Sinonasal melanoma arising from conjunctival primary acquired melanosis

Abstract

SUMMARYA 66-year-old woman was treated with excision and cryotherapy for recurrent primary acquired melanosis (PAM) with atypia of the right conjunctiva. Four years later, she developed a melanoma of the ipsilateral inferior turbinate and nasolacrimal duct. She was treated with right medial maxillectomy and postoperative radiation therapy. This is the first reported case of conjunctival PAM resulting in delayed progression to melanoma in the nasolacrimal duct and sinonasal cavity. BACKGROUND

Bone metastasis in a case of primary acquired melanosis with atypia resulting from conjunctiva melanoma

“… 13 Furthermore, involvement of the palpebral conjunctiva, fornix, caruncle or plica location, and corneal involvement were also found to have an increased risk in progression towards melanoma. 2 , 3…”

“…Primary acquired melanosis (PAM) is a benign but premalignant pigmented conjunctival condition that can occur in middle-aged individuals. It presents as a painless, flat, non-cystic pigmented lesion that can involve the conjunctiva, cornea, and eyelids and occurs mostly in the Caucasian population 1 In general, PAM accounts for 11% of all conjunctival lesions 1 , 2 , 3…”