Sinus Bradycardia Rare but Expected Complications of Chemo Regimen Involving Dexamethasone: Case Report

Abstract

Weight gain, Osteoporosis, Glucose intolerance, Hypertension, and Cataract are the common complications associated with Dexamethasone. However, here we report a case of Multiple Myeloma who received chemotherapy involving Dexamethasone. Although this patient has no previous comorbid cardiac condition, he developed Sinus Bradycardia during the latter part of chemo regimen. Ironically Sinus Bradycardia was asymptomatic in these cases. The exact mechanism of how Dexamethasone causes Sinus Bradycardia is yet not properly understood, and some of the possible mechanisms of Dexamethasone causing Sinus Bradycardia have been postulated below.

Could Steroids Cause Dysrhythmia in COVID-19 Patients? A Case Report

“…Another hypothesis is that corticosteroids alter sodium and water physiology, increasing plasma volume and activating low-pressure baroreceptors [16]. Furthermore, bradycardia may occur as an idiosyncratic reaction to dexamethasone [18].…”