Sinonasal Disease and Olfactory Impairment in HIV Disease: Endoscopic Sinus Surgery and Outcome Measures

Abstract

Objectives: To investigate the effects of ESS (ESS)on olfactory impairment, disease-specific symptoms, and general quality of well-being In HIV؉ patients with sinonasal disease. Study Design: Study 1: Nasal cytology, rhinomanometry, nasal examination including endoscopy, disease-specific sinonasal symptoms, olfactory threshold sensitivity, and odor identification testing were performed before and after ESS in HIV؉ patients with sinonasal complaints. Study 2: Quality of well-being was assessed before and after ESS in HIV؉ patients with sinonasal complaints and controls. Results: Significant olfactory sensitivity loss persisted for patients with chronic sinusitis after ESS, suggesting that the impairment in these patients may be due to viral disease rather than inflammation. Significant improvement in other disease-specific symptom scores (nasal obstruction, nasal congestion, headache, sinus pain, etc.) and results of the general quality of well-being assessment showed ESS to be beneficial in the extended health management of HIV illness. Conclusions: The current study indicated both olfactory dysfunction and subjective negative symptoms in HIV؉ patients with chronic sinusitis. Although olfactory dysfunction remained, ESS was successful in providing marked alleviation of symptomatology in HIV؉ patients with chronic sinusitis. The results support ESS as an appropriate treatment option for HIV؉ patients with chronic sinusitis.

Otorhinolaryngological Manifestations among HIV Positive Children in Coastal Karnataka

“…Oral candidiasis represents progressive disease with poor prognosis in children more than six months [14] and falls into stage III of disease [2]. The incidence of the disease again shows variation in numerous studies-90% in Nigeria [12], 60% in Thailand [10], and 20% in Romania [15]. Our study showed only a low incidence of 1.4%.…”

“…The manifestations reported in literature in the nose and paranasal sinuses in relation to HIV are recurrent rhinitis, sinusitis, nasal vestibulitis, epistaxis, hyposmia and hypoguesia [1,9,10]. Sinusitis, though not reported in many studies including ours, has a close association with the immunodeficiency of AIDS.…”

Rinossinusite crônica em pacientes infectados pelo vírus da imunodeficiência humana: avaliação clínica e radiológica

“…Prevalence of this disease in these individuals varied from 10% to 68%, as reported in the literature 1,2,4,5 .…”

“…Involvement of maxillary sinuses is common among HIV-infected population with rhinosinusitis 2,4,8,[14][15][16] . In our series, the most affected sinus in both groups was the maxillary sinus (100%).…”

“…The advent of protease inhibitors, which improves survival and quality of life of patients, has increased the number of asymptomatic HIV-infected individuals worldwide 1,2 . As a consequence, many of these patients have visited otorhinolaryngologists, since 40-70% of them may present some sort of otorhinolaryngological disorder 2,3 .…”