Sinonasal Characteristics in Patients with Obstructive Sleep Apnea Compared to Healthy Controls

Moxness, Mads Henrik Strand; Bugten, Vegard; Thorstensen, Wenche Moe; Nordgård, Ståle

doi:10.1155/2017/1935284

Cited by 11 publications

(8 citation statements)

References 21 publications

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“…It is likely that the included patients are representative of patients with nonsevere OSA, who do not need nasal or pharyngeal surgical corrections, and are referred to Norwegian public and private hospitals. The patients had higher BMI and worse self-reported general health than the Norwegian general population at baseline [ 42 , 43 ], but were comparable to OSA populations in other recent Norwegian studies [ 2 , 44 ]. The mean values for all SF36 domains at baseline were lower than but within one standard deviation from the mean values of the Norwegian general population [ 45 ].…”

Section: Discussionmentioning

confidence: 66%

Health-Related Quality of Life and Sleep Quality after 12 Months of Treatment in Nonsevere Obstructive Sleep Apnea: A Randomized Clinical Trial with Continuous Positive Airway Pressure and Mandibular Advancement Splints

Berg

Ankjell

Sun

et al. 2020

International Journal of Otolaryngology

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In this randomized controlled trial, patients with nonsevere obstructive sleep apnea (OSA) were treated with continuous positive airway pressure (CPAP) or a twin block mandibular advancement splint (MAS). The primary objective was to compare how CPAP and MAS treatments change the health-related quality of life (HRQoL) and self-reported sleep quality of patients after 12 months of treatment. In total, 104 patients were recruited: 55 were allocated to the CPAP treatment group and 49 to the MAS treatment group. We used the SF36 questionnaire to evaluate HRQoL and the Pittsburgh Sleep Quality Index (PSQI) to evaluate sleep quality. All patients were included in the intention-to-treat analyses. These analyses showed improvements in the SF36 physical component score (from 48.8 ± 7.6 at baseline to 50.5 ± 8.0 at follow-up, p=0.03) in the CPAP treatment group and in the mental component score (from 44.9 ± 12.1 to 49.3 ± 9.2, p=0.009) in the MAS treatment group. The PSQI global score improved in both the CPAP (from 7.7 ± 3.5 to 6.6 ± 2.9, p=0.006) and the MAS (8.0 ± 3.1 to 6.1 ± 2.6, p<0.001) treatment groups. No difference was found between the treatment groups in any of the SF36 scores or PSQI global score at the final follow-up (p>0.05) in any analysis. The improvement in the SF36 vitality domain moderately correlated to the improvement in the PSQI global score in both groups (CPAP: r=0.47, p<0.001; MAS: r=0.36, p=0.01). In the MAS treatment group, we also found a weak correlation between improvements in the SF36 mental component score and PSQI global score (r=0.28, p=0.05). In conclusion, CPAP and MAS treatments lead to similar improvements in the HRQoL and self-reported sleep quality in nonsevere OSA. Improvements in aspects of HRQoL seem to be moderately correlated to the self-reported sleep quality in both CPAP and MAS treatments.

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Section: Discussionmentioning

confidence: 66%

Health-Related Quality of Life and Sleep Quality after 12 Months of Treatment in Nonsevere Obstructive Sleep Apnea: A Randomized Clinical Trial with Continuous Positive Airway Pressure and Mandibular Advancement Splints

Berg

Ankjell

Sun

et al. 2020

International Journal of Otolaryngology

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“…We compared the results from our patients that reported headache scores between 17 and 25 on the VAS postoperatively with headache scores documented by healthy controls in other studies. We found that healthy people present an average headache score between 16 and 20 on the VAS [32,33], indicating that our patients reached after surgery the same headache level as healthy people.…”

Section: Discussionsupporting

confidence: 59%

Sinus or nasal surgery alleviates headache symptoms: A prospective study

Bugten¹

2018

Arch Otolaryngol Rhinold

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Introduction: The primary aim of this prospective study was to evaluate headache severity before and after surgery in patients with chronic rhinosinusitis without polyps (CRSsNP), chronic rhinosinusitis with polyps (CRSwNP), deviated nasal septum (DNS), and inferior turbinate hypertrophy (ITH). Our secondary aim was to compare the improvement of headache symptoms in these different patient groups. Methods: We enrolled 154 patients with CRSsNP, 130 patients with CRSwNP, 144 patients with DNS with or without ITH, and 69 patients with only ITH. Problems with headaches were reported on a visual analogue scale (VAS) preoperatively and six months postoperatively. Results: Patients with CRSsNP reported preoperatively signifi cantly more headaches on the VAS than the other patient groups. Headaches improved signifi cantly after surgery (p<0.001) but they improved more in CRSsNP patients than in other patient groups. Postoperatively, there were no signifi cant differences in headache problems between the groups. The CRSsNP group reported 50 (standard deviation [SD] 29) on the VAS preoperatively and 25 (SD 26) postoperatively, the CRSwNP group reported 28 (SD 30) versus 18 (SD 25), the DNS group reported 31 (SD 30) versus 17 (SD 24), and the ITH group reported 31 (SD 32) versus 19 (SD 25). Subgroup analyses identifi ed gender as a factor that has an infl uence on the headache. Female patients reported a mean VAS score of 49 (SD 31) preoperatively and 28 (SD 28) postoperatively. Male patients reported a mean VAS score of 29 (SD 29) preoperatively and 15 (SD 22) postoperatively. Conclusion: In this study, we have shown that patients with CRSsNP report more headache-related problems preoperatively than patients diagnosed with CRSwNP, DNS, or ITH. All patient groups exhibit a signifi cant improvement in their headache problems and report milder symptoms postoperatively. Female patients tend to report more headaches than men.

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“…Repetitive obstructive episodes cause ischemia‐reperfusion injury to the airway, all the while OSA patients have increased systemic inflammatory mediators predisposing the soft tissues to free‐radical development . These same theories have been proposed recently for two small cohort samples finding higher levels of sinonasal complaints in OSA patients, though no study has definitively linked OSA and higher rates of sinusitis. It is worth mentioning that a separate study of our cohort found no difference in sinusitis QOL scores (by Sino‐Nasal Outcome Test) between OSA and non‐OSA patients.…”

Section: Discussionmentioning

confidence: 88%

Are chronic cough and laryngopharyngeal reflux more common in obstructive sleep apnea patients?

et al. 2018

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Objectives/Hypothesis To assess if there is a significant difference in the prevalence and severity of chronic cough symptoms in obstructive sleep apnea (OSA) patients versus non‐OSA patients and examine this relationship in regard to laryngopharyngeal reflux (LPR) symptoms. Study Design Prospective cohort study. Methods Patients referred to Northwestern Medicine Sleep Lab for home sleep testing were enrolled. Patients filled out the Leicester Cough Questionnaire (LCQ) and Reflux Symptom Index (RSI) before completing sleep testing. Home sleep testing results were reviewed, and patients were separated into non‐OSA and OSA groups by standard Apnea‐Hypopnea Index (AHI) criteria. Demographic characteristics and questionnaire scores of the two groups were compared. The relationship between OSA severity, as determined by AHI, and LCQ and RSI scores was assessed. Results Of the 52 patients enrolled, 33 patients met criteria for OSA and 19 patients did not. Comparing patients without OSA versus those with OSA, there was a significant difference in mean LCQ score (129.9 vs. 120.0, respectively; P = .02), implying worse cough symptoms among OSA patients, and mean RSI score (3.2 vs. 11.2, respectively; P = .0013), implying worse upper‐airway reflux symptoms among OSA patients. There was a significant correlation between LCQ score and AHI (r = –0.39, P = .0061) and between RSI score and AHI (r = 0.37, P = .0078). Conclusions OSA patients demonstrate worse chronic cough and LPR‐related quality of life versus non‐OSA patients. Furthermore, the severity of these quality‐of‐life measures was correlated with the severity of the AHI. Chronic cough and particularly the pharyngeal LPR symptoms may be associated with the presence and severity of OSA. Level of Evidence 2 . Laryngoscope, 129:1244–1249, 2019

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Sinonasal Characteristics in Patients with Obstructive Sleep Apnea Compared to Healthy Controls

Cited by 11 publications

References 21 publications

Health-Related Quality of Life and Sleep Quality after 12 Months of Treatment in Nonsevere Obstructive Sleep Apnea: A Randomized Clinical Trial with Continuous Positive Airway Pressure and Mandibular Advancement Splints

Health-Related Quality of Life and Sleep Quality after 12 Months of Treatment in Nonsevere Obstructive Sleep Apnea: A Randomized Clinical Trial with Continuous Positive Airway Pressure and Mandibular Advancement Splints

Sinus or nasal surgery alleviates headache symptoms: A prospective study

Are chronic cough and laryngopharyngeal reflux more common in obstructive sleep apnea patients?

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