Single-Walled Carbon Nanotubes Enhance Near-Infrared Region Photothermal Therapy

Feifan, 周非凡 Zhou; Da, 邢达 Xing; Sheng, 宋盛 Song; Zhongmin, 欧忠敏 Ou; Wei, 陈伟 Chen

doi:10.3788/cjl20093610.2676

Cited by 2 publications

(1 citation statement)

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“…This allows greater penetration into biological tissue, allowing an effective external activation route for materials capable of strongly transducing such wavelengths to heat. A range of photothermal agents including GO, rGO, carbon nanotubes (CNTs), molybdenum disulfide (MoS 2 ) and gold nanoparticles/gold nanorods (GNPs/GNRs) have been explored with varying degrees of success for roles such as thermal ablation of tissue cells, with a focus on materials with a strong NIR absorbance profile [10,[25][26][27][28][29]. Graphene has a strong absorption coefficient in the NIR and is likely to be a more efficient photothermal transducer than many of the materials previously explored [30].…”

Section: Introductionmentioning

confidence: 99%

Surfactant-exfoliated graphene as a near-infrared photothermal ablation agent

Quinn

Wang

Notley

2018

Biomed. Phys. Eng. Express

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The near-infrared photothermal ability of pristine surfactant-exfoliated graphene was studied and demonstrated through the thermal ablation of mammalian NG108-15 cells. The graphene microsheets were prepared with polyethylene glycol triblock surfactants to improve biocompatibility while achieving high yields using a scalable and low-cost production method without the need for costly and time-consuming purification steps. The cytotoxicity of the surfactant-coated graphene was studied and it showed moderate toxicity. The ability of the exfoliated graphene to withstand extreme temperature cycling was demonstrated, highlighting the suitability of this material for multiple thermal ablation exposures. The pristine nature of the graphene sheets results in greater absorption in the near-infrared compared with graphene oxide or reduced graphene oxide. The photothermal transduction efficiency was also enhanced and determined to be ≈80% at 808 nm leading to the high efficacy of pristine graphene as an ablation agent.

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