This study was designed to examine the effects of a 12-week resistance training program using single versus multiple sets of a complex versus simple exercise on EMG, strength and regional body composition. Twenty-eight untrained men ( n=15) and women ( n=13) performed resistance training twice per week. Group 1 (S-1, n=9) performed one set of a leg press (LP) and bicep curl (BC) exercise, group 2 (M-6, n=9) performed six sets of a LP and BC exercise, and group 3 (C, n=10) was the control group. One-repetition maximums (1RMs) and EMG were measured in the LP and BC during pre-, mid-, and post-training. Lean body mass of the legs and arms were measured pre- and post-training by dual energy X-ray absorptiometry. Results of the study indicated that both S-1 and M-6 groups significantly increased percentage strength pre- to post-training in both the LP and BC [S-1 pre-/post-LP=41.2 (23.7)%, BC=8.5 (6.71)%; M-6 pre-/post-LP=52.6 (12.6)%, BC=22.8 (15.6)%; mean (SD)]. However, compared to S-1, M-6 showed a significantly greater increase in percentage strength in the BC ( P