Siparuna guianensis Controls Toxoplasma gondii Infection In Vitro

Souza, Laura Vilela; Almeida, Marcos Paulo Oliveira; Silva, Neide M.; Miranda, Natália Carnevalli; Nebo, Liliane; Silva, Claudinei A. da; Moraes, Dayane; Rodrigues, Raphael Silva

doi:10.1007/s43450-021-00194-x

Cited by 1 publication

(1 citation statement)

References 33 publications

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“…The use of natural products with anti- Toxoplasma activity has received increasing attention. In vitro models, and in some cases, in vivo models, have been used for the evaluation of plant extracts, showing promising results [ 21 , 22 , 23 , 24 ].…”

Section: Discussionmentioning

confidence: 99%

In Vitro Anti-Toxoplasma Activity of Extracts Obtained from Tabebuia rosea and Tabebuia chrysantha: The Role of β-Amyrin

Cardona-Trujillo,

Jiménez-González,

Veloza

et al. 2024

Molecules

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Toxoplasmosis is a parasitic disease caused by the protozoan Toxoplasma gondii that is highly prevalent worldwide. Although the infection is asymptomatic in immunocompetent individuals, it severely affects immunocompromised individuals, causing conditions such as encephalitis, myocarditis, or pneumonitis. The limited therapeutic efficacy of drugs currently used to treat toxoplasmosis has prompted the search for new therapeutic alternatives. The aim of this study was to determine the anti-Toxoplasma activity of extracts obtained from two species of the genus Tabebuia. Twenty-six extracts, 12 obtained from Tabebuia chrysantha and 14 from Tabebuia rosea, were evaluated by a colorimetric technique using the RH strain of T. gondii that expresses β-galactosidase. Additionally, the activity of the promising extracts and their active compounds was evaluated by flow cytometry. β-amyrin was isolated from the chloroform extract obtained from the leaves of T. rosea and displayed important anti-Toxoplasma activity. The results show that natural products are an important source of new molecules with considerable biological and/or pharmacological activity.

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