We investigate the processes of laser radiation transformation by biological crystal networks using the singular optics techniques. The obtained results show a distinct correlation between the points of "characteristic" values of coordinate distributions of Mueller matrix (M(ik) = 0, ± 1) elements and polarization singularities (L- and C-points) in laser images of biological crystal networks with the following possibility of Mueller-matrix selection of polarization singularity. The technique of Mueller-matrix singular diagnostics of pathological changes in a woman's reproductive sphere tissue (myometrium) is proposed.