Sinisan alleviates depression-like behaviors by regulating mitochondrial function and synaptic plasticity in maternal separation rats

Deng, Di; Cui, Yongfei; Gan, Shu; Xie, Zedan; Cui, Sainan; Cao, Kerun; Wang, Shanshan; Shi, Guoqi; Yang, Lei; Bai, Shasha; Shi, Yafei; Liu, Zhongqiu; Zhao, Jinlan; Zhang, Rong

doi:10.1016/j.phymed.2022.154395

Cited by 40 publications

(18 citation statements)

References 53 publications

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“…PSD-95 is an important postsynaptic density protein. It plays key regulatory roles in the transmission of information between synapses, synaptic plasticity, the formation of synapses and the development of excitatory synapses [ 40 , 41 ]. A decrease in the expression level of PSD-95 directly reflects synaptic plasticity and the normal function of synapses.…”

Section: Discussionmentioning

confidence: 99%

Effects of Cyfluthrin Exposure on Neurobehaviour, Hippocampal Tissue and Synaptic Plasticity in Wistar Rats

Xie,

Zhao,

et al. 2023

Toxics

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This experiment was conducted to study the effects of Cyfluthrin (Cy) exposure on neurobehaviour, hippocampal tissue and synaptic plasticity in Wistar rats. First, it was found that high-dose Cy exposure could cause nerve injury, resulting in symptoms such as deficits in learning and memory ability, spatial exploration and autonomic motor function. Moreover, it was found that medium- and high-dose Cy exposure could cause an abnormal release of the neurotransmitter Glu. Second, brain tissue pathology showed that the middle and high doses of Cy caused tissue deformation, reduced the number of hippocampal puramidal cells, caused a disorder of these cells, decreased the number of Nissl bodies, and caused pyknosis of the hippocampal cell nuclear membrane and serious damage to organelles, indicating that exposure to these doses of Cy may cause hippocampal tissue damage in rats. Third, as the exposure dose increased, morphological changes in hippocampal synapses, including blurred synaptic spaces, a decreased number of synaptic vesicles and a decreased number of synapses, became more obvious. Moreover, the expression levels of the key synaptic proteins PSD-95 and SYP also decreased in a dose-dependent manner, indicating obvious synaptic damage. Finally, the study found that medium and high doses of Cy could upregulate the expression of A2AR in the hippocampus and that the expression levels of inflammatory factors and apoptosis-related proteins increased in a dose-dependent manner. Moreover, the expression of A2AR mRNA was correlated with neurobehavioural indicators and the levels of inflammatory factors, synaptic plasticity-related factors and apoptosis-related factors, suggesting that Cy may cause nerve damage in rats and that this effect is closely related to A2AR.

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Section: Discussionmentioning

confidence: 99%

Effects of Cyfluthrin Exposure on Neurobehaviour, Hippocampal Tissue and Synaptic Plasticity in Wistar Rats

Xie,

Zhao,

et al. 2023

Toxics

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“…These behavioral features may be consequences of poor maternal behavior. It is widely accepted that maternal separation during first 2–3 weeks of life leads to anxiety and depression-like behavior, as well as worsening motivation in young animals [ 37 , 38 ]. Only Wistar males and OXYS females were found to distinguish the novel from familiar object, and only Wistar females recognized the object in the RR test.…”

Section: Discussionmentioning

confidence: 99%

Delayed Formation of Neonatal Reflexes and of Locomotor Skills Is Associated with Poor Maternal Behavior in OXYS Rats Prone to Alzheimer’s Disease-like Pathology

et al. 2022

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Postnatal brain development is characterized by high plasticity with critical windows of opportunity where any intervention may positively or adversely influence postnatal growth and lead to long-lasting consequences later in life. Poor maternal care is among these interventions. Here, we found that senescence-accelerated OXYS rats prone to an Alzheimer’s disease-like pathology are characterized by more passive maternal behavior and insufficient care for pups as compared to control (Wistar) rats. OXYS pups demonstrated a delay in physical development (of auricle detachment, of emergence of pelage and incisors, of eye opening, and of vaginal opening in females) and late manifestation of reflexes and locomotor skills. All observed behavioral abnormalities are connected either with poor coordination of limbs’ movements or with a decrease in motivation and development of depression-like behavior. It is possible that their manifestations can be promoted by the features of maternal behavior of OXYS rats. Overall, these early-life events may have long-lasting consequences and contribute to neurodegeneration and development of the Alzheimer’s disease-like pathology later in life.

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“…level is significantly increased in hippocampus of depressive mice induced by CUMS. Moreover, Deng et al 71 have also shown that both Drp1 and Fis1 levels are increased in the hippocampus of depressive rats induced by maternal separation, while the antidepressant administration can reverse the abnormal expression of Drp1 and Fis1.…”

Section: Mitochondrial Fusion and Fissionmentioning

confidence: 98%

Mitochondria in depression: The dysfunction of mitochondrial energy metabolism and quality control systems

Jiang,

Wang,

Sheng

2024

CNS Neurosci Ther

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BackgroundDepression is the most disabling neuropsychiatric disorder, causing difficulties in daily life activities and social interactions. The exact mechanisms of depression remain largely unclear. However, some studies have shown that mitochondrial dysfunction would play a crucial role in the occurrence and development of depression.AimsTo summarize the known knowledge about the role of mitochondrial dysfunction in the pathogenesis of depression.MethodsWe review the recent literature， including 105 articles, to summarize the mitochondrial energy metabolism and quality control systems in the occurrence and development of depression. Some antidepressants which may exert their effects by improving mitochondrial function are also discussed.ResultsImpaired brain energy metabolism and (or) damaged mitochondrial quality control systems have been reported not only in depression patients but in animal models of depression. Although the classical antidepressants have not been specially designed to target mitochondria, the evidence suggests that many antidepressants may exert their effects by improving mitochondrial function.ConclusionsThis brief review focuses on the findings that implicate mitochondrial dysfunction and the quality control systems as important etiological factors in the context of depressive disorders. It will help us to understand the various concepts of mitochondrial dysfunction in the pathogenesis of depression, and to explore novel and more targeted therapeutic approaches for depression.

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Sinisan alleviates depression-like behaviors by regulating mitochondrial function and synaptic plasticity in maternal separation rats

Cited by 40 publications

References 53 publications

Effects of Cyfluthrin Exposure on Neurobehaviour, Hippocampal Tissue and Synaptic Plasticity in Wistar Rats

Effects of Cyfluthrin Exposure on Neurobehaviour, Hippocampal Tissue and Synaptic Plasticity in Wistar Rats

Delayed Formation of Neonatal Reflexes and of Locomotor Skills Is Associated with Poor Maternal Behavior in OXYS Rats Prone to Alzheimer’s Disease-like Pathology

Mitochondria in depression: The dysfunction of mitochondrial energy metabolism and quality control systems

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