with hyperbilirubinemia were prospectively randomized to four groups to receive single surface conventional and fiber optic biliblanket combination phototherapy (n=60; Group-1), double surface LED phototherapy (n=59; Group-2), fiber optic biliblanket and single surface LED phototherapy groups (n=62; Group-3) and double surface conventional phototherapy group (n=55; Group-4). Bilirubin levels were measured at different time intervals and adverse effects were noted if any.Results: The rate of percentage and overall decrease of bilirubin was best in Group-2 (48.27%; 8.6 mg%) followed by Group-4 (45.49%; 8.1 mg%), Group-3 (41.26%; 7.27 mg%) and Group-1 (39.37%; 6.9 mg%). None of the babies presented side effects in Group-1 and Group-3. Neonates in Group-4 had shown loose stools (n=1), skin rash (n=3) and hyperthermia (n=2). Hyperthernia and skin rash was found in each case in Group-2.Conclusions: Rate of decrease of bilirubin was best in double surface LED phototherapy followed by double surface conventional phototherapy, fiber optic biliblanket with single surface LED combination phototherapy and fiber optic biliblanket and single surface conventional phototherapy.

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Section: Resultssupporting

confidence: 91%

Comparison of effectiveness of light emitting diode phototherapy with conventional phototherapy and combination phototherapy of conventional with fiberoptic biliblanket, and light emitting diode phototherapy with fiber optic biliblanket for treatment of neonatal hyperbilirubinemia

Yenamandra

Kumar

Garg

et al. 2018

Int J Contemp Pediatr

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“…A large number of the causes of hyperbilirubinemia in full-term neonates are benign and reversible and do not need therapeutic intervention. 1,2 The most feared toxic effect, potentially irreversible and secondary to hyperbilirubinemia, is bilirubin encephalopathy, also known as kernicterus. [1][2][3][4] The main treatment for jaundice is performed using phototherapy, following the criteria recommended by the American Academy of Pediatrics.…”

mentioning

confidence: 99%

Side Effects of Phototherapy on Neonates

2018

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Phototherapy in neonates for treatment of pathological jaundice is an effective therapeutic tool that is widely used in neonatal units. Over the past years, a greater concern has emerged about the effects on the immune and inflammatory system and its potential genotoxic and side effects, especially the late ones, possibly associated with childhood diseases, showing that this treatment is not as harmless as previously believed. Numerous studies assessing these possible adverse effects of phototherapy on neonates have been published over the past years. Through this review, we seek to analyze what we know about the side effects of phototherapy in the neonatal period. The main causes of jaundice, phototherapy techniques, acute and late side effects, and effects on the immune and inflammatory system were reviewed. It was concluded that phototherapy is not a treatment free of side effects and further studies need to be conducted to elucidate its harmful effects on neonates.

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“…In Table 2, we summarize the other recent RCTs (21–37), i.e., the RCTs published between 2008 up to and including 2010. These studies focussed on diagnostic aspects such as TcB measurements (21,22) as well as treatment strategies including PT (23–30), prebiotics (31) or pharmacological treatment, i.e., treatment with drugs (32–35) and Chinese herbs (36,37). It is interesting to note that increasingly these clinical trials are being conducted in non‐Western countries.…”

Section: Resultsmentioning

confidence: 99%