Sinonasal malignancies in children: A 10-year, single-institutional review

Zevallos, José P.; Jain, Kunal; Roberts, Dianna B.; El‐Naggar, Adel K.; Hanna, Ehab Y.; Kupferman, Michael E.

doi:10.1002/lary.21793

Cited by 11 publications

(10 citation statements)

References 9 publications

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“…RMS is a rare soft tissue tumor with a poor prognosis and only modest change in survival in the past 30 years . Despite its rarity, RMS is the most common pediatric soft tissue head and neck malignancy and the most common pediatric malignancy presenting in the sinonasal tract . Previous studies have suggested that parameningeal RMS, which includes that arising from the nasal cavity and paranasal sinuses, has the worst prognosis of all head and neck RMS .…”

Section: Discussionmentioning

confidence: 99%

“…Differences in survival were seen based on primary site, with the maxillary sinus identified as a prognostic factor for increased survival on multivariate regression analysis. The reason is unclear but may be related to differences in clinical presentation, with the maxillary sinus presenting earlier with signs such as facial pain or pressure . Regardless, histology seems to play a lesser role in the prognosis of sinonasal RMS in pediatric patients, whereas primary site may be more instrumental.…”

Section: Discussionmentioning

confidence: 99%

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Clinicopathologic traits and prognostic factors associated with pediatric sinonasal rhabdomyosarcoma

Siddiqui

Bavier

et al. 2019

Int Forum Allergy Rhinol

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Background:Pediatric sinonasal rhabdomyosarcoma (RMS) is an aggressive and rare malignancy. This is the first multi-institutional study on the prognostic factors associated with outcomes in this population. Methods:The National Cancer Database was queried for the period from 2004 to 2013 for all cases of malignant sinonasal RMS in the pediatric population. The impact of patients' demographics, tumor characteristics, and Intergroup Rhabdomyosarcoma Study Group (IRSG) staging on survival was assessed using chi-square test, Fisher's exact test, Kaplan-Meier test, and Cox regression analyses. Results:A total of 157 cases of pediatric sinonasal RMS were identified. Mean age at diagnosis was 9.38 years and male patients comprised 48.4% of the cohort. The nasal cavity (31.8%) and maxillary sinus (30.6%) were the most common primary sites. Alveolar was the most common histology (49.7%), followed by embryonal type (32.5%). The majority of patients received solely chemoradiation (52.9%), followed by surgery with adjuvant chemoradiation (30.6%). Five-year overall survival (OS) was 55.2% (±4.5%). Metastatic disease was associated with a poorer 5-year OS rate (24.4% vs 61.5%; p = 0.010). Maxillary sinus site was associated with an improved survival (71.8% vs 47.6%; p = 0.009). On multivariate analysis, chemoradiation with or without surgery was an additional prognostic factor. Although IRSG clinical stages did not correlate with survival, high-risk patients in the IRSG clinical risk groups were associated with poorer survival on multivariate analysis (hazard ratio [HR], 2.005; 95% confidence interval, 1.007-3.993; p = 0.048). Conclusion:To date, this is the largest study on pediatric sinonasal RMS. IRSG clinical risk groups may be useful in stratifying high-risk patients with poor prognosis. C 2019 ARS-AAOA, LLC. How to Cite this Article: Siddiqui SH, Siddiqui E, Bavier RD, et al. Clinicopathologic traits and prognostic factors associated with pediatric sinonasal rhabdomyosarcoma. Int Forum Allergy Rhinol. 2019;9:363-369. R habdomyosarcoma (RMS) is a soft tissue malignancy that compromises 2.9% of all pediatric cancer in

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Clinicopathologic traits and prognostic factors associated with pediatric sinonasal rhabdomyosarcoma

Siddiqui

Bavier

et al. 2019

Int Forum Allergy Rhinol

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“…Squamous carcinomas, adenoid cystic carcinomas, and salivary gland malignancies are treated by open surgical resection with adjuvant radiotherapy. The outcomes among patients with carcinomas, sarcomas, and esthesioneuroblastomas are not significantly different; previous research has shown that the overall survival, disease‐specific survival, and recurrence are the same …”

Section: Managementmentioning

confidence: 92%

“…Sinonasal malignancies in children include carcinomas, sarcomas, and esthesioneuroblastomas. The most common tumor site is the maxillary sinus, and most of these tumors are rhabdomyosarcomas . Primary surgery includes endoscopic resection and open surgical resection.…”

Section: Managementmentioning

confidence: 99%

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Multidisciplinary approach to children with sinonasal tumors: A review

Lazim¹,

Abdullah²

2019

Pediatric Investigation

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Sinonasal tumors in children are rare and difficult to manage. These tumors can be broadly categorized into congenital or acquired and benign or malignant. The tumors mainly arise from the mucosa, cartilage, or bone of the nasal cavity and may occupy areas of the nasal septum, turbinates, osteomeatal complex, sinuses, and nasopharynx. The management of pediatric sinonasal tumors is challenging, especially in cases of malignancy. Malignant tumors pose a treatment dilemma because most such tumors tend to be aggressive and carry a poor prognosis. Multiple complications associated with the primary disease or treatment may occur, and such complications need to be fully addressed to provide optimal care. In most cases, a multidisciplinary team approach will offer the best possible outcome for children with sinonasal tumors.

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