Sinigrin Attenuates the Dextran Sulfate Sodium-induced Colitis in Mice by Modulating the MAPK Pathway

Kotipalli, Rama Satya Sri; Tirunavalli, Satya Krishna; Pote, Aniket Balasaheb; Sahu, Bidya Dhar; Kuncha, Madhusudhana; Jerald, Mahesh Kumar; Sistla, Ramakrishna; Andugulapati, Sai Balaji

doi:10.1007/s10753-022-01780-4

Cited by 10 publications

(4 citation statements)

References 56 publications

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“…The most recent studies are summarized in Table 3 . These activities have been evidently linked to the classically known anti-inflammatory phytochemicals such as polyphenols, but also to other phytonutrients of BP such as lipids, peptides, polysaccharides, and other compounds [ 11 , 171 , 181 , 196 , 197 ]. In addition to the obvious differences according to the botanical origin of BP, differences in anti-inflammatory activity were reported according to bee species.…”

Section: Resultsmentioning

confidence: 99%

“…Many other nutrients which are known to be present in BP, such as vitamins (e.g., A, B group, C, D, E, and K [ 209 , 210 ]) and unsaturated fatty acids [ 211 ], are also widely known for their anti-inflammatory effects. In addition to all of those compounds, tannins [ 171 ] and glucosinolates [ 197 ] have also been shown to exert important anti-inflammatory activities through diverse mechanisms.…”

Section: Resultsmentioning

confidence: 99%

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Translational Research on Bee Pollen as a Source of Nutrients: A Scoping Review from Bench to Real World

Kacemi,

Campos

2023

Nutrients

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The emphasis on healthy nutrition is gaining a forefront place in current biomedical sciences. Nutritional deficiencies and imbalances have been widely demonstrated to be involved in the genesis and development of many world-scale public health burdens, such as metabolic and cardiovascular diseases. In recent years, bee pollen is emerging as a scientifically validated candidate, which can help diminish conditions through nutritional interventions. This matrix is being extensively studied, and has proven to be a very rich and well-balanced nutrient pool. In this work, we reviewed the available evidence on the interest in bee pollen as a nutrient source. We mainly focused on bee pollen richness in nutrients and its possible roles in the main pathophysiological processes that are directly linked to nutritional imbalances. This scoping review analyzed scientific works published in the last four years, focusing on the clearest inferences and perspectives to translate cumulated experimental and preclinical evidence into clinically relevant insights. The promising uses of bee pollen for malnutrition, digestive health, metabolic disorders, and other bioactivities which could be helpful to readjust homeostasis (as it is also true in the case of anti-inflammatory or anti-oxidant needs), as well as the benefits on cardiovascular diseases, were identified. The current knowledge gaps were identified, along with the practical challenges that hinder the establishment and fructification of these uses. A complete data collection made with a major range of botanical species allows more robust clinical information.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Translational Research on Bee Pollen as a Source of Nutrients: A Scoping Review from Bench to Real World

Kacemi,

Campos

2023

Nutrients

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“…Regarding the upstream mechanism, protein expression analysis based on western blot was investigated further. As aforementioned, MAPK signaling pathway is involved in the regulation of environmental factors on DSS-induced colitis in mice [ 35 , 36 ]. PS-NPs exacerbate lipopolysaccharide-induced inflammation and necrosis in the mouse spleen via the ROS/MAPK signaling pathway [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

Polystyrene nanobeads exacerbate chronic colitis in mice involving in oxidative stress and hepatic lipid metabolism

Ma,

Wan,

Song

et al. 2023

Part Fibre Toxicol

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Background Nanoplastics (NPs) are omnipresent in our lives as a new type of pollution with a tiny size. It can enter organisms from the environment, accumulate in the body, and be passed down the food chain. Inflammatory bowel disease (IBD) is a nonspecific intestinal inflammatory disease that is recurrent and prevalent in the population. Given that the intestinal features of colitis may affect the behavior and toxicity of NPs, it is imperative to clarify the risk and toxicity mechanisms of NPs in colitis models. Methods and results In this study, mice were subjected to three cycles of 5-day dextran sulfate sodium (DSS) exposures, with a break of 7 to 11 days between each cycle. After the first cycle of DSS exposure, the mice were fed gavagely with water containing 100 nm polystyrene nanobeads (PS-NPs, at concentrations of 1 mg/kg·BW, 5 mg/kg·BW and 25 mg/kg·BW, respectively) for 28 consecutive days. The results demonstrated that cyclic administration of DSS induced chronic inflammation in mice, while the standard drug “5-aminosalicylic acid (5-ASA)” treatment partially improved colitis manifestations. PS-NPs exacerbated intestinal inflammation in mice with chronic colitis by activating the MAPK signaling pathway. Furthermore, PS-NPs aggravated inflammation, oxidative stress, as well as hepatic lipid metabolism disturbance in the liver of mice with chronic colitis. Conclusion PS-NPs exacerbate intestinal inflammation and injury in mice with chronic colitis. This finding highlights chronically ill populations’ susceptibility to environmental hazards, which urgent more research and risk assessment studies.

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“…[3,5] Edema and ulcers are the most common symptoms of colonic mucosal inflammation. [6] Additionally, severe acute symptoms can raise the possibility of late intestinal symptoms, which can lead to the development of chronic colitis symptoms. [7] Further, 5-20% of patients will persist or develop symptoms for months to years after radiotherapy, which may become permanently.…”

Section: Introductionmentioning

confidence: 99%

Naringenin Alleviates Radiation‐Induced Intestinal Injury by Inhibiting TRPV6 in Mice

Ling,

Wang,

Chen

et al. 2024

Molecular Nutrition Food Res

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ScopeNaringenin (NAR) possesses unique anti‐inflammatory, antiapoptosis effects and various bioactivities; however, its role against radiation‐induced intestinal injury (RIII) remains unclear. This study aims to investigate whether NAR has protective effects against radiation‐induced intestinal injury and the underlying mechanisms.Methods and resultsC57BL/6J mice are exposed to a single dose of 13 Gy X‐ray total abdominal irradiation (TAI), then gavaged with NAR for 7 days. NAR treatment prolongs the survival rate, protects crypts and villi from damage, alleviates the level of radiation‐induced inflammation, and mitigates intestinal barrier damage in the irradiated mice. Additionally, NAR reduces immune cell infiltration and intestinal epithelial cell apoptosis. NAR also shows radioprotective effects in human colon cancer cells (HCT116) and human intestinal epithelial cells (NCM460). It reduces cell damage by reducing intracellular calcium ion levels and reactive oxygen species (ROS) levels. NAR‐mediated radioprotection is associated with the downregulation of transient receptor potential vanilloid 6 (TRPV6), and inhibition of apoptosis pathway. Notably, treatment with NAR fails to further increase the protective effects of the TRPV6 inhibitor 2‐APB, indicating that TRPV6 inhibition is essential for NAR activity.ConclusionNAR inhibits the apoptosis pathway by downregulating TRPV6 and reducing calcium ion level, thereby alleviating RIII. Therefore, NAR is a promising therapeutic drug for RIII.

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Sinigrin Attenuates the Dextran Sulfate Sodium-induced Colitis in Mice by Modulating the MAPK Pathway

Cited by 10 publications

References 56 publications

Translational Research on Bee Pollen as a Source of Nutrients: A Scoping Review from Bench to Real World

Translational Research on Bee Pollen as a Source of Nutrients: A Scoping Review from Bench to Real World

Polystyrene nanobeads exacerbate chronic colitis in mice involving in oxidative stress and hepatic lipid metabolism

Naringenin Alleviates Radiation‐Induced Intestinal Injury by Inhibiting TRPV6 in Mice

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