This article proposes a family of spatial three translational and one rotational parallel mechanisms (PMs) for pick-andplace operation. Their features are one independent rotation of the mechanism with four identical limbs, which are provided by the four revolute joints on the moving platform. The rotational capability of the PMs has a range of at least 180°. This article focuses on the synthesis of the PMs and kinematics analysis of the 4-P(2-SS)R parallel mechanism. First, based on the Lie group theory, three parallelograms are used in designing the PMs. The limbs are listed and two types of three translational and one rotational PMs are synthesized. Then, a typical 4-P(2-SS)R PM is selected, the 6 3 6 Jacobian matrix and the 6 3 6 3 6 Hessian matrix of the mechanism are derived for solving the displacement, velocity, and acceleration of the mechanism. Finally, singularity configurations are disclosed from the 6 3 6 Jacobian matrix, and the workspace of the mechanism is provided to illustrate the high rotational capability.