Sinonasal Undifferentiated Carcinoma Invading the Orbit

Ascaso, Francisco J.; Adiego, M. I.; Garcia, J.; Royo, José Luis; Valles, H.; Palomar, A; Cajal, Santiago Ramón y

doi:10.1177/112067219400400408

Cited by 11 publications

(4 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…When all patients were classified using Kadish staging, 52 of 167 (31.1%) of the patients had disease contained within the sinuses, 35 of 167 (21.0%) had disease that invaded beyond the sinuses, and 65 of 167 (38.9%) had disease involving the apex of the orbit, the skull base, or the brain. 19 1990 Deutsch 3 1993 Kapadia 20 1993 Ascaso 21 1994 Gallo 22 1995 Leung 23 1995 Pitman 24 1995 Righi 4 1996 Houston 25 1998 Kerrebijn 5 1998 Gorelick 6 2000 Miyamoto 26 2000 Smith 7 2000 Sakamoto 27 2001 Sharara 15 Follow-up ranged from 1 to 195 months (mean 23.4 months, median 15 months). Table 3 shows the distribution of patients in the described cohorts and their treatment.…”

Section: Resultsmentioning

confidence: 99%

Meta‐analysis of Treatment Outcomes for Sinonasal Undifferentiated Carcinoma

Reiersen¹,

Pahilan

Devaiah³

2012

Otolaryngol.--head neck surg.

105

115

View full text Add to dashboard Cite

show abstract

Section: Resultsmentioning

confidence: 99%

Meta‐analysis of Treatment Outcomes for Sinonasal Undifferentiated Carcinoma

Reiersen¹,

Pahilan

Devaiah³

2012

Otolaryngol.--head neck surg.

105

115

View full text Add to dashboard Cite

show abstract

“…Soft tissue, bone, and cartilaginous tumors accounted for 13% of the cases, and only 5% were neuroendocrine tumors. [1][2][3][4][5][6][7][8] FIG. 1.…”

Section: Discussionmentioning

confidence: 99%

Orbital Involvement by Biphenotypic Sinonasal Sarcoma With a Literature Review

Hanbazazh

Curtin

Lefebvre

2020

Ophthalmic Plastic &Amp; Reconstructive Surgery

View full text Add to dashboard Cite

Purpose: To document a case of a biphenotypic sinonasal sarcoma that impinged on the orbit via a tumor-induced mucocele and review the previous literature devoted to this condition. Methods: A clinicopathologic case report with detailed histopathologic, immunohistochemical, and radiological studies with tabulations of previously reported cases and immunohistochemical stains for ruling out mimicking lesions. Results: A biphenotypic sinonasal sarcoma arose from the ethmoid sinus in a middle-aged man. The tumor induced a mucocele that bowed the medial orbital lamina papyracea into the orbit and caused diplopia and mild proptosis. The biopsy’s dual positivity for S100 and smooth muscle actin together with positive paired box 3 immunohistochemical staining established the diagnosis of biphenotypic sinonasal sarcoma. Conclusion: Biphenotypic sinonasal sarcoma, which can involve the orbit in 25% of cases, is a rare head and neck malignancy that has only recently been described. Biphenotypic sinonasal sarcoma is a low-grade, locally aggressive, nonmetastasizing sarcoma displaying both neural and muscle differentiation. It is further characterized by rearrangements of the PAX3 gene with multiple fusion partners, most commonly MAML3 (Mastermind like transcriptional coactivator 3). It occurs predominantly in middle-aged women and exclusively in the sinonasal tract. However, it can spread throughout the central facial structures to invade the brain if not detected early. Ophthalmologists should be aware of this new entity to avoid delays in diagnosis and treatment. The previous literature devoted to this condition was reviewed and analyzed for clinical, radiological, histopathological, and immunohistochemical features. In circumstances where molecular testing is not available, paired box 3 immunohistochemical staining can be used as an alternative diagnostic marker. The current case is most unusual because the orbital findings were induced by a mucocele caused by the tumor that obstructed the sinus ostium. This produced diplopia without direct tumor invasion into the orbital fat.

show abstract

“…Hence, the diagnosis of SNUC relies on examining tissue samples histopathologically, often involving immunohistochemical analysis. It is a highly aggressive neoplasm, with patients presenting to clinical attention at a very advanced stage, where fundamental structures of the skull base, brain, and orbit are already involved [ 9 ]. The initial symptoms of SNUC can seem harmless, like nasal blockage, nosebleeds, headaches, and facial discomfort.…”

Section: Introductionmentioning

confidence: 99%

“…The initial symptoms of SNUC can seem harmless, like nasal blockage, nosebleeds, headaches, and facial discomfort. However, they may also manifest as vision problems, swelling around the eyes, proptosis, and cranial nerve palsies [ 9 ]. Cervical lymph nodes are involved in 10–30% of patients at the time of clinical presentation.…”

Section: Introductionmentioning

confidence: 99%

Complex Craniofacial Cases through Augmented Reality Guidance in Surgical Oncology: A Technical Report

Tel,

Raccampo,

Vinayahalingam

et al. 2024

Diagnostics

View full text Add to dashboard Cite

Augmented reality (AR) is a promising technology to enhance image guided surgery and represents the perfect bridge to combine precise virtual planning with computer-aided execution of surgical maneuvers in the operating room. In craniofacial surgical oncology, AR brings to the surgeon’s sight a digital, three-dimensional representation of the anatomy and helps to identify tumor boundaries and optimal surgical paths. Intraoperatively, real-time AR guidance provides surgeons with accurate spatial information, ensuring accurate tumor resection and preservation of critical structures. In this paper, the authors review current evidence of AR applications in craniofacial surgery, focusing on real surgical applications, and compare existing literature with their experience during an AR and navigation guided craniofacial resection, to subsequently analyze which technological trajectories will represent the future of AR and define new perspectives of application for this revolutionizing technology.

show abstract

Sinonasal Undifferentiated Carcinoma Invading the Orbit

Cited by 11 publications

References 4 publications

Meta‐analysis of Treatment Outcomes for Sinonasal Undifferentiated Carcinoma

Meta‐analysis of Treatment Outcomes for Sinonasal Undifferentiated Carcinoma

Orbital Involvement by Biphenotypic Sinonasal Sarcoma With a Literature Review

Complex Craniofacial Cases through Augmented Reality Guidance in Surgical Oncology: A Technical Report

Contact Info

Product

Resources

About