Sirolimus-coated, poly(l-lactic acid)-modified polypropylene mesh with minimal intra-peritoneal adhesion formation in a rat model

Lu, Sheng; Hu, Wusheng; Zhang, Z.; Ji, Zhenling; Zhang, T.

doi:10.1007/s10029-018-1782-4

Cited by 12 publications

(5 citation statements)

References 25 publications

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“…Absorption time should be a maximum of 5 days in accordance with the pathophysiology of adhesion formation. [ 11 ] The Fx used in our study is 95% pure and does not leave any particles because it is completely dissolved in saline, and can be completely absorbed from the peritoneum.…”

Section: Discussionmentioning

confidence: 99%

Preventive Effect of Fucoxanthin Administration on Intraabdominal Adhesion: An Experimental Animal Study

Dalbaşı¹

2021

Ulus Travma Acil Cerrahi Derg

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BACKGROUND: The most common cause of intra-abdominal adhesion (IAA) is previous abdominal surgery and mortality. IAA can cause serious complications such as chronic abdominal pain, ileus, and infertility. Approximately 3% of all laparotomies are related to adhesions. IAA reduces the quality of life of the patient, causes morbidity, and increases health expenditures. In this study, we aimed to investigate the preventive effect of fucoxanthin (Fx) on IAA in the intra-abdominal surgical adhesion model that experimentally created in rats. METHODS: This study used 21 Sprague-Dawley rats divided into three groups. After anesthesia, the abdomen was opened, the cecum and right abdominal wall were damaged with a sterile toothbrush until petechiae bleeding was seen. No additional action was taken to the control group. In the sham group, 5 cc saline solution was released into the peritoneum before the abdomen was closed. In the Fx group, 35 mg/kg Fx was instilled intraperitoneally and the abdomen was closed. On the 21 st post-operative day, all subjects were anesthetized with standard anesthesia. Macroscopic adhesions were quantitatively evaluated according to the Mazuji classification. The cecum anterior wall and parietal peritoneum were excised for pathological sampling. A pathologist, unaware of the groups, evaluated inflammation, fibroblastic activity, and vascular proliferation. In addition, serum tumor necrosis factor-alpha (TNF-α) and interleukin-10 levels were measured. RESULTS: No rat was lost during the study period. Congenital adhesion was not observed in any of the subjects at the first laparotomy. Adhesion was significantly less macroscopically in the Fx group compared to the control and sham group (p<0.001 and p<0.001). Fibroblastic activity was found to be significantly less in the Fx group compared to the sham and control groups (p<0.001 and p<0.001). Vascular proliferation was found to be significantly less in the Fx group than in the sham and control groups (p<0.001 and p<0.001). The inflammation score was significantly lower in the Fx group compared to the other two groups (p<0.001 and p<0.001). The inflammation score in the sham group was lower than the control group and was statistically significant (p<0.001). TNF-α level was found to be statistically significantly lower in the Fx group compared to the sham and control groups (p<0.001 and p<0.001). CONCLUSION: As a result of experimental study, we can say that Fx is effective in preventing IAAs and decreases the level of TNF-α, a pro-inflammatory cytokine.

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Section: Discussionmentioning

confidence: 99%

Preventive Effect of Fucoxanthin Administration on Intraabdominal Adhesion: An Experimental Animal Study

Dalbaşı¹

2021

Ulus Travma Acil Cerrahi Derg

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“…Patient-friendly and functional prosthetic meshes can be designed by modifying various functional agents onto the surface of non-absorbable commercial meshes by biological, chemical, and physical treatments. Metallic ions or metal-based nanoparticles [ 201 , 202 ], hydrogels [ [203] , [204] , [205] ], fibrous membranes [ 206 , 188 ], drugs or bioactive agents [ 207 ], and cells or tissues [ 208 , 209 ] are the common coating options for the surface modification process. The most commonly reported surface modification approaches were displayed in Table 5 .…”

Section: Engineered Prosthetic Meshesmentioning

confidence: 99%

Abdominal wall hernia repair: from prosthetic meshes to smart materials

Saiding,

Chen,

Wang

et al. 2023

Materials Today Bio

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“…Therefore, the application of PP for hernia repair is limited. 4,5 Adhesions develop after nearly every abdominal surgery. Some reports cite that about 93% of patient who undergo abdominal surgery have abdominal adhesions.…”

Section: Introductionmentioning

confidence: 99%

“…For instance, polypropylene (PP) is one of the most commonly used prosthetic materials for repairing abdominal wall defects, but possibly serious abdominal adhesions can occur after mesh implantation, as well as some consequent complications, such as chronic pain, intestinal obstruction, and fistula. Therefore, the application of PP for hernia repair is limited. , …”

Section: Introductionmentioning

confidence: 99%

Combination of Polypropylene Mesh and in Situ Injectable Mussel-Inspired Hydrogel in Laparoscopic Hernia Repair for Preventing Post-Surgical Adhesions in the Piglet Model

Zhang

Long

et al. 2020

ACS Biomater. Sci. Eng.

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Polypropylene (PP) mesh has been used successfully for a long time in clinical practice as an impressive prosthesis for ventral hernia repair. To utilize a physical barrier for separating mesh from viscera is a general approach for preventing adhesions in clinical practice. However, a serious abdominal adhesion between the mesh and viscera can possibly occur post-hernia, especially with the small intestine; this can lead to a series of complications, such as chronic pain, intestinal obstruction, and fistula. Thus, determining how to prevent abdominal adhesions between the mesh and viscera is still an urgent clinical problem. In this study, a dopamine-functionalized polysaccharide derivative (oxidized-carboxymethylcellulose-g-dopamine, OCMC-DA) was synthesized; this was blended with carboxymethylchitosan (CMCS) to form a hydrogel (OCMC-DA/CMCS) in situ at the appropriate time. The physical and chemical properties of the hydrogel were characterized successfully, and its excellent biocompatibility was presented by the in vitro cell test. The combination of this hydrogel and PP mesh was used in laparoscopic surgery for repairing the abdominal wall defect, where the hydrogel could become fixed in situ on the PP mesh to form an anti-adhesion gel-mesh. The results showed that the gel-mesh could prevent abdominal adhesions effectively in the piglet model. Moreover, the histology and immunohistochemical staining proved that the gel-mesh could effectively alleviate the inflammation reaction and deposition of collagen around the mesh, and it did not disturb the integration between mesh and abdominal wall. Thus, the gel-mesh has superior tissue compatibility.

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Sirolimus-coated, poly(l-lactic acid)-modified polypropylene mesh with minimal intra-peritoneal adhesion formation in a rat model

Abstract: The SRL-coated composite mesh showed minimal formation of intra-abdominal adhesions in a rat model of abdominal wall defect repair.

Cited by 12 publications

References 25 publications

Preventive Effect of Fucoxanthin Administration on Intraabdominal Adhesion: An Experimental Animal Study

Preventive Effect of Fucoxanthin Administration on Intraabdominal Adhesion: An Experimental Animal Study

Abdominal wall hernia repair: from prosthetic meshes to smart materials

Combination of Polypropylene Mesh and in Situ Injectable Mussel-Inspired Hydrogel in Laparoscopic Hernia Repair for Preventing Post-Surgical Adhesions in the Piglet Model

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