Sinonasal extramedullary plasmacytoma: a population‐based incidence and survival analysis

Patel, Tapan D.; Vázquez, Alejandro; Choudhary, Manoj K.; Kam, David; Baredes, Soly; Eloy, Jean Anderson

doi:10.1002/alr.21544

Cited by 26 publications

(27 citation statements)

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“…This finding supports previously reported results, which suggested that SBP is frequently observed in marrow-containing bones, specifically vertebrae [19]. In addition, and in accordance with the findings reported by Patel et al, we found when analyzing our sample that the upper airway tract, including the sinuses, which have extensive lymphatic supply, was the most commonly involved EMP site [20]. …”

Section: Discussionsupporting

confidence: 93%

“…Our findings concur with this conclusion, with a male-to-female ratio of 1.6:1 [4, 20]. In existing studies focusing primarily on SBP, the male-to-female ratio was in the range of 1.5–2.4 [5, 6].…”

Section: Discussionsupporting

confidence: 91%

“…In existing studies focusing primarily on SBP, the male-to-female ratio was in the range of 1.5–2.4 [5, 6]. However, among EMP patients, a 3:1 male predominance was previously observed in sites involving upper airway tract [5, 20]. We also noted a gender bias in the survival rates, in which males achieved significantly better outcomes than females (64.1% vs 53.8%, p < 0.05).…”

Section: Discussionmentioning

confidence: 99%

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Solitary plasmacytoma: population-based analysis of survival trends and effect of various treatment modalities in the USA

et al. 2017

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BackgroundSolitary plasmacytoma (SP) is a localized neoplastic plasma cell disorder with an annual incidence of less than 450 cases. Given the rarity of this disorder, it is difficult to conduct large-scale population studies. Consequently, very limited information on the disorder is available, making it difficult to estimate the incidence and survival rates. Furthermore, limited information is available on the efficacy of various treatment modalities in relation to primary tumor sites.MethodsThe data for this retrospective study were drawn from the Surveillance, Epidemiology and End Results (SEER) database, which comprises 18 registries; patient demographics, treatment modalities and survival rates were obtained for those diagnosed with SP from 1998 to 2007. Various prognostic factors were analyzed via Kaplan-Meier analysis and log-rank test, with 5-year relative survival rate defined as the primary outcome of interest. Cox regression analysis was employed in the multivariate analysis.ResultsThe SEER search from 1998 to 2007 yielded records for 1691 SP patients. The median age at diagnosis was 63 years. The patient cohort was 62.4% male, 37.6% female, 80% Caucasian, 14.6% African American and 5.4% other races. Additionally, 57.8% had osseous plasmacytoma, and 31.9% had extraosseous involvement. Unspecified plasmacytoma was noted in 10.2% of patients. The most common treatment modalities were radiotherapy (RT) (48.8%), followed by combination surgery with RT (21.2%) and surgery alone (11.6%). Univariate analysis of prognostic factors revealed that the survival outcomes were better for younger male patients who received RT with surgery (p < 0.05). Additionally, patients who received neoadjuvant RT had increased survival rates compared to those receiving adjuvant RT (86% vs 73%, p < 0.05). Furthermore, the analyses revealed that 5-year survival rates for patients with axial plasmacytoma were superior when RT was combined with surgery (p < 0.05). In the multivariate analysis, age <60 years and treatment with either RT or surgery showed superior survival rates. Progression to multiple myeloma (MM) was noted in 551 patients. Age >60 years was associated with a lower 5-year survival in patients who progressed to MM compared to those who were diagnosed initially with MM (15.1 vs 16.6%). Finally, those who received RT and progressed to MM still had a higher chance of survival than those who were diagnosed with MM initially and treated with RT/surgery (21.8% vs 15.9%, p < 0.05).ConclusionsA review of the pertinent literature indicates that we provided the most comprehensive population-based analysis of SP to date. Moreover, our study contributes to the establishment of the optimal SP treatment modality, as RT is the favored option in frontline settings. Consensus is currently lacking regarding the benefits of combined treatment including surgery. Thus, the findings reported here elucidate the role of primary treatment modalities while also demonstrating the quantifiable benefits of combining RT with surgery in relation to...

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

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Solitary plasmacytoma: population-based analysis of survival trends and effect of various treatment modalities in the USA

et al. 2017

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“…[19][20][21][22][23][24][25][26][27][28][29][30][31][32][33] This dataset encompasses over 30 years of patient information. However, as with other large databases, the inability to access primary patient data may affect the analysis.…”

Section: Discussionmentioning

confidence: 99%

Sinonasal fibrosarcoma: analysis of the Surveillance, Epidemiology, and End Results database

Patel

Carniol

Vázquez

et al. 2015

Int Forum Allergy Rhinol

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“…(Table 4). Patel et al 58 identified 778 patients with EMP in the head and neck region, 137 of them reportedly have plasmacytoma in the nasopharynx. D'Aguillo et al 59 reported 176 cases of sinonasal extramedullary plasmacytoma, of which 36 cases were associated with the nasopharynx (Table 6).…”

mentioning

confidence: 99%

Outcomes of Patients With Nasopharyngeal Plasmacytoma: A Systematic Review

Ramadan¹

2017

Otolaryngol Open J

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Background: This study reviews the published literature related to nasopharyngeal plasmacytoma. Clinical presentation, demographics, treatment, and outcomes of this uncommon disease have been reported. Methods: A systematic review of studies on nasopharyngeal plasmacytoma from 1935 to 2016 was conducted. A PubMed database search was performed for articles related to this condition along with the bibliographies of those selected articles. Articles were examined for patient data that reported the disease outcome. Results: Fifty-eight journal articles were included in this analysis, comprising of a total of 114 studies indicative of a predilection for cases particularly in men with a mean age of 55 years (sixth decade of life) characterized with symptoms such as nasal obstruction, epistaxis and neck lymphadenopathy. Radiotherapy was the most common treatment modality, followed by a combination of surgery and radiotherapy. Most of the patients were alive with no evidence of the disease after the median follow-up of 59 months. Of the 3 most common treatment modalities, a combination of radiotherapy and surgery had the most favorable outcome for a majority of patients. The existing condition for 8 patients (7%) deteriorated leading to the development of multiple myeloma. Conclusion: This review contains a large pool of information about nasopharyngeal plasmacytoma patients examined to date suggesting that aggressive radiotherapy is the most common treatment modality for this condition. Of the 3 most common treatment modalities, a combination of surgery and radiotherapy was shown to have the best survival outcomes.

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Sinonasal extramedullary plasmacytoma: a population‐based incidence and survival analysis

Abstract: This study analyzed the largest cohort of SN-EMP patients to date. There was no statistically significant survival advantage found for any 1 particular treatment modality over other treatment modalities in both SN-EMP and other HN-EMP.

Cited by 26 publications

References 27 publications

Solitary plasmacytoma: population-based analysis of survival trends and effect of various treatment modalities in the USA

Solitary plasmacytoma: population-based analysis of survival trends and effect of various treatment modalities in the USA

Sinonasal fibrosarcoma: analysis of the Surveillance, Epidemiology, and End Results database

Outcomes of Patients With Nasopharyngeal Plasmacytoma: A Systematic Review

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