Single walled carbon nanohorns as photothermal cancer agents

Whitney, Jon; Sarkar, Sandipan; Zhang, Jianfei; Do, Thao; Young, Taylor T.; Manson, Mary Kyle; Campbell, Thomas A.; Puretzky, Alexander A.; Rouleau, Christopher M.; More, Karren L.; Geohegan, David B.; Rylander, Christopher G.; Dorn, Harry C.; Rylander, Marissa Nichole

doi:10.1002/lsm.21025

Cited by 73 publications

(65 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the thermal conductivity of the solution is increased in higher concentrations, which dissipates more heat and thus makes the temperature drop slightly for higher concentrations. This maximum was not observed for our high laser power experiment (500 mW/cm 2 ) and in other studies that used higher laser power densities of 2 -4 W/ cm 2 and 40 W/cm 2 [24,26]. This might be because the heat dissipation effect of the thermal conductivity increasing occurred before the laser depletion, thus no maximum appeared.…”

Section: Figurecontrasting

confidence: 64%

“…They found that the solution temperature was increased for 1, 5, 10, 25 and 50 μg/ml, and saturated at 75 and 100 μg/ml. Whitney et al, [26] studied single-walled carbon nanohorns heated with a c.w. laser at wavelength 1064 nm and irradiance of 40 W/cm 2 for duration of 0-6 minutes.…”

Section: Figurementioning

confidence: 99%

“…Most of the studies involving SWNTs or other nanoparticles-assisted photothermal treatment were based on high laser power density of 1-40 W/cm 2 [23][24][25][26][27][28]. However, high laser power density could cause non-selective photothermal damage to the surrounding normal tissues.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Photothermal Effect of PEG-Functionalized Single-Walled Carbon Nanotubes

Zeng¹

2017

NTMB

View full text Add to dashboard Cite

Section: Figurecontrasting

confidence: 64%

Section: Figurementioning

confidence: 99%

See 1 more Smart Citation

Photothermal Effect of PEG-Functionalized Single-Walled Carbon Nanotubes

Zeng¹

2017

NTMB

View full text Add to dashboard Cite

“…They are novel nanostructure carbon materials generating much enthusiasm in biomedical applications, such as drug delivery, photo-hyperthermia (due to their intrinsic therapeutic effects), and magnetic resonance analysis, due to their several advantages over other carbon materials such as single-walled carbon nanotubes. [1][2][3][4][5][6][7][8][9][10][11][12] Besides their high purity, uniform size, and absence of metal catalysts, they have an extremely large specific surface area. 8 Furthermore, their surface area can be enlarged, holes can be opened, and oxygen functional groups can be introduced by oxidation at their …”

Section: Introductionmentioning

confidence: 99%

The interactions of single-wall carbon nanohorns with polar epithelium

Shi¹,

Shi

Li³

et al. 2017

IJN

View full text Add to dashboard Cite

Single-wall carbon nanohorns (SWCNHs), which have multitudes of horn interstices, an extensive surface area, and a spherical aggregate structure, offer many advantages over other carbon nanomaterials being used as a drug nanovector. The previous studies on the interaction between SWCNHs and cells have mostly emphasized on cellular uptake and intracellular trafficking, but seldom on epithelial cells. Polar epithelium as a typical biological barrier constitutes the prime obstacle for the transport of therapeutic agents to target site. This work tried to explore the permeability of SWCNHs through polar epithelium and their abilities to modulate transcellular transport, and evaluate the potential of SWCNHs in drug delivery. Madin-Darby canine kidney (MDCK) cell monolayer was used as a polar epithelial cell model, and as-grown SWCNHs, together with oxidized and fluorescein isothiocyanate-conjugated bovine serum albumin-labeled forms, were constructed and comprehensively investigated in vitro and in vivo. Various methods such as transmission electron microscopy and confocal imaging were used to visualize their intracellular uptake and localization, as well as to investigate the potential transcytotic process. The related mechanism was explored by specific inhibitors. Additionally, fast multispectral optoacoustic tomography imaging was used for monitoring the distribution and transport process of SWCNHs in vivo after oral administration in nude mice, as an evidence for their interaction with the intestinal epithelium. The results showed that SWCNHs had a strong bioadhesion property, and parts of them could be uptaken and transcytosed across the MDCK monolayer. Multiple mechanisms were involved in the uptake and transcytosis of SWCNHs with varying degrees. After oral administration, oxidized SWCNHs were distributed in the gastrointestinal tract and retained in the intestine for up to 36 h probably due to their surface adhesion and endocytosis into the intestinal epithelium. Overall, this comprehensive investigation demonstrated that SWCNHs can serve as a promising nanovector that can cross the barrier of polar epithelial cells and deliver drugs effectively.

show abstract

“…Nanocarbons, such as carbon nanotubes (CNTs) and carbon nanohorn (CNH), are considered useful in science and technology because of their remarkable physical and chemical properties, some of which might help overcome the limitations of traditional laser light technologies. In particular, nanocarbons have extraordinary photothermal energy conversion efficiency and high absorption cross-sections in a wavelength range capable of transmission within the diagnostic window (21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38). Although gold nanoparticles also have such photothermal properties, nanocarbons can be more effectively heated at various wavelengths because of their strong absorbance over a wide range of the optical region (38).…”

mentioning

confidence: 99%

Photothermic regulation of gene expression triggered by laser-induced carbon nanohorns

Miyako

Deguchi

Nakajima

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

The development of optical methods to control cellular functions is important for various biological applications. In particular, heat shock promoter-mediated gene expression systems by laser light are attractive targets for controlling cellular functions. However, previous approaches have considerable technical limitations related to their use of UV, short-wavelength visible (vis), and infrared (IR) laser light, which have poor penetration into biological tissue. Biological tissue is relatively transparent to light inside the diagnostic window at wavelengths of 650–1,100 nm. Here we present a unique optical biotechnological method using carbon nanohorn (CNH) that transforms energy from diagnostic window laser light to heat to control the expression of various genes. We report that with this method, laser irradiation within the diagnostic window resulted in effective heat generation and thus caused heat shock promoter-mediated gene expression. This study provides an important step forward in the development of light-manipulated gene expression technologies.

show abstract

Single walled carbon nanohorns as photothermal cancer agents

Abstract: The significant increases in absorption, temperature elevation, and cell death with inclusion of SWNHs in laser therapy demonstrate the potential of their use as agents for enhancing photothermal tumor destruction.

Cited by 73 publications

References 40 publications

Photothermal Effect of PEG-Functionalized Single-Walled Carbon Nanotubes

Photothermal Effect of PEG-Functionalized Single-Walled Carbon Nanotubes

The interactions of single-wall carbon nanohorns with polar epithelium

Photothermic regulation of gene expression triggered by laser-induced carbon nanohorns

Contact Info

Product

Resources

About