Sinonasal cancer: an overview of the emerging subtypes

Virk, Jagdeep Singh; Chan, John; Dimitrov, L; Williamson, Andrew; Sandison, Ann; Weir, Justin; Clarke, Peter

doi:10.1017/s0022215120000146

Cited by 13 publications

(8 citation statements)

References 29 publications

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“…Primary paranasal sinus cancers are rare, comprising only about 2% to 3% of head and neck cancer, with squamous cell carcinoma being the most common histologic diagnosis 11 . Malignancies of the sinuses exhibit a considerable level of heterogeneity in terms of etiology and outcomes, and there are several identifiable risk factors, including age, tobacco use, sex, and human papillomavirus, in addition to race 12,13 . Management generally includes surgical resection and adjuvant therapy.…”

Section: Introductionmentioning

confidence: 99%

“…11 Malignancies of the sinuses exhibit a considerable level of heterogeneity in terms of etiology and outcomes, and there are several identifiable risk factors, including age, tobacco use, sex, and human papillomavirus, in addition to race. 12,13 Management generally includes surgical resection and adjuvant therapy. The mortality rate for paranasal sinus cancer is high, particularly for patients who present at late stages.…”

Section: Introductionmentioning

confidence: 99%

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Racial and ethnic disparities in paranasal sinus malignancies

Sharma

Schlosser

Beswick

et al. 2021

Int Forum Allergy Rhinol

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Background: Racial and ethnic disparities in cancer outcomes have been demonstrated for several different malignancies. In this study we aimed to quantify disease-specific survival (DSS) and the 5-year conditional disease-specific survival (CDSS, the change in life expectancy with increasing survivorship) for paranasal sinus cancer by race and ethnicity. Methods: Patients with sinus cancer between 1973 and 2015 were extracted from the Surveillance, Epidemiology, End Results (SEER) registry. Kaplan-Meier analysis for DSS was stratified by race and ethnicity. Cox regression models of DSS were generated controlling for stage, age, race, and ethnicity. CDSS was calculated using Cox models. Logistic regression was conducted to identify risk factors for younger age at diagnosis, late-stage at diagnosis, and likelihood of receiving surgical intervention when recommended. Results:The analysis included a total of 5202 patients. DSS was significantly different when stratified by race (p < 0.01). Compared with White patients, Black patients (hazard ratio [HR], 1.29; 95% confidence interval [CI], 1.13-1.45; p < 0.001) and American Indian/Alaskan Natives (HR, 1.94; 95% CI, 1.37-2.74, p < 0.001) exhibited increased mortality when controlling for other factors.Black patients had worse CDSS for regional and distant staged cancer compared with other races; American Indian/Alaskan Native patients had worse CDSS for cancers of all stages. Hispanic patients were more likely to present with advanced disease (odds ratio [OR], 1.47; 95% CI, 1.07-2.07; p = 0.020). American Indian/Alaskan Native patients were less likely than White patients to receive surgical intervention when recommended (OR, 0.42; 95% CI, 0.21-0.04; p = 0.024). Nonwhite patients were more likely to be diagnosed at a younger age.Variations in racial and ethnic disparities were observed over time. Conclusion: Race and ethnicity significantly impact paranasal sinus cancer outcome metrics. Disparities in outcomes are likely multifactorial.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Racial and ethnic disparities in paranasal sinus malignancies

Sharma

Schlosser

Beswick

et al. 2021

Int Forum Allergy Rhinol

View full text Add to dashboard Cite

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“…During this time span, literature has progressively shifted its focus from analyzing outcomes of different surgical approaches to explore which multimodal treatment protocol could offer the best oncologic outcome, driven by histological subtypes. The implementation of such histology-driven strategies in multidisciplinary settings have allowed to achieve better survival outcomes [1][2][3][4]. Therefore, the survivors' population progressively expanded, so as did recurrences, the management of which has now become a critical issue.…”

Section: Introductionmentioning

confidence: 99%

Patterns of recurrences in sinonasal cancers undergoing an endoscopic surgery-based treatment: Results of the MUSES* on 940 patients

Arosio¹,

Bernasconi²,

Valsecchi³

et al. 2022

Oral Oncology

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“…1 Squamous cell carcinoma and adenocarcinoma account for most primary sinus and nasal cavity cancers, although there is considerable variety in etiological, pathological, and genetic features of these tumors. 2 The maxillary sinus is most commonly involved site among paranasal sinus tumors, and risk factors commonly include age, race and tobacco use. 3 Comprehensive management generally involves surgical resection in addition to adjuvant treatment, which may include both radiation therapy and chemotherapy.…”

Section: Introductionmentioning

confidence: 99%

Conditional and Overall Disease-Specific Survival in Patients With Paranasal Sinus and Nasal Cavity Cancer: Improved Outcomes in the Endoscopic Era

Sharma

Irace

Schlosser

et al. 2021

Am J Rhinol�Allergy

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Background The management of paranasal sinus and nasal cavity malignancies has evolved significantly with the development of advanced endoscopic techniques and improvements in adjuvant therapy. We sought to characterize both disease-specific survival (DSS) and 5-year conditional disease-specific survival (CDSS, the change in life expectancy with increasing survivorship) for sinus malignancies diagnosed before and after the year 2000. Methods Patients diagnosed with sinus and nasal cavity cancer between 1973-2015 were extracted from the Surveillance, Epidemiology, End Results (SEER) registry. Kaplan-Meier analysis for DSS was stratified by year of diagnosis before and after 2000. Cox-proportional hazards models of DSS controlling for stage, age, and year of diagnosis were generated. CDSS was calculated using Cox-regression models stratified by stage. Results We analyzed 10,535 patients. Diagnosis after the year 2000 was independently associated with improved DSS (HR:0.81, 95% CI: 0.75-0.87, P < .001) after controlling for age and stage. After stratifying by stage, diagnosis after year 2000 was associated with improved DSS for localized (HR:0.71, 0.59-0.86, P < .001) malignancies, regional (HR: 0.86, 0.78-0.94, P = .001) and distant malignancies (HR 0.74, 0.63-0.87, P < .001). CDSS improved with increasing survivorship for all stages of sinus and nasal cavity cancer, and those diagnosed after 2000 had improved CDSS compared to those diagnosed before 2000. Descriptively, the association of year of diagnosis with CDSS diminished with increasing survivorship for localized cancers, but was consistent for other stages. Conclusion For paranasal sinus and nasal cavity malignancies, year of diagnosis independently influences both DSS and CDSS. Improved survival is likely due to advances in both surgical and adjuvant treatments. To our knowledge, this study is the first to examine CDSS for these malignancies.

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Sinonasal cancer: an overview of the emerging subtypes

Cited by 13 publications

References 29 publications

Racial and ethnic disparities in paranasal sinus malignancies

Racial and ethnic disparities in paranasal sinus malignancies

Patterns of recurrences in sinonasal cancers undergoing an endoscopic surgery-based treatment: Results of the MUSES* on 940 patients

Conditional and Overall Disease-Specific Survival in Patients With Paranasal Sinus and Nasal Cavity Cancer: Improved Outcomes in the Endoscopic Era

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