Sinonasal cancer in The Netherlands: Follow‐up of a population‐based study 1989‐2014 and incidence of occupation‐related adenocarcinoma

Abstract

Background Long‐term trends of sinonasal cancer in The Netherlands have been investigated with particular attention on adenocarcinoma for which wood or leather dust is a well‐known risk factor. Methods All 4345 patients (1989‐2014) registered in the Netherlands Cancer Registry were included. Standardized 3‐year moving incidence rates per 1 000 000/person‐years, and estimated annual percentage change (EAPC) were calculated. Results Forty‐seven percent of the patients had squamous cell carcinoma (SCC), 12% had lymphoma, and 12% had adenocarcinoma. Sixty‐one percent of the tumors were located in the nasal cavity, 22% in the maxillary, and 11% in the ethmoidal sinus. Male incidence decreased to 11.5/1 000 000 due to less SCC (EAPC −0.9%; 95% confidence interval [CI] −1.6 to 0.3) and adenocarcinoma (EAPC −4.3%; 95% CI −5.5 to 3.1). Female incidence increased to 7/1 000 000 (EAPC +2.0%; 95% CI +1.1 to +3.0) due to more SCC (EAPC +2.2%; 95% CI +1.0 to +3.5), whereas adenocarcinoma remained stable (0.6/1 000 000; EAPC +1.1%; 95% CI −6.0 to +8.7). Tumors of the nasal cavity increased in women (EAPC +3.3%; 95% CI +2.0 to 4.7). Conclusion The decrease of male sinonasal adenocarcinoma may be the result of preventive measures combined with less workers in high‐risk occupations.

Sinonasal adenocarcinoma: a case series

“…Sinonasal cancer is uncommon in most populations (1.5 per 100,000 males and 1.0 per 100,000 women), with higher prevalence in Japan and certain sections of China and India (2) . Patients with sinonasal adenocarcinoma are on average around 60 years old, with the highest prevalence in males (70%).…”

“…inonasal cancer accounts for approximately 1% of all cancers and about 3% of head and neck cancers (1) . Squamous cell carcinomas are the most common sinonasal cancers (50-75%) followed by adenocarcinomas (2) . The two histological subtypes of sinonasal adenocarcinomas are salivary-type and non-salivary-type.…”

Novel Biomarkers in Sinonasal Cancers: from Bench to Bedside

“…Importantly, ITACs are associated with long-term occupational exposure to hard wood dust, which is thought to drive carcinogenesis. In addition, leather dust exposure has also been demonstrated to be an important risk factor [58][59][60][61]. Treatment recommendations involve complete surgical resection, when possible, using either the open or the endoscopic approach.…”

Survival of Patients with Sinonasal Cancers in a Population-Based Registry, Lombardy, Italy, 2008–2023

“…Sinonasal cancers (SNCs) are rare malignancies (<1% of all cancers) of the nasal cavity or paranasal sinuses (maxillary, ethmoidal, frontal, and sphenoidal) [ 1 , 2 ]. The SNC incidence rate is below 1–2 per 100,000 person-years and more frequent (roughly double) in men [ 3 , 4 , 5 , 6 , 7 ]. The most frequently affected anatomical sites are the nasal cavity and the maxillary and ethmoidal sinuses [ 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 ].…”

“…The SNC incidence rate is below 1–2 per 100,000 person-years and more frequent (roughly double) in men [ 3 , 4 , 5 , 6 , 7 ]. The most frequently affected anatomical sites are the nasal cavity and the maxillary and ethmoidal sinuses [ 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 ]. The majority of SNCs (80%) are epithelial; the most frequent morphologies are squamous cell carcinoma (SCC), mostly in the maxillary sinus and nasal cavity, and intestinal-type adenocarcinoma (ITAC), which often arises in the ethmoidal sinus [ 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 ].…”