Single-walled carbon nanotubes as drug carrier loaded with moroxydine hydrochloride against infectious spleen and kidney necrosis virus in mandarin fish

Zhao, Zhao; Ma, Rui; Guo, Zi‐Rao; Zhang, Chen; Xiong, Yan; Wang, Gao‐Xue; Zhu, Bin

doi:10.1016/j.aquaculture.2021.736469

Cited by 7 publications

(2 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…N-hydroxysuccinimide (NHS) conjugation chemistry has been used the most in recent years to conjugate small molecules to nanoparticles. [53,54] For example, You et al conjugated the anticancer drug doxorubicin (DOX) to carboxylated mesoporous silica nanorods via 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC)/NHS conjugation. [53] They showed substantial improvement in key parameters such as DOX half-life, maximum observed concentration, and clearance rate in in vivo mouse models, favorable biodistribution and accumulation in tumors, and reduced tumor volumes compared to free DOX.…”

Section: Small Molecule Drug Attachmentmentioning

confidence: 99%

“…N‐hydroxysuccinimide (NHS) conjugation chemistry has been used the most in recent years to conjugate small molecules to nanoparticles. [ 53,54 ] For example, You et al. conjugated the anticancer drug doxorubicin (DOX) to carboxylated mesoporous silica nanorods via 1‐ethyl‐3‐(3‐dimethylaminopropyl)carbodiimide (EDC)/NHS conjugation.…”

Section: Attachment Chemistries For Nanoparticle Cargo Delivery Systemsmentioning

confidence: 99%

See 1 more Smart Citation

Nanomaterial Strategies for Delivery of Therapeutic Cargoes

Ledesma

Ozcan

Sun

et al. 2021

Adv Funct Materials

View full text Add to dashboard Cite

Over the last decade, much progress has been made in developing nanoparticle-mediated delivery systems to overcome the limitations of existing in vivo delivery technologies. However, the balance between efficacy and safety continues to limit the clinical translation of nanoscale delivery systems. Furthermore, optimizing delivery efficiency requires tuning nanoparticle type and attachment chemistry, both of which are dependent on the cargo being delivered. While the delivery of protein therapeutics is of particular interest, the complexity inherent to protein cargo introduces additional challenges for cargo loading and stabilization. Advances needed for efficient and safe in vivo nanoparticle delivery systems should prioritize design strategies that co-optimize safety, biodegradability, and covalent functionalization. In this review, the most commonly used non-viral nanoparticles are outlined for delivery of small molecule drug, nucleic acid, and protein therapeutic cargoes and potential strategies are discussed for rationally designing nanoparticle-mediated delivery systems.

show abstract

Section: Small Molecule Drug Attachmentmentioning

confidence: 99%

Section: Attachment Chemistries For Nanoparticle Cargo Delivery Systemsmentioning

confidence: 99%