Síntomas abdominales y gastrointestinales del dengue. Análisis de una cohorte de 8.559 pacientes

Medina, Antonio Ramos-De la; Troche, José María Remes; González-Medina, María Fernanda; Anitúa-Valdovinos, María del Mar; Cerón, Tadeo; Zamudio, Claudio; Díaz-Vega, Aurora

doi:10.1016/j.gastrohep.2011.01.012

Cited by 20 publications

(10 citation statements)

References 17 publications

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“…In an epidemiological study of dengue in school children at Ratchaburi, Thailand from 2006 to 2008, diarrhea was seen in 17.1% and 50.0% of DF and DHF patients, respectively [16]. A study of gastrointestinal manifestations in patients with dengue infection in the 2006 dengue epidemic in Mexico, diarrhea was found in 24% of 1,640 hospitalized patients [17]. In our study, we found diarrhea in 28.8%.…”

Section: Discussionsupporting

confidence: 53%

Unusual clinical manifestations of dengue infection in children in a tertiary care hospital in northeast Thailand

2014

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Background: Dengue virus infection has been a public health concern in Thailand. In the past decades, there has been recent interest concerning unusual clinical manifestations in both dengue fever (DF) and dengue hemorrhagic fever (DHF).Objective: We described the unusual clinical manifestations and outcomes of children with dengue admitted to a tertiary care hospital in northeast Thailand.Materials and Methods: A study was conducted on the 73 patients with serologically confirmed dengue infection admitted to Srinagarind Hospital, a tertiary care facility in northeast Thailand between January 2007 and August 2011.Results: Of the 73 children examined, 42 (57%) were boys and 31 were girls. Their age ranged from 8 months to 14 years (median 11 years). Nine patients developed neurological symptoms, 6 patients had altered consciousness, and 3 patients convulsion. Among 9 patients with neurological symptoms, 1 patient had acute kidney injury, 1 had hepatic failure, and 1 had kidney and liver involvement, mostly associated with fluid resuscitation or prolonged shock. Apart from neurological symptoms, one patient developed infection associated hemophagocytic syndrome and was treated with intravenous immunoglobulin. Two patients died from multiple organ failure, and 1 patient was brought back home in a moribund condition. The other patients recovered completely.Conclusion: Altered consciousness was the most commonly observed unusual neurological manifestation. Patients who did not develop acute kidney injury or liver failure had mild clinical courses and recovered from neurological symptoms without sequelae. Acute kidney injury was associated with fluid overload and/or prolonged shock. Careful fluid management and close monitoring for complications resulted in favorable outcomes.

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Section: Discussionsupporting

confidence: 53%

Unusual clinical manifestations of dengue infection in children in a tertiary care hospital in northeast Thailand

2014

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“…We found DVI-associated diarrhea in 9/39 (23.1%) patients, which was similar to previous studies which found rates of DVI-associated diarrhea of 17–35% [29], [30]. One study in adult patients found that patients who had DVI-associated diarrhea were more likely to have more severe DVI compared to those who had no diarrhea [31].…”

Section: Discussionsupporting

confidence: 90%

Is Zinc Concentration in Toxic Phase Plasma Related to Dengue Severity and Level of Transaminases?

Laoprasopwattana

Tangcheewawatthanakul

Tunyapanit

et al. 2013

PLoS Negl Trop Dis

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ObjectiveTo determine the relationship between plasma zinc values and the severity of dengue viral infection (DVI) and DVI-caused hepatitis.MethodsA prospective cohort study was conducted during 2008–2010 in hospitalized children aged <15 years confirmed with DVI. Complete blood count, aspartate aminotransferase (AST), alanine aminotransferase (ALT), and zinc values (mcg/dL) were determined twice: first during the toxic phase (Zn1) and secondly two weeks after recovery (Zn2).Results39 patients were enrolled with a mean age of 9.7±3.7 years, and 15/39 diagnosed with dengue shock syndrome (DSS). Zn1 values were lower than Zn2 values [median (IQR): 46.0 (37.0, 58.0) vs 65.0 (58.0, 81.0) mcg/dL, respectively, p <0.01]. Zn1 but not Zn2 values had a negative correlation with AST and ALT (rs = −0.33, p = 0.04 and rs = −0.31, p = 0.05, respectively). Patients with DSS had lower Zn1 but not Zn2 values compared with non-DSS patients [median (IQR) Zn1, 38.0 (30.0, 48.0) vs 52.5 (41.2, 58.7), p = 0.02; Zn2, 61.0 (56.0, 88.0) vs 65.0 (59.5, 77.5), respectively, p = 0.76]. Zn1 values showed a decreasing trend across increasing dengue severity groups (p = 0.02). Age <5 years and DVI-associated diarrhea were associated with low Zn1.ConclusionChildren who had a higher grade of dengue disease severity and liver cell injury had lower Zn1 values. Low Zn1 values were probably caused by loss from diarrhea and from zinc translocating to liver cells.

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“…In healthy individuals, the frequency of main dengue symptoms diverges according to different authors . In the present study, the frequency of symptoms was similar to what has been described in non‐immunocompromised patients, except for arthralgia, as shown in Table .…”

Section: Discussionsupporting

confidence: 88%

Prolonged viremia in dengue virus infection in hematopoietic stem cell transplant recipients and patients with hematological malignancies

Pereira

Darrigo

Costa

et al. 2017

Transplant Infectious Dis

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Fever, skin rash, headache, and thrombocytopenia are considered hallmarks of dengue infection. However, these symptoms are frequently observed in infectious and non-infectious complications of hematopoietic stem cell transplant recipients and oncohematological patients. Thus, laboratory confirmation of dengue is relevant for prompt intervention and proper management of dengue in endemic and non-endemic regions. Because no prospective study of dengue has been conducted in these populations, the actual morbidity and mortality of dengue is unknown. In the present series, we describe five cases of dengue in patients living in endemic areas, emphasizing the prolonged course of the disease and the occurrence of prolonged viremia.

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Síntomas abdominales y gastrointestinales del dengue. Análisis de una cohorte de 8.559 pacientes

Cited by 20 publications

References 17 publications

Unusual clinical manifestations of dengue infection in children in a tertiary care hospital in northeast Thailand

Unusual clinical manifestations of dengue infection in children in a tertiary care hospital in northeast Thailand

Is Zinc Concentration in Toxic Phase Plasma Related to Dengue Severity and Level of Transaminases?

Prolonged viremia in dengue virus infection in hematopoietic stem cell transplant recipients and patients with hematological malignancies

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