Síntese de copolímeros metacrílicos através da modificação química do poli(metacrilato de metila) de massa molar Controlada

César-Oliveira, Maria A. F.; Zaioncz, Soraia; Oliveira, Angelo R. S.; Almeida, Maria C. R.; Zawadzki, Sônia Faria; Akcelrud, Leni; Aguiar, Marcos Fábio Porto de; Tabak, David; Lucas, Elizabete F.

doi:10.1590/s0104-14281999000400026

Cited by 15 publications

(9 citation statements)

References 7 publications

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“…The peaks in the region of 0.6-1.0 ppm can be attributed to the hydrogens of the methyl group, whose chemical shift is influenced by the tacticity of the polymer. [42] The peak at 0.64 ppm arises from the methyl of the syndiotactic triad, while the peak at 0.84 ppm is due to the heterotactic triad. [43,44] …”

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confidence: 99%

Synthesis of mid-chain functional macrophotoinitiators of poly(D,L-lactide) homopolymer and tetrablock poly(D,L-lactide)-poly(ε-caprolactone) copolymer by ring-opening polymerization

Degirmenci

Urun

Durgun

et al. 2015

Designed Monomers and Polymers

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We have synthesized novel biobased and environmental friendly mid-chain functional macrophotoinitiators of poly(D,L-lactide) homopolymer (PDLLA-PI-PDLLA) and tetrablock poly(D,L-lactide)-poly(ε-caprolactone) copolymer (PDLLA-PCL-PI-PCL-PDLLA) with controlled molecular weights and narrow molecular weight distributions via ring-opening polymerization (ROP). Mid-chain functional poly(D,L-lactide) (PDLLA-PI-PDLLA) macrophotoinitiator was prepared by ROP of D,L-lactide (DLLA) monomer using a dihydroxy-functional photoinitiator (HO-PI-OH) as the initiator and stannous-2-ethyl hexanoate (Sn(Oct) 2 ) as the catalyst. Tetrablock poly(D,L-lactide)-poly(ε-caprolactone) copolymer (PDLLA-PCL-PI-PCL-PDLLA) with a mid-chain photofunctional group was synthesized via sequential ROP of ε-caprolactone and D,L-lactide using Sn(Oct) 2 as the catalyst. The resultant polymers were fully characterized by means of 1 H NMR, FTIR, UV-vis, Fluorescence, and GPC techniques. The obtained macrophotoinitiators were used as a prepolymer in photoinitiated free radical polymerization for obtaining AB-type diblock copolymer and ABC-type triblock terpolymer.

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confidence: 99%

Synthesis of mid-chain functional macrophotoinitiators of poly(D,L-lactide) homopolymer and tetrablock poly(D,L-lactide)-poly(ε-caprolactone) copolymer by ring-opening polymerization

Degirmenci

Urun

Durgun

et al. 2015

Designed Monomers and Polymers

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“…Furthermore, bands located around 2900 cm −1 and 1100 cm −1 are characteristic of the hydroxyl groups and C‐O bond, from carboxylic acid and ester chemical functions, respectively . Absorption peaks placed at 3300–3100 cm −1 and 1700–1600 cm −1 , typical of amide bonds, might be expected in the functionalized materials if chemical bonding had occurred . However, the obtained spectra of functionalized particles (Figure ‐b) did not reveal the existence of these bands, confirming functionalization through adsorption of BSA.…”

Section: Resultsmentioning

confidence: 92%

“…FT‐IR analysis were performed before and after functionalization with BSA. Initial spectra (Figure ‐a) showed the existence of intense absorption peaks around 1720 cm −1 , which can be assigned to the carbonyl group of carboxylic acid and ester chemical groups . Furthermore, bands located around 2900 cm −1 and 1100 cm −1 are characteristic of the hydroxyl groups and C‐O bond, from carboxylic acid and ester chemical functions, respectively .…”

Section: Resultsmentioning

confidence: 99%

Production and Functionalization of P(MMA‐co‐AA) Nanoparticles by Miniemulsion Polymerization

Campos

Ferraz

Pinto

2016

Macromolecular Symposia

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Summary In the present work, the production of poly(methyl methacrylate‐co‐acrylic acid), P(MMA‐co‐AA), nanoparticles and the subsequent functionalization through immobilization of BSA (bovine serum albuminum) and lysine were investigated. Nanoparticles produced presented average size of 100 nm, zeta potential of −40 mV and AA content ranging from 1 to 10 mol%. Particularly, it was shown that inespecific physical interactions control the adsorption of BSA onto the particle surfaces. On the other hand, lysine was covalently bonded to the nanoparticles, producing particles with more negative zeta potentials and leading to larger rates of immobilization. These results can be related to the smaller size of the aminoacid molecule and to the much higher availability of amino groups during the aminoacid immobilization, indicating that the size of the biomolecular signals must be taken into consideration during functionalization of nanoparticles for use in targeted delivery applications.

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“…Os reagentes fosfito de dipropila, fosfito de dibutila, fosfito de diisobutila, fosfito de diisopropila e fosfito de diisopentila foram sintetizados pelo nosso grupo de pesquisa [10][11][12] . [15,16] A obtenção do copolímero graftizado foi realizada a partir da adaptação da metodologia descrita segundo Novack e Oliveira [17] . O copolímero foi preparado em béquer a partir da dissolução de 40,00g de polietilenoglicol em 100,00 mL de diclorometano.…”

Section: Reagentes Químicosunclassified

Síntese e caracterização de novos copolímeros fosforilados

et al. 2015

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ResumoO rápido desenvolvimento da química de polímeros nos últimos anos tem acompanhado a introdução dos materiais poliméricos no campo da medicina. Polímeros com aplicações médicas podem ser subdivididos em dois grandes grupos: materiais usados em próteses e a produção de polímeros biologicamente ativos. Neste trabalho foram sintetizados copolímeros possuindo cadeia principal de poli (metacrilato de metila) e cadeias enxertadas de polietilenoglicol (COP GRAFT). A partir da síntese do copolímero enxertado inicial foram realizadas modificações em suas cadeias de modo a aumentar a possibilidade de incorporação de um fármaco que será utilizado em sistema de liberação controlada de medicamentos. Os novos compostos foram obtidos através de duas rotas sintéticas e os produtos formados ao final de cada etapa foram purificados e caracterizados. Através da técnica de infravermelho (FITIR) foi possível observar as bandas de absorções características das ligações P-H, P=O e P-O, que foram inseridas na cadeia do COP GRAFT durante a fosforilação, além das bandas de absorções características do copolímero, antes da fosforilação, como C=O e C-O. A caracterização térmica das amostras utilizando termogravimetria (TGA) e calorimetria diferencial de varredura (DSC) mostrou que apenas o copolímero de diisobutila apresentou temperatura de transição endotérmica e comportamentos de degradação compatíveis a de um polímero. Através da técnica de difração de raios X (XRD) foi possível observar uma modificação da cristalinidade das amostras, provavelmente devido a uma variação da conformação das cadeias após a inserção de novos grupos químicos. Nos cromatogramas obtidos pela técnica de cromatografia de permeação em gel (GPC) percebeu-se aumento de massa após a fosforilação com o grupo diisobutila no COPGRAFT. A reação de fosforilação foi eficiente na obtenção do copolímero de diisobutila e as técnicas aplicadas demonstraram que houve a modificação no copolímero enxertado. Palavras-chave: síntese e modificação de copolímero, fosforilação, caracterização por FTIR, DSC, TGA, XRD e GPC. AbstractThe rapid development in polymer chemistry has, in recent years, led to the introduction of polymeric materials in the field of medicine. Two major groups of polymers are used for medical applications: prosthetic and biologically active materials. We synthesized copolymers with the main chain consisting of poly (methyl methacrylate) and graft chains of poly(ethylene glycol) (COP GRAFT). Changes were made in the graft copolymer chains for a possible incorporation of a drug, such that it may be used for the controlled release of drugs. The synthesis of these new compounds is based on two synthetic routes and FTIR, differential scanning calorimetry (DSC), thermogravimetry (TGA) and X-ray diffraction (XRD) characterized the products formed at the end of each stage. Through FTIR we observed absorption bands characteristic of P-H, P=O and P-O bonds that were inserted into the polymer chain during phosphorylation of the COP GRAFT, beyond the absorption bands ...

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Síntese de copolímeros metacrílicos através da modificação química do poli(metacrilato de metila) de massa molar Controlada

Cited by 15 publications

References 7 publications

Synthesis of mid-chain functional macrophotoinitiators of poly(D,L-lactide) homopolymer and tetrablock poly(D,L-lactide)-poly(ε-caprolactone) copolymer by ring-opening polymerization

Synthesis of mid-chain functional macrophotoinitiators of poly(D,L-lactide) homopolymer and tetrablock poly(D,L-lactide)-poly(ε-caprolactone) copolymer by ring-opening polymerization

Production and Functionalization of P(MMA‐co‐AA) Nanoparticles by Miniemulsion Polymerization

Síntese e caracterização de novos copolímeros fosforilados

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