Sinonasal inverted papilloma: narrative review

Anari, Shahram; Carrie, Sean

doi:10.1017/s0022215110000599

Cited by 110 publications

(208 citation statements)

References 76 publications

(316 reference statements)

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“…Recurrence is more likely in fontal sinus papillomas, due to the technical difficulty of operating at this site [9]. Unlike ESP, there is a significant risk of progression to malignancy, usually squamous cell carcinoma, but occasionally verrucous or adenocarcinoma.…”

Section: Treatment and Prognosismentioning

confidence: 99%

Low-Grade Epithelial Proliferations of the Sinonasal Tract

Bullock

2016

Head and Neck Pathol

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Low-grade epithelial proliferations of the sinonasal tract include Schneiderian papillomas, respiratory epithelial adenomatoid hamartoma, seromucinous hamartoma and low-grade non-intestinal adenocarcinoma. There is considerable overlap in their clinical presentation, endoscopic appearance, and imaging features. Although well-described diagnostic criteria exist, a definitive diagnosis may be difficult to reach on a small biopsy. Schneiderian papillomas are divided into fungiform, inverted, and oncocytic types, each with characteristic clinical and morphological features. The latter two may progress to malignancy. The majority are still considered to be HPVrelated. Two lesions are designated as hamartomas, but their pathogenesis remains uncertain, with inflammatory and neoplastic origins proposed. Respiratory epithelial adenomatoid hamartoma is increasingly being recognized for its association with chronic rhinosinusitis and olfactory cleft site of origin. Seromucinous hamartoma has gained attention in recent years and overlaps with both respiratory epithelial adenomatoid hamartoma and low-grade non-intestinal adenocarcinoma. Controversy surrounds their distinction, particularly from low-grade adenocarcinoma. The latter generally is cured by complete excision, with a 26 % risk of recurrence but rare metastases and deaths from disease.

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Section: Treatment and Prognosismentioning

confidence: 99%

Low-Grade Epithelial Proliferations of the Sinonasal Tract

Bullock

2016

Head and Neck Pathol

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“…[12] Bir meta-analizde 76 çalışma-nın sonuçları derlenmiş ve farklı coğrafik bölgelerden 1956 olguda farklı çalışma yöntemleri ile %37.8 HPV pozitif liği saptanmıştır. [11] Kronik enf lamasyon, sigara, [13] Nüks, ilk tedaviden sonra, çoğunlukla aynı yerleşim yerinde, ortalama 31 ayda ortaya çıkmaktadır. [14] Cerrahi tedavinin şekli ile nüks oranları yakından ilişkilidir.…”

Section: Discussionunclassified

A sinonasal inverted papilloma: an evaluation of 38 cases at a single center

Arık¹

2017

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ÖZAmaç: Bu çalışmada, kliniğimizde inverted papillom tanısı konulan hastalar gözden geçirildi ve klinik ve histopatolojik özellikleri sunuldu. Sonuç: Çalışma sonuçlarımız, sinonazal inverted papillomların lokal agresif seyirli, nüks ve malign dönüşüm potansiyelleri olan neoplazmlar olduğunu göstermektedir. Bu nedenle, tedavi radikal cerrahi olmalıdır. Hastalar veAnahtar sözcükler: İnverted papillom; sinonazal papillom; skuamöz hücreli karsinom. ABSTR ACT Objectives:In this study, we review patients with an inverted papilloma who were diagnosed in our clinic and present their clinical and histopathological features. Patients and Methods:A total of 38 patients (31 males, 7 females; mean age 52.2 years; range 16 to 84 years) who were diagnosed with an inverted papilloma in the Department of Pathology of our institution between January 2009 and January 2016 were retrospectively analyzed. Clinical characteristics of the patients, recurrence and malignant transformation rates were evaluated. Results:Of the patients, 17 had right-sided and 18 had leftsided involvement. Three patients had bilateral involvement. A squamous-cell carcinoma developed in four patients. In these patients, the tumor was accompanied by an in situ carcinoma and varying degrees of dysplasia. One patient had severe dysplasia and verrucous hyperplastic changes without an invasive carcinoma. The rate of malignant transformation was found to be 10.5%. Conclusion:Our study results show that sinonasal inverted papillomas are neoplasms with local aggressive course and potential recurrence and malignant transformation. Therefore, treatment should be radical surgery.

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“…The higher incidence of intracranial extension in recurrent IP is due to the technical difficulties in obtaining clearance in these anatomical areas. 1 Anterior cranial fossa invasion occurs after destruction of posterior table of frontal sinus or the roof of nasal cavity. Treatment of choice for IP is wide resection using either an open or endoscopic approach depending upon location and extent of tumour, expertise of surgeon and available technology.…”

Section: Discussionmentioning

confidence: 99%

“…1 It is characterised by an endophytic or inverted growth pattern of epithelium with ramifications into the underlying stroma rather than outward proliferation from the surface with an intact epithelial basement membrane. 2 It affects all ages, most commonly males (M:F 3:1e5:1) in the fifth to the seventh decades of life (average age 53 years).…”

Section: Introductionmentioning

confidence: 99%

“…2 It affects all ages, most commonly males (M:F 3:1e5:1) in the fifth to the seventh decades of life (average age 53 years). 1,3 The most frequent sites are the lateral nasal wall near the middle turbinate or ethmoid recesses and the maxillary sinuses. Although a benign lesion, IP is characterised by its relatively high recurrence rate, local aggressiveness and potential for malignant transformation.…”

Section: Introductionmentioning

confidence: 99%

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