Sirolimus versus cyclosporine in haploidentical stem cell transplantation with posttransplant cyclophosphamide and mycophenolate mofetil as graft‐versus‐host disease prophylaxis

Hernani, Rafael; Piñana, José Luís; Pérez, Ariadna; Quintero, Abdiel; Montoro, Juan; Hernández‐Boluda, Juan Carlos; Carretero, Carlos; Balaguer‐Roselló, Aitana; Guerreiro, Manuel; Lorenzo, Ignacio; Aguilar-Gallardo, Cristóbal; Giménez, Estela; Navarro, David; Sanz, Miguel Á.; Sanz, Jaime; Solano, Carlos

doi:10.1002/jha2.183

Cited by 6 publications

(1 citation statement)

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“…PTCy combined with calcineurin inhibitors, such as cyclosporine A (CsA) or tacrolimus, is a well-established GVHD prophylaxis in the setting of HHSCT [ 25 ]. In terms of GVHD prophylaxis patients with hematological malignancies undergoing haploidentical stem cell transplantation with PTCy and mycophenolate mofetil (MMF), combined with cyclosporine A has shown to be a sufficient strategy in terms of engraftment, GVHD incidence, and survival [ 26 ]. The most preferred regimen for GVHD prophylaxis used is CsA–cyclophosphamide–MMF which is similar with the literature.…”

Section: Discussionmentioning

confidence: 99%

A single-center experience of haploidentical stem cell transplantation in hematological malignancies

MALKAN¹,

GÖKER²,

DEMİROĞLU³

et al. 2023

Turkish Journal of Medical Sciences

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Background/aim Since well-designed prospective comparative trials are lacking, haploidentical hematopoietic stem cell transplantations approach should be based on the expertise of a particular center. In this study, we aimed to report the results and outcomes of patients who underwent haploidentical hematopoietic stem cell transplantation. Materials and methods Thirty-nine patients who underwent transplantation in our clinic between 2015 and 2022 were retrospectively analyzed. Primary end point of this study is to find out the survival rates of the patients. Results The overall survival of patients was 29.9 ± 4.9 months. The disease-free survival of the patients was 37.8 ± 5.7 months. The 3-year overall survival rate of the patients was %50 and the 3-year disease-free survival rate of the patients was %53. Nineteen patients were nonsurvivors among a total of 39 patients. Busulfan–fludarabine–thiotepa was the most frequently used conditioning regimen for transplantation. Busulfan–fludarabin–antithymocyte globulin regimen is the second preferred conditioning regimen. Cyclosporine–cyclophosphamide–mycophenolate mofetil was the most widely used graft-versus-host disease prophylaxis regimen. Sixteen patients had graft-versus-host disease, 28% of the patients had acute graft-versus-host disease, and 13% had chronic graft-versus-host disease. Gastrointestinal system consists of the most involved organs in graft-versus-host disease since 15% of the patients had gastrointestinal graft-versus-host disease. First-degree relatives (parent/child) were the most frequent donor source for haploidentical hematopoietic stem cell transplantation. Sepsis was the most frequent reason of death among transplant patients. Conclusion In our center, we prefer to use high dose posttransplantation cyclophosphamide after haploidentical hematopoietic stem cell transplantation for graft-versus-host disease prophylaxis. With this approach, our center’s overall survival and disease-free survival rates are comparable and compatible with the literature findings.

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Section: Discussionmentioning

confidence: 99%