Single wall carbon nanotube electrode system capable of quantitative detection of CD4+ T cells

Kim, Joonhyub; Park, Gayoung; Lee, Seoho; Hwang, Suk Won; Min, Nam Ki; Lee, Kyung Mi

doi:10.1016/j.bios.2016.11.055

Cited by 29 publications

(11 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies also obtained a similar tendency of alterations in the spleen index and thymus index as in our research . The CD8 and CD4 glycoproteins are two major subsets of T lymphocytes . CD8 + T cells play a critical role in human antitumor immunity .…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Improved antitumor activity of cisplatin combined with Ganoderma lucidum polysaccharides in U14 cervical carcinoma‐bearing mice

Zhu

Jiang

et al. 2019

The Kaohsiung J of Med Scie

View full text Add to dashboard Cite

Research on anticervical cancer is urgently required to enhance clinical outcomes. As a main anticancer drug for cervical carcinoma, cisplatin (CIS) has been used for a lot of years in clinical therapy. However, serious adverse effects including nephrotoxicity and neurotoxicity limit its long‐term treatment. Our main goal of this study is to investigate the improvement of Ganoderma lucidum polysaccharides (GPS) on CIS‐induced antitumor effect of in U14 cervical carcinoma‐bearing mice. The results showed that GPS + CIS could not only inhibit the growth of the tumor but also improve the spleen and thymus indexes. Moreover, little toxicological effects were observed on hepatic function and renal function in GPS + CIS treated mice bearing U14 tumor cells. Further analysis of the tumor inhibition mechanism indicated that the number of apoptotic tumor cells increased significantly, the expression of Bax increased and the expression of Bcl‐2 decreased dramatically in cervical cancer sections after oral administration of GPS + CIS for 14 days. This GPS/CIS combined therapy represents intriguing therapeutic strategy for U14 cervical carcinoma providing not only superior efficacy but also a higher safety level.

show abstract

Section: Discussionmentioning

confidence: 99%

“…20,21 The CD8 and CD4 glycoproteins are two major subsets of T lymphocytes. 22 CD8 + T cells play a critical role in human antitumor immunity. 23 CD4 + T cells could activate and recruit innate immune cells including macrophages and natural killer cells in human antitumor immunity.…”

Section: Discussionmentioning

confidence: 99%

Improved antitumor activity of cisplatin combined with Ganoderma lucidum polysaccharides in U14 cervical carcinoma‐bearing mice

Zhu

Jiang

et al. 2019

The Kaohsiung J of Med Scie

View full text Add to dashboard Cite

show abstract

“…By using CNT-based sensors, the sensing of volatile organic compounds related to human diseases is demonstrated [24], glucose oxidase (GOD) sensing using CNT is performed [25], and the extraordinary low detection limit of CNT working electrodes is shown [26]. Producing biosensors using CNT is an emerging trend.…”

Section: Introductionmentioning

confidence: 99%

[Retracted] Computational Investigations of Fixed‐Free and Fixed‐Fixed Types Single‐Wall Carbon Nanotube Mass Sensing Biosensor

Umapathi¹,

Sangeetha

Shankar

et al. 2021

Advances in Materials Science and Engineering

View full text Add to dashboard Cite

Using carbon nanotubes for sensing the mass in a biosensor is recently proven as an emerging technology in healthcare industry. This study investigates relative frequency shifts and sensitivity studies of various biological objects such as insulin hormone, immunoglobulin G (IgG), the most abundant type of antibody, and low-density lipoproteins (LDL) masses using the single-wall carbon nanotubes as a biomass sensor via continuum mechanics. Uniform distributed mass is applied to the single-wall carbon nanotube mass sensor. In this study, fixed-free and fixed-fixed type single-wall carbon nanotubes with various lengths of relative frequency shifts are studied. Additionally, the sensitivity analysis of fixed-free and fixed-fixed type CNT biological mass sensors is carried out. Moreover, mode shapes studies are performed. The sensitivity results show better, if the length of the single-wall carbon nanotube is reduced.

show abstract

“…The two major subsets of T lymphocytes are defined by expression of CD4 or CD8 glycoproteins respectively [ 20 ]. CD8 + T cells play an important role in orchestrating the antitumor response by imparting cytolytic activity and cytokine expression.…”

Section: Resultsmentioning

confidence: 99%

Antitumor and Immunoregulatory Activities of Seleno-β-Lactoglobulin on S180 Tumor-Bearing Mice

et al. 2017

View full text Add to dashboard Cite

Degeneration of immune organs like thymus and spleen has been discovered in tumor-bearing mice; which increases the difficulties on oncotherapy. More effective drugs which target the protection of immune organs are expected to be researched. In this study; we aim to analyze the antitumor and immunoregulatory activities of seleno-β-lactoglobulin (Se-β-lg) on S180 tumor-bearing mice. Results indicated that Se-β-lg exhibited a remarkable inhibitory effect on S180 solid tumors with the inhibition rate of 48.38%; and protected the thymuses and spleens of S180-bearing mice. In addition, Se-β-lg could also balance the proportions of CD4+ and CD8+ T cells in spleens; thymuses and peripheral bloods; and improve Levels of IL-2; IFN-γ; TNF-α in mice serums. β-lg showed weaker bioactivities while SeO2 showed stronger toxicity on mice. Therefore our results demonstrated that Se-β-lg possessed stronger antitumor and immunoregulatory activities with lower side effects and had the potential to be a novel immunopotentiator and antitumor agent.

show abstract

Single wall carbon nanotube electrode system capable of quantitative detection of CD4+ T cells

Cited by 29 publications

References 38 publications

Improved antitumor activity of cisplatin combined with Ganoderma lucidum polysaccharides in U14 cervical carcinoma‐bearing mice

Improved antitumor activity of cisplatin combined with Ganoderma lucidum polysaccharides in U14 cervical carcinoma‐bearing mice

[Retracted] Computational Investigations of Fixed‐Free and Fixed‐Fixed Types Single‐Wall Carbon Nanotube Mass Sensing Biosensor

Antitumor and Immunoregulatory Activities of Seleno-β-Lactoglobulin on S180 Tumor-Bearing Mice

Contact Info

Product

Resources

About