Sinonasal Ewing Sarcoma: A Case Report and Literature Review

Lin, Jonathan K.; Liang, Jonathan

doi:10.7812/tpp/17-086

Cited by 26 publications

(38 citation statements)

References 11 publications

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“…1 The essential diagnostic test to differentiate ES from the many small round neoplasms is the CD99 marker, which can be detected in a specific IHC examination. 1,3 Lesion…”

Section: Discussionmentioning

confidence: 99%

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Ewing’s sarcoma of sinonasal tract: a rare case

Sofia

Sen

2020

Int J Otorhinolaryngol Head Neck Surg

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<p class="abstract">Extra skeletal Ewing’s sarcoma (EES) is a rare, rapidly growing, round cell malignant tumour that can develop in the soft tissue at any location. Involvement of the paranasal sinus is a very rare entity. Nearly 80% of patients are younger than 20 years. Diagnosis is made after histopathological examination, immunohistochemical studies and cytogenetic studies. Treatment includes a multidisciplinary approach with surgery as the first line followed by chemotherapy and radiotherapy.</p><p class="abstract"> </p>

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“…1 The essential diagnostic test to differentiate ES from the many small round neoplasms is the CD99 marker, which can be detected in a specific IHC examination. 1,3 Lesion…”

Section: Discussionmentioning

confidence: 99%

“…This fusion results in a t (11,22) translocation which is found in 85 to 90% of the cases. 3,10 Clinical manifestations of sinonasal ES include enlarging mass, nasal obstruction, rhinorrhea, and epistaxis. 10 Approximately 18% of the patients are presented with metastasis at time of diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Ewing’s sarcoma of sinonasal tract: a rare case

Sofia

Sen

2020

Int J Otorhinolaryngol Head Neck Surg

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“…ES is a rare disease that accounts for only 4% to 6% of all primary bone tumors [2, 7, 8]. Furthermore, ES involves the head and neck region in only 1% to 4% of cases, and primary sinonasal ES is even rarer [2, 8].…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Ewing's sarcoma (ES) is a highly malignant and rare tumor that subdivided into skeletal and extraskeletal entities [1, 2]. The skeletal form is more common and typically involves the long bones of the extremities [1, 2]. The less common extraskeletal form involves soft tissues of the lower extremities, paravertebral tissues, chest wall, and retroperitoneum [1, 3].…”

Section: Introductionmentioning

confidence: 99%

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Pediatrics Ewing’s Sarcoma of the Sinonasal Tract: A Case Report and Literature Review

Aldandan

Almomen

Alkhatib

et al. 2019

Case Reports in Pathology

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Ewing's sarcoma (ES) is a highly malignant, small, round cell tumor that originates from the primitive neuroectodermal cells. Primary ES commonly occurs in early childhood or adolescence. It may present with skeletal and extraskeletal forms. The extraskeletal form is rarely encountered in the head and neck region and is extremely rare in the sinonasal tract. This is a case report of sinonasal ES in a 13-year-old female patient who presented with a 7-month history of right nasal obstruction, anosmia, intermittent epistaxis, snoring, and hearing loss. Clinical examination revealed a right nasal mass pushing the septum to the left side and extending to the nasopharynx. Endoscopic biopsy and histopathological analysis showed a small blue cell tumor suggestive of ES. The patient was treated with surgery, radiotherapy, and chemotherapy. After a follow-up of 5 years, the patient remains recurrence-free with excellent functional status and quality of life.

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Ewing Sarcoma of the Sinonasal Tract: A Scoping Review

Shaari,

Ho,

Patel

et al. 2024

The Laryngoscope

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ObjectiveEwing sarcoma (ES) is a rare aggressive malignancy that can present in the sinonasal region. The objective of this study is to investigate the demographics, presentation, management, and outcomes of patients with sinonasal ES.Data SourcesPubMed, Web of Science, SCOPUS, CINAHL, and Cochrane Library.Review MethodsA scoping review of cases of sinonasal ES was performed. Inclusion criteria consisted of case reports, series, or retrospective reviews.Results785 total articles were retrieved. 72 articles met inclusion criteria and were included in the final review for a total of 93 cases. 48 (53%) patients were male. Mean age at diagnosis was 26.4 years old (range 1–89). Nasal obstruction (N = 55, 59%), epistaxis (N = 35, 38%), and impaired vision (N = 29, 29%) were the most common symptoms. On examination, 38 (41%) patients had a nasal cavity mass. Most tumors (N = 33, 35%) were located in the maxillary sinus. 44 (47%) were left sided and 4 (4%) were bilateral. The most utilized treatment modalities were surgical resection with adjuvant chemoradiotherapy (N = 27, 29%), chemoradiotherapy alone (N = 24, 26%), and surgical resection with adjuvant chemotherapy (N = 14, 15%). 56 patients had no evidence of disease (60%), 14 patients died with disease (15%), and 9 patients were alive with disease (10%) at the time of follow‐up.ConclusionsTo our knowledge, we report the first scoping review of sinonasal ES. Patients generally present with non‐specific sinonasal symptoms. Surgery with adjuvant chemoradiation is the most common treatment modality for these patients.Level of EvidenceNA Laryngoscope, 2024

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Sinonasal Ewing Sarcoma: A Case Report and Literature Review

Cited by 26 publications

References 11 publications

Ewing’s sarcoma of sinonasal tract: a rare case

Ewing’s sarcoma of sinonasal tract: a rare case

Pediatrics Ewing’s Sarcoma of the Sinonasal Tract: A Case Report and Literature Review

Ewing Sarcoma of the Sinonasal Tract: A Scoping Review

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