Single-walled carbon nanotubes–G-quadruple hydrogel nanocomposite matrixes for cell support applications

Ursu, Elena-Laura; Gavril, Gabriela; Morariu, Simona; Pinteală, Mariana; Barboiu, Mihail; Rotaru, Alexandru

doi:10.1016/j.msec.2020.110800

Cited by 8 publications

(14 citation statements)

References 38 publications

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“…46,47 Furthermore, we have previously highlighted the promising potential of G4-based hydrogels in effectively dispersing and stabilizing variable quantities of SWNTs, resulting in a significant enhancement of the hydrogels' mechanical properties. 48 Herein, we report on successful incorporation of controlled amounts of GO and SWNTs into the G4 hydrogels containing β-CD, resulting in two distinct sets of composite hydrogels with a variable content of nanomaterials. The hydrogel matrix was prepared in a two-step procedure by reacting 1 equiv of benzene-1,4-diboronic acid and β-CD in the presence of KOH, followed by the reaction with the equivalent amount of guanosine.…”

Section: Introductionmentioning

confidence: 99%

Photothermal Hydrogel Composites Featuring G4-Carbon Nanomaterial Networks for Staphylococcus aureus Inhibition

Sardaru,

Rosca,

Ursu

et al. 2024

ACS Omega

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Microbial infections represent a significant health risk, often leading to severe complications and, in some cases, even fatalities. As a result, there is an urgent need to explore innovative drug delivery systems and alternative therapeutic techniques. The photothermal therapy has emerged as a promising antibacterial approach and is the focus of this study. Herein, we report the successful synthesis of two distinct supramolecular composite hydrogels by incorporating graphene oxide (GO) and single-walled carbon nanotubes (SWNTs) into guanosine quadruplex (G4) based hydrogels containing covalently bound β-cyclodextrin (β-CD). The G4 matrix was synthesized through a two-step process, establishing a robust network between G4 and β-CDs, followed by the encapsulation of either GO or SWNTs. Comprehensive characterization of these composite hydrogels were conducted using analytical techniques, including circular dichroism, Raman spectroscopy, rheological investigations, X-ray diffraction, and scanning electron microscopy. A notable discovery from the conducted research is the differential photothermal responses exhibited by the hydrogels when exposed to near-infrared laser irradiation. Specifically, SWNT-based hydrogels demonstrated superior photothermal performance, achieving a remarkable temperature increase of up to 52 °C, in contrast to GO-based hydrogels, which reached a maximum of 34 °C. These composite hydrogels showed good cytotoxicity evaluation results and displayed synergistic antibacterial activity against Staphylococcus aureus, positioning them as promising candidates for antibacterial photothermic platforms, particularly in the context of wound treatment. This study offers a valuable contribution to the development of advanced and combined therapeutic strategies for combating microbial infections and highlights the potential of carbon nanomaterial-enhanced supramolecular hydrogels in photothermal therapy applications.

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Section: Introductionmentioning

confidence: 99%

Photothermal Hydrogel Composites Featuring G4-Carbon Nanomaterial Networks for Staphylococcus aureus Inhibition

Sardaru,

Rosca,

Ursu

et al. 2024

ACS Omega

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“…The goal of this work is to evaluate the status quo, as evidenced by expert opinions in the field, to narrow the topic, and to isolate and underline the impact of these tools on the resulting architectures and following bio-related potential. Although our research spans diverse topics, from bioagents’ carriers, biosynthesis [ 9 , 10 , 11 ], genotypic mapping [ 12 , 13 , 14 , 15 , 16 ], and cell growth [ 17 , 18 ], to artificial water channels [ 19 , 20 , 21 , 22 ], and the exploration of investigative methods [ 23 , 24 ], the review considers the hot topics of drug and gene delivery, antioxidants development, and bioimaging. We addressed these topics by following five major themes: (i) temperature- and pH-responsive systems; (ii) glycodynameric frameworks; (iii) polymeric non-viral vectors; (iv) metallic nanoconjugates; and, (v) smart organic tools.…”

Section: Introductionmentioning

confidence: 99%

Smart Supra- and Macro-Molecular Tools for Biomedical Applications

2020

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Stimuli-responsive, “smart” polymeric materials used in the biomedical field function in a bio-mimicking manner by providing a non-linear response to triggers coming from a physiological microenvironment or other external source. They are built based on various chemical, physical, and biological tools that enable pH and/or temperature-stimulated changes in structural or physicochemical attributes, like shape, volume, solubility, supramolecular arrangement, and others. This review touches on some particular developments on the topic of stimuli-sensitive molecular tools for biomedical applications. Design and mechanistic details are provided concerning the smart synthetic instruments that are employed to prepare supra- and macro-molecular architectures with specific responses to external stimuli. Five major themes are approached: (i) temperature- and pH-responsive systems for controlled drug delivery; (ii) glycodynameric hydrogels for drug delivery; (iii) polymeric non-viral vectors for gene delivery; (iv) metallic nanoconjugates for biomedical applications; and, (v) smart organic tools for biomedical imaging.

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confidence: 97%

“…25,26 The observed cell viability data correlate with those of the previously reported systems containing Li + , benzene-1,4-diboronic acid and G at similar concentrations. 16 The KCl utilized in all DGH samples should not alter the cell viability values due to the relatively low amounts (up to 90 mM), compared to the reported K + extracellular concentrations in in vitro investigations. 27 The fluorescence microscopy images performed after 48 hours of incubation presented the NHDF cells' successful adherence to all three investigated sample surfaces, with cells actively migrating within the hydrogel volume and creating extended cellular projections, particularly observed on DGH1 and DGH2 (Fig.…”

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confidence: 97%

“…15 We recently reported reinforcement of G4-based hydrogels by dispersing single-walled carbon nanotubes as scaffolding pillars for the G4 matrix. 16 The guanosine nucleoside reacted with benzene-1,4-diboronic acid to form anionic diesters able to self-assemble into a G4 extensive network in the presence of K + . The hydrophobic nature of guanosine in the network permitted stabilization of individual carbon nanotubes, thus considerably improving the hydrogel porosity and the amount of entrapped water molecules by the hydrogel.…”

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confidence: 99%

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