Sinus histiocytosis presenting as bilateral epibulbar masses

Atypical Ocular Presentations of Rosai-Dorfman Disease

“…6 The second case, by Ireland et al, is a 4-year-old child who presented with bilateral epibulbar masses without corneal involvement. 7 Early recognition of a relatively asymptomatic systemic disease in the eye is common given its sensitivity to minor changes in function and appearance compared to other organ systems.…”

Bilateral Epibulbar Xanthomas—A Case Report

“…16 Isolated epibulbar masses are a rare but recognized manifestation of extranodal Rosai-Dorfman disease. [6][7][8][9] Bilateral, multiple, subconjunctival nodules as an isolated finding in Rosai-Dorfman disease has been reported in a child and bilateral epibulbar masses have been reported as a presenting feature in an adult with Rosai-Dorfman disease and systemic involvement. 8,9 Epibulbar involvement has been described in disseminated Langerhans cell disease and an isolated limbal lesion in Langerhans cell disease has been reported in adult.…”

“…[6][7][8][9] Bilateral, multiple, subconjunctival nodules as an isolated finding in Rosai-Dorfman disease has been reported in a child and bilateral epibulbar masses have been reported as a presenting feature in an adult with Rosai-Dorfman disease and systemic involvement. 8,9 Epibulbar involvement has been described in disseminated Langerhans cell disease and an isolated limbal lesion in Langerhans cell disease has been reported in adult. 1,10,17 Necrobiotic xanthogranuloma, Rosai-Dorfman disease, and Langerhans cell disease have distinctive histopathological features, which include necrobiosis in necrobiotic xanthogranuloma, emperiopolesis (histiocytes displaying phagocytosed lymphocytes), and positive staining for S-100 protein in Rosai-Dorfman disease and CD1a staining in Langerhans cell disease.…”

“…Rarely, epibulbar involvement may occur as a presenting feature or as an isolated finding. [3][4][5][6][7][8][9][10] Epibulbar xanthomatous lesions are extremely rare, and to our knowledge, the occurrence of bilateral multiple lesions, in the absence of other features of a histiocytic disease, has not been reported previously.…”

Extranodal Rosai-Dorfman Disease Presenting as an Epibulbar Tumor

“…Since then, there have been only few scattered case reports. [8][9][10][11][12][13][14] Herein, we report a case of an epibulbar tumor as the only manifestation of RDD. A review of all previously published cases was also performed.…”