Sinonasal teratocarcinosarcoma: a case report and literature review

Abstract

Background Sinonasal teratocarcinosarcoma (SNTCS) is a highly invasive malignant tumor most frequently found in the nasal cavity and paranasal sinuses. As a result, it can be confused with other sinonasal tumors. In addition, SNTCS progresses rapidly and often infiltrates other tissues or organs in the early phase, resulting in poor patient prognosis. The objective of this article was to report the case of a patient with SNTCS and discuss the management strategy. Furthermore, we conducted a literature review for SNTCS and summarized the findings from 107 cases. Case presentation: Here, we report a 47-year-old man diagnosed with SNTCS and treated with radiochemotherapy after an initial operation. After follow-up for 5 years, no tumor recurrence was observed. Conclusions As SNTCS progresses rapidly, early diagnosis and surgical treatment combined with radiochemotherapy can improve patient survival.

Sinonasal teratocarcinosarcoma: a therapeutic dilemma

“…They found that the primary treatments used in those patients were surgical resection (87.2%), radiation therapy (59.3%) and chemotherapy (18.6%). 7 The main treatment option is surgery, with negative margins. However, due to the anatomical complexity of the nasal sinuses, surgery does not always achieve complete tumour resection with negative margins; as such, neoadjuvant chemoradiotherapy plus surgical resection is the recommended therapy, with a nearly 88% survival rate after an average of 32 months, as compared with patients treated with surgery and radiation only, who had a 56.5% survival rate at 45 months.…”

“…It included 107 SNTCS cases (from 1968 to 2020). They found that the primary treatments used in those patients were surgical resection (87.2%), radiation therapy (59.3%) and chemotherapy (18.6%) 7. The main treatment option is surgery, with negative margins.…”

Teratocarcinosarcoma of the head and neck: Clinicopathologic review of a rare entity

“…[7][8][9] It shows a striking male predominance (approximately 83% of patients) with a male-to-female ratio of 7:1. [6][7][8] The most common site of involvement is the superior aspect of the nasal cavity (approximately 79% of cases) with a predominance of the left side, followed by, in decreasing order of frequency, the paranasal sinuses, orbit, nasopharynx, pharyngeal wall, skull base, cribriform plate, and anterior cranial fossa. 1,6,7,[9][10][11] Nevertheless, rapid growth and extensive local destruction with direct extension into adjacent structures are frequently encountered at the time of diagnosis, and the site of origin cannot be determined in some cases.…”

“…[6][7][8] The most common site of involvement is the superior aspect of the nasal cavity (approximately 79% of cases) with a predominance of the left side, followed by, in decreasing order of frequency, the paranasal sinuses, orbit, nasopharynx, pharyngeal wall, skull base, cribriform plate, and anterior cranial fossa. 1,6,7,[9][10][11] Nevertheless, rapid growth and extensive local destruction with direct extension into adjacent structures are frequently encountered at the time of diagnosis, and the site of origin cannot be determined in some cases. 1,6 Although TCS shows a predilection for the sinonasal tract, in rare cases, tumors showing features resemble TCS have been reported to arise primarily in the thyroid gland and oral cavity.…”

Correlative imaging and histopathology of a complicated sinonasal teratocarcinosarcoma

“…Inadequate sampling may lead to erroneous diagnoses of olfactory neuroblastoma, squamous cell carcinoma, undifferentiated carcinoma, adenocarcinoma, malignant salivary gland–type tumours and adenosquamous carcinoma. 5 , 8 …”