Síntese, Caracterização E Avaliação Da Atividade Citotóxica De Compostos Ciclopaladados Contendo Como Ligantes Benzaldeidoxima Ortometalada E Etilenotiouréia

Abstract

SYNTHESIS, CHARACTERIZATION AND CYTOTOXIC ACTIVITY EVALUATION OF CYCLOPALLADATED COMPOUNDS CONTAINING ORTHOMETALLATED BENZALDEHYDEOXIME AND ETHYLENETHIOUREA AS LIGANDS. The halidebridge cleavage reaction of the [Pd(C 2 ,N-bzox)(µ-Cl)] 2 compound (bzox = benzaldehydeoxime) with ethylenethiourea (L) in the 1:2 molar ratio at room temperature yielded the cyclopalladated compound [Pd(C 2 ,N-bzox)(Cl)(L)] (1) whose replacement of the halide group by the addition of suitable salts afforded compounds of general formulae [Pd(C 2 ,N-bzox)(X)(L)] {X = Br-(2), I-(3)}. All compounds were characterized by melting point, elemental analyses, infrared and 1 Hand 13 C{ 1 H}-NMR spectroscopies revealing the complexes formation with the oxime coordinated to Pd(II) as C,N-chelating and the ethylenethiourea as a monodentate ligand via the sulfur atom. The cytotoxicity of cyclopalladated compounds has been evaluated in vitro against murine mammary tumor cell (LM3) showing cytotoxic activity similar to cisplatin.