Sinonasal Non–Intestinal-Type Adenocarcinoma: A Retrospective Review of 22 Patients

Bignami, Maurizio; Lepera, Davide; Volpi, Luca; Lambertoni, Alessia; Arosio, Alberto Daniele; Pistochini, Andrea; Nicolai, Piero; Castelnuovo, Paolo

doi:10.1016/j.wneu.2018.08.201

Cited by 20 publications

(28 citation statements)

References 31 publications

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“…Bhaijee et al reported one case of LG non-ITAC originating in the nasal cavity (12). However, Bignami et al reported that the tumor originated in the ethmoid sinus in 9 (39%) of 13 patients, with the tumor arising in the nasal cavity in the remaining cases (6). In our case, the ethmoid sinus was identified as the origin based on the results of examinations after chemoradiotherapy.…”

Section: Discussionmentioning

confidence: 56%

“…LG non-ITAC is very uncommon. Thus, far, only two studies have reported the clinical and therapeutic aspects of LG non-ITAC (6,12). We performed a search of the PubMed and Ichushi databases using the following search term, "sinonasal, low-grade, non-intestinal adenocarcinoma."…”

Section: Discussionmentioning

confidence: 99%

“…Choussy et al reported 418 patients with ethmoid sinus adenocarcinoma who showed a worse prognosis when the lesion reached the sphenoid sinus (7). Bignami et al pointed out that LG non-ITAC showed a better prognosis compared with HG non-ITAC, and within the LG non-ITAC group, patients with T4a and T4b tumors had worse outcomes than those with T1 to T3 tumors (6). Approximately 25% of patients with LG non-ITAC develop recurrent disease, and 6% die from the tumor, usually as a result of the loss of local control (5).…”

Section: Discussionmentioning

confidence: 99%

“…Based on the WHO classification in 2017, sinonasal adenocarcinoma is categorized into intestinal and non-intestinal types (5). In contrast to intestinal-type adenocarcinoma (ITAC), which is associated with wood and leather dust exposure, non-intestinal type adenocarcinoma (non-ITAC) is not associated with any environmental factors (6). Non-ITAC is further classified into low-grade (LG) non-ITAC and high-grade (HG) non-ITAC (5,6).…”

Section: Introductionmentioning

confidence: 99%

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Case Report: Response to Intra-arterial Cisplatin and Concurrent Radiotherapy Followed by Salvage Surgery in a Patient With Advanced Primary Sinonasal Low-Grade Non-intestinal Adenocarcinoma

et al. 2020

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Background: The clinical usefulness of concurrent chemoradiotherapy before surgery in the treatment of primary, locally advanced sinonasal low-grade, non-intestinal type adenocarcinoma (LG non-ITAC) is unclear.Methods: We present the first case report of the efficacy of super-selective intra-arterial cisplatin (CDDP) infusion concurrent with conventional fractionated radiotherapy (RT) for LG non-ITAC in a Japanese patient.Results: A white, rugged-marginal mass that was histopathologically diagnosed as LG non-ITAC occupied the right nasal cavity. Based on the imaging findings, including computed tomography, magnetic resonance imaging, and positron emission tomography, the tumor was diagnosed as T4aN0M0, stage IVa. After treatment, the nasal tumor disappeared leaving only a small bulge in the medial wall of the middle turbinate. The patient also underwent right transnasal ethmoidectomy performed as salvage surgery. A histopathological examination revealed that the lesion was replaced by granulation tissue with lymphocytic infiltration and hemosiderin-laden macrophages, and no viable tumor cells remained. In the seven years after treatment, the patient has not experienced any local recurrence or regional or distant metastasis.Conclusions: Super-selective intra-arterial CDDP infusion concurrent with conventional fractionated RT followed by salvage surgery might be useful for the management of sinonasal LG non-ITAC.

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Section: Discussionmentioning

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Case Report: Response to Intra-arterial Cisplatin and Concurrent Radiotherapy Followed by Salvage Surgery in a Patient With Advanced Primary Sinonasal Low-Grade Non-intestinal Adenocarcinoma

et al. 2020

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“…In our cohort, patients with negative surgical margins had increased survival compared with patients who had positive margin, which coincides with other published reports. 17,[19][20][21] This highlights the importance of complete surgical resection with clear margins and may also underscore the benefit of postoperative RT in sinonasal malignancies. In those patients who had positive margins, we did find that patients treated with surgery alone had an increased risk of mortality compared with those who received surgery and adjuvant RT.…”

Section: Discussionmentioning

confidence: 89%

Multi-modality Treatment and Survival in Sinonasal Minor Salivary Gland Tumors

et al. 2019

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Objectives The aim of this study was to analyze the effect of the multimodality treatment on survival in sinonasal minor salivary gland tumors. Methods Adult clinical American Joint Committee on Cancer (AJCC) tumor (T) 1-4a staged cases of sinonasal minor salivary gland tumors were isolated from the National Cancer Database (2004–2014). Multivariate regressions were performed to analyze the effect of multimodality treatment. A subset analysis was also performed in patients with positive margins following surgical management. Results We identified 556 cases, of which 293 (52.7%) patients were treated with surgery and radiotherapy (RT), 160 (28.8%) were treated with surgery alone, and 52 (9.4%) were treated with surgery and chemoradiotherapy (CRT). No patients were treated with chemotherapy alone. With surgery and CRT as a reference, the only treatment modality associated with decreased survival was RT alone (hazard ratio [HR]: 3.213 [95% confidence interval (CI): 1.578–6.543]; p = 0.001). Within a subset analysis of patients with positive margins, surgery was associated with decreased survival (HR: 2.021 [95% CI: 1.401–3.925]; p = 0.038), but not triple modality therapy (HR: 1.700 [95% CI: 0.798–3.662]) when compared with surgery with RT. Conclusion The most common treatment was surgery and RT, consistent with National Comprehensive Cancer Network (NCCN) guidelines which recommends chemotherapy (CT) only in the most concerning cases. However, we found no difference in survival among most treatment modalities when compared with triple modality therapy, with the exception of RT alone. Although margins were prognostic within these cancers, we found no evidence that adjuvant CRT provides any survival benefit over surgery and RT, though surgery alone was associated with decreased survival.

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International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors

Kuan

Wang

Adappa

et al. 2024

Int Forum Allergy Rhinol

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BackgroundSinonasal neoplasms, whether benign and malignant, pose a significant challenge to clinicians and represents a model area for multidisciplinary collaboration in order to optimize patient care. The International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors (ICSNT) aims to summarize the best available evidence and presents 48 thematic and histopathology‐based topics spanning the field.MethodsIn accordance with prior ICAR documents, ICSNT assigned each topic as an Evidence‐Based Review with Recommendations, Evidence‐Based Review, and Literature Review based on level of evidence. An international group of multidisciplinary author teams were assembled for the topic reviews using the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses format, and completed sections underwent a thorough and iterative consensus‐building process. The final document underwent rigorous synthesis and review prior to publication.ResultsThe ICNST document consists of 4 major sections: general principles, benign neoplasms and lesions, malignant neoplasms, and quality of life and surveillance. It covers 48 conceptual and/or histopathology‐based topics relevant to sinonasal neoplasms and masses. Topics with a high level of evidence provided specific recommendations, while other areas summarized the current state of evidence. A final section highlights research opportunities and future directions, contributing to advancing knowledge and community intervention.ConclusionAs an embodiment of the multidisciplinary and collaborative model of care in sinonasal neoplasms and masses, ICSNT was designed as a comprehensive, international, and multidisciplinary collaborative endeavor. Its primary objective is to summarize the existing evidence in the field of sinonasal neoplasms and masses.This article is protected by copyright. All rights reserved

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Sinonasal Non–Intestinal-Type Adenocarcinoma: A Retrospective Review of 22 Patients

Cited by 20 publications

References 31 publications

Case Report: Response to Intra-arterial Cisplatin and Concurrent Radiotherapy Followed by Salvage Surgery in a Patient With Advanced Primary Sinonasal Low-Grade Non-intestinal Adenocarcinoma

Case Report: Response to Intra-arterial Cisplatin and Concurrent Radiotherapy Followed by Salvage Surgery in a Patient With Advanced Primary Sinonasal Low-Grade Non-intestinal Adenocarcinoma

Multi-modality Treatment and Survival in Sinonasal Minor Salivary Gland Tumors

International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors

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