Sinus augmentation analysis revised: the gradient of graft consolidation

Busenlechner, Dieter; Huber, Christian D.; Vasak, Christoph; Dobsak, Toni; Gruber, Reinhard; Watzek, Georg

doi:10.1111/j.1600-0501.2009.01733.x

Cited by 79 publications

(100 citation statements)

References 24 publications

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“…This anatomical variation might be related to the different origin of animals previously used. 6,17,[19][20][21][22][23][24] However, BIC values after 6 and 12 weeks were comparable or even higher than in previous studies using the same model. 17,19,22 Due to the very variable but most often limited size of the sinus cavity, the same amount of DBBM (by weight) could not be applied in all surgical sites.…”

Section: Discussionsupporting

confidence: 44%

Influence of Particle Size of Deproteinized Bovine Bone Mineral on New Bone Formation and Implant Stability after Simultaneous Sinus Floor Elevation: A Histomorphometric Study in Minipigs

Jensen

Aaboe

Janner

et al. 2013

Clinical Implant Dentistry and Related Research

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Section: Discussionsupporting

confidence: 44%

Influence of Particle Size of Deproteinized Bovine Bone Mineral on New Bone Formation and Implant Stability after Simultaneous Sinus Floor Elevation: A Histomorphometric Study in Minipigs

Jensen

Aaboe

Janner

et al. 2013

Clinical Implant Dentistry and Related Research

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“…From there, the values decreased significantly with increasing distance from the local jawbone (ROI 6). The results are comparable to those described by Busenlechner et al [30] and Fuerst et al [31], who investigated the gradient of NBF in different osteoconductive bone substitute materials during sinus floor augmentations in a curve-based manner. After 12 weeks, the gradient of NBF differed from that after 1 month.…”

Section: Discussionsupporting

confidence: 89%

Influence of synthetic polyethylene glycol hydrogels on new bone formation during mandibular augmentation procedures in Goettingen minipigs

Brockmeyer

Kramer²,

Krohn

et al. 2015

J Mater Sci: Mater Med

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Polyethylene glycol hydrogels (PEG) have been used as slow release carrier for osteoinductive growth factors in order to achieve a retarded delivery. However, there have been concerns about negative effects on bone regeneration. This study aims to test whether PEG hydrogels themselves affect new bone formation (NBF), when used as a carrier during mandibular augmentation procedures. In a randomized split-mouth design, bilateral mandibular bone defects were surgically created in 12 Goettingen minipigs, and subsequently augmented, using PEG hydrogel on one side of the mandible. The contralateral sides, without PEG, served as controls. After 4 and 12 weeks, bone formation was evaluated in six animals each. A comparison of the data, using a three-way analysis of variance (ANOVA), revealed a significant effect of the healing time and the region of the graft on the distribution and enhancement of NBF (P < .0001, respectively). Although a 0.3% (95%-CI [-5.5; 4.8]) lower volume density of newly formed bone could be observed over all PEG hydrogel sections, in contrast to the contralateral controls, the analysis revealed no clinically significant effects of the PEG hydrogel treatment on the total level (P = 0.90), and the distribution of NBF (P = 0.54). In conclusion, PEG hydrogels do not affect NBF when used as a carrier for osteoinductive growth factors during mandibular augmentation procedures.

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“…The data presented are in line with the results of a preclinical study in 10 minipigs using the same pasteous nano-crystalline hydroxyapatite bone substitute [37] that investigated the “bridging distance” in 0 to 1 mm distance to the host bone, the “region of graft consolidation” in 2 to 3 mm distance, and the “region of ceasing bone formation” in 4 to 5 mm distance: after 12 weeks, the bone volume was 53.3%, 26.4%, and 5.8% and the bone substitute volume was 6.2%, 24.5%, and 41.2%, respectively, in the three defined regions. While comparison seems limited due to difference in study design, the percentage decrease in histologic bone volume (−47.5%) appears greater than the percentage decrease of radiographic bone density in the present investigation (−22.7%) due to the fact that pasteous bone substitute material presents with a certain amount of inherent radiographic density, even though no bone formation has occurred yet.…”

Section: Discussionsupporting

confidence: 85%

Graft Remodeling following Transcrestal Sinus Floor Elevation via the Gel-Pressure Technique (GPT) and Pasteous Nano-Crystalline Hydroxyapatite Bone Substitute

et al. 2015

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Bone grafting of the maxillary sinus is attempted to compensate for sinus pneumatization and permit reliable insertion of endosseous dental implants for prosthetic rehabilitation. The aim of the present clinical investigation was to study bone regeneration four months after transcrestal sinus floor elevation via the Gel-Pressure Technique (GPT) and application of pasteous nano-crystalline hydroxyapatite bone substitute. A total of 25 patients with deficient alveolar ridges in the posterior maxilla (mean residual bone height: 4.7 ± 1.8 mm) were subjected to 32 flapless transcrestal sinus floor augmentations and simultaneous insertion of 40 implants. Sinus membrane elevation height averaged 11.2 ± 2.7 mm and minimal vertical graft resorption of 0.1 mm was observed after four months. Radiographic bone density averaged 460 Hounsfield units in regions adjacent to the native jawbone (1 to 7 mm distance), while reduction of bone density by −7.2%, −11.3%, −14.8%, −19.6% and −22.7% was recorded in more apical regions of 8, 9, 10, 11, and ≥12 mm distance to the original sinus floor, respectively. The results suggest that graft remodeling is completed up to a distance of 7 mm within a healing period of four months after sinus augmentation using nano-crystalline hydroxyapatite bone substitute material.

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Sinus augmentation analysis revised: the gradient of graft consolidation

Abstract: Based on the graft consolidation gradient, the impact of bone substitutes to modulate the process of bone formation and the kinetic of degradation within a distinct region of the augmented sinus can be investigated.

Cited by 79 publications

References 24 publications

Influence of Particle Size of Deproteinized Bovine Bone Mineral on New Bone Formation and Implant Stability after Simultaneous Sinus Floor Elevation: A Histomorphometric Study in Minipigs

Influence of Particle Size of Deproteinized Bovine Bone Mineral on New Bone Formation and Implant Stability after Simultaneous Sinus Floor Elevation: A Histomorphometric Study in Minipigs

Influence of synthetic polyethylene glycol hydrogels on new bone formation during mandibular augmentation procedures in Goettingen minipigs

Graft Remodeling following Transcrestal Sinus Floor Elevation via the Gel-Pressure Technique (GPT) and Pasteous Nano-Crystalline Hydroxyapatite Bone Substitute

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