2018
DOI: 10.1111/jcpe.12921
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Sinus augmentation using rhBMP‐2/ACS in a mini‐pig model: Influence of an adjunctive ceramic bone biomaterial

Abstract: Whereas rhBMP-2/ACS supports significant bone formation/osseointegration in the mini-pig sinus augmentation model and thus appears an effective alternative for sinus augmentation procedures, adding a ceramic biomaterial to rhBMP-2/ACS does not produce meaningful biological advantages.

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Cited by 9 publications
(7 citation statements)
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“…14,15 These BIC (%) values were similar to those found in studies evaluating implant placement on rhBMP-2-induced bone. 22,23 In this study, the BIC (%) values of vertically augmented bone were not statistically different from those of native bone, based on the finding that there was no statistical BIC (%) difference between the microthreaded and macrothreaded regions. These observations indicate that successful osseointegration, which was sufficient to execute clinical functions, was obtained on bone that was vertically augmented with a PCL composite scaffold and rhBMP-2.…”
Section: Discussionmentioning
confidence: 56%
“…14,15 These BIC (%) values were similar to those found in studies evaluating implant placement on rhBMP-2-induced bone. 22,23 In this study, the BIC (%) values of vertically augmented bone were not statistically different from those of native bone, based on the finding that there was no statistical BIC (%) difference between the microthreaded and macrothreaded regions. These observations indicate that successful osseointegration, which was sufficient to execute clinical functions, was obtained on bone that was vertically augmented with a PCL composite scaffold and rhBMP-2.…”
Section: Discussionmentioning
confidence: 56%
“…The most commonly investigated growth factor is rhBMP‐2. rhBMP‐2 loaded onto collagen sponge and/or particulate bone substitute materials has been analysed extensively in this context (de Freitas et al, 2016; Lee et al, 2016; Susin et al, 2018; Visser et al, 2009). Other carriers such as bone‐block substitute materials have also been investigated, but they remain to be fully assessed.…”
Section: Discussionmentioning
confidence: 99%
“…In minipigs, comparable histometric outcomes were observed between dental implants placed in conjunction with sinus augmentation performed with rhBMP‐2/ACS or a particulate autogenous cancellous bone graft, although rhBMP‐2/ACS induced bone of superior density (Lee, Susin, Rodriguez, Stefano & Prasad, ). Furthermore, while adding BMP‐2 to TCP for 1‐stage sinus augmentation significantly increased BIC at 8 weeks (Ono, Sonoyama, Yamamoto, Oida & Akiyama, ), a recent study showed that the addition of a biphasic ceramic matrix to rhBMP‐2/ACS did not offer any advantage (Susin, Lee, Fiorini, Freitas & Chiu, ).…”
Section: Resultsmentioning
confidence: 99%