Sink Group Betweenness Centrality

Fragkou, Evangelia; Katsaros, Dimitrios; Manolopoulos, Yannis

doi:10.1145/3472163.3472182

Cited by 1 publication

(1 citation statement)

References 38 publications

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“…Graph theory analysis methods have been widely used to analyze the structural and functional networks of brain magnetic resonance images (Bullmore and Sporns, 2009;Zhang and Luo, 2017;Ray et al, 2018). This method reflects some properties of the whole-brain network by quantifying the topological properties of each sub-network of the whole-brain (Fragkou et al, 2021). In graph theory, BC is one of the measures of the centrality of network graphs based on shortest paths.…”

Section: Discussionmentioning

confidence: 99%

Treatment Enhances Betweenness Centrality of Fronto-Parietal Network in Parkinson’s Patients

Liu

Shi

Wang

et al. 2022

Front. Comput. Neurosci.

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Previous studies have demonstrated a close relationship between early Parkinson’s disease and functional network abnormalities. However, the pattern of brain changes in the early stages of Parkinson’s disease has not been confirmed, which has important implications for the study of clinical indicators of Parkinson’s disease. Therefore, we investigated the functional connectivity before and after treatment in patients with early Parkinson’s disease, and further investigated the relationship between some topological properties and clinicopathological indicators. We included resting state-fMRI (rs-fMRI) data from 27 patients with early Parkinson’s disease aged 50–75 years from the Parkinson’s Disease Progression Markers Initiative (PPMI). The results showed that the functional connectivity of 6 networks, cerebellum network (CBN), cingulo_opercular network (CON), default network (DMN), fronto-parietal network (FPN), occipital network (OCC), and sensorimotor network (SMN), was significantly changed. Compared to before treatment, the main functional connections were concentrated in the CBN after treatment. In addition, the coefficients of these nodes have also changed. For betweenness centrality (BC), the FPN showed a significant improvement in treatment (p < 0.001). In conclusion, the alteration of functional networks in early Parkinson’s patients is critical for clarifying the mechanisms of early diagnosis of the disease.

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