Sinus augmentation analysis revised: The gradient of graft consolidation

Maxillary sinus floor augmentation with Bio-Oss or Bio-Oss mixed with autogenous bone as graft in animals: a systematic review

“…No long-term animal study focusing on the biodegradation of Bio-Oss was identified. The available studies with an observation period up to 15 months indicated that Bio-Oss undergoes no, or limited, biodegradation after MSFA as well as in critical-size defects and domes 3,15,17,22,23,33,[38][39][40]47 . Biodegradation of Bio-Oss after MSFA with BioOss or Bio-Oss mixed with autogenous bone has never been compared in animals.…”

“…The Bio-Oss particles adjacent to the host bone were primarily surrounded by new bone, whilst Bio-Oss particles within the central part of the augmented region were mainly embedded in connective tissue 3,12,17,23,24,33,42 . When an equal proportion of Bio-Oss and autogenous iliac bone was used as graft, the proportion of newly formed bone was 52% after 6 weeks in minipigs 32 .…”

“…14 animal studies using the lateral window technique for the MSFA were identified 3,12,[15][16][17]20,23,24,[32][33][34]37,42,47 . The studies included revealed considerable variations in study design, so metaanalyses were not applicable.…”

“…In supplementary studies, the proportion of newly formed mineralized bone varied between 20% and 70% after 4-18 months when MSFA involved BioOss 17,23,24 , and bone regeneration seemed to increase during a 1-12-week healing period 3,12,37 . The proportion of newly formed bone declined substantially with increased distance from the host bone 3,12 .…”

“…The above-mentioned studies included histologic evaluation of the presence or absence of osteoclast-like cells at specific time-points 3,15,17,33,47 . No study included quantitation over time.…”