Singlet oxygen species and systemic lupus erythematosus: a brief review

Ahmad, Rizwan; Ahsan, Haseeb

doi:10.1080/15321819.2019.1616555

Cited by 24 publications

(24 citation statements)

References 33 publications

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“…Literature supports the fact that along with many other factors, excessive ROS production might be one of the inducers for SLE. 36 Indeed, multiple reports had stated that SLE T-cells exhibit persistently high ROS levels. 5 , 37 Neutrophiles derived from active SLE patients were also found to exhibit altered ROS levels.…”

Section: Discussionmentioning

confidence: 99%

Altered redox regulation by Nrf2-Keap1 system in dendritic cells of systemic lupus erythematosus patients

Gautam

Kaur

Tandon

et al. 2020

Lupus

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Systemic lupus erythematosus (SLE) is an autoimmune disorder associated with inflammation and multiple organ involvement. Individually, dendritic cells (DCs) and oxidative stress have been well discussed for their critical involvement in the pathogenesis of disease but the precise impact of oxidative stress on DCs in relation to SLE disease activity is yet to be scrutinized. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2)/Kelch-like ECH-associated protein 1 (Keap1) pathway is the cellular mechanism to combat increased reactive oxygen species (ROS). The current study was framed in order to understand redox regulation in DCs along with an argument in context to disease activity. Here, 23 SLE patients along with 10 healthy controls were enrolled and disease activity was calculated as the recent change in SLEDAI score. We found the percentage of circulating plasmacytoid DCs (pDCs) was increased with an increase in disease activity. Altered DCs functionality along with disease activity was further supported with the differential concentration of Type I IFNs. The disease activity was positively associated with increased levels of ROS. A relevant reason for increased ROS was further explained with the decreased levels of transcription factor Nrf2. Hence, the present study suggests that SLE specific DCs displayed elevation in ROS and this outcome might be due to impaired free radical clearance by Nrf2. Correlation studies further established an association of disease activity with increased ROS, Type I IFNs levels and decreased activity of oxidative stress regulating enzymes.

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Section: Discussionmentioning

confidence: 99%

Altered redox regulation by Nrf2-Keap1 system in dendritic cells of systemic lupus erythematosus patients

Gautam

Kaur

Tandon

et al. 2020

Lupus

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“…Additionally, the combination of two molecules of ROOH leads to the formation of a very strong oxidant 1 O 2 , similar to the reaction of ROOH with superoxide radical [25]:…”

Section: The Generation Mechanisms Of Reactive Oxygenmentioning

confidence: 96%

Crosstalk between oxidative stress and ocular diseases

Valle¹,

Noblet²,

Martı́nez-Sánchez³

2020

J Clin Res Ophthalmol

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and peroxynitrite (ONOO  ) commonly known as Reactive Oxygen Species (ROS) [3,[6][7][8]. OS may lead to disturbance in the normal oxidation-reduction state of a cell resulting in adaptationresolving oxidant tone (eustress) or damage of the cellular components (distress). Related literature indicates that OS is involved in several human diseases, such as infl ammation, diabetes, arteriosclerosis, autoimmune disorders, skin diseases, hypertension, cancer, eye diseases, infectious diseases, among others [3,8-15]. Over the past decades, the OS theory has strongly stimulated interest in the role of antioxidant defense mechanisms in removing ROS, i.e. antioxidant enzymes and non-enzymatic antioxidants [13]. Concerns have been raised about the benefi ts of the regular physical activity of moderate intensity as the factor linked with adaptation of cells to OS and the ability to enhance the cell antioxidant system[16]. According to the World Health Organization report [17], about 347 million people were suffering from visual impairment worldwide in 2018. Among them, 46 million faced blindness and 300 millions suffered from moderate to severe vision impairments. The knowledge of the role of OS in the etiology of eye diseases, including cancer, mechanisms responsible for the

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“…many years before clinical disease onset. The detection of antinuclear antibodies (ANA) has long been an important tool in the early diagnosis of autoimmune connective tissue diseases [21][22][23][24][25]. Antinuclear antibodies are detected in a substantial population, yet few individuals are diagnosed with the autoimmune disease, although some ANA-positive healthy individuals eventually develop clinical autoimmunity [26].…”

Section: Multiplex Immunoassays For Autoimmune Diseases (Ad)mentioning

confidence: 99%

Multiplex Technology for Biomarker Immunoassays

Ahsan¹,

Ahmad²

2021

Innate Immunity in Health and Disease

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The simultaneous measurement of different substances from a single sample is an emerging area for achieving efficient and high-throughput detection in several applications. Although immunoanalytical techniques are established and advantageous over alternative screening analytical platforms, one of the challenges for immunoassays is multiplexing. While ELISA is still commonly used to characterise a single analyte, laboratories and organisations are moving towards multiplex immunoassays. The validation of novel biomarkers and their amalgamation into multiplex immunoassays confers the prospects of simultaneous measurement of multiple analytes in a single sample, thereby minimising cost, time and sample. Therefore, the technological advancement in clinical sciences is helpful in the identification of analytes or biomarkers in test samples. However, the analytical bioanalysers are expensive and capable of detecting only a small amount or type of analytes. The simultaneous measurement of different substances from a single sample called multiplexing has become increasingly important for the quantification of pathological or toxicological samples. Although multiplex assays have many advantages over conventional assays, there are also problems that may cause apprehension among clinicians and researchers. Hence, many challenges still remain for these multiplexing systems which are at early stages of development.

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Singlet oxygen species and systemic lupus erythematosus: a brief review

Cited by 24 publications

References 33 publications

Altered redox regulation by Nrf2-Keap1 system in dendritic cells of systemic lupus erythematosus patients

Altered redox regulation by Nrf2-Keap1 system in dendritic cells of systemic lupus erythematosus patients

Crosstalk between oxidative stress and ocular diseases

Multiplex Technology for Biomarker Immunoassays

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