SIRT1 activation by curcumin pretreatment attenuates mitochondrial oxidative damage induced by myocardial ischemia reperfusion injury

Yang, Yang; Duan, Weixun; Lin, Yi; Yi, Wei; Liang, Zhenxing; Yan, Jing; Wang, Ning; Deng, Chao; Zhang, Song; Li, Yue; Chen, Wensheng; Yu, Shikai; Yi, Dan; Jin, Zhenxiao

doi:10.1016/j.freeradbiomed.2013.07.007

Cited by 204 publications

(193 citation statements)

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“…These chemicals include a number of agents including resveratrol, 19) cilostazol, 41) paeonol, 43) statins, 21) hydrogen sulfide 23,44) and persimmon. 45) Yang et al 15) demonstrated that pretreatment with curcumin attenuated mitochondrial oxidative damage induced by myocardial ischemia reperfusion injury through activation of SIRT1. In addition, a recent study showed that curcumin blocked the neurotoxicity of amyloid-beta [25][26][27][28][29][30][31][32][33][34][35] in rat cortical neurons and activation of SIRT1.…”

Section: Discussionmentioning

confidence: 99%

“…13,14) Recently, several studies found that pretreatment with curcumin significantly improves SIRT1 activation and attenuates oxidative stress. 15,16) Besides, many polyphenols have been shown to activate SIRT1 directly or indirectly, decrease SIPS and therefore have therapeutic potential for age-related vascular diseases. [17][18][19][20] However, whether or not pretreatment with curcumin affects the activation of SIRT1 in H 2 O 2 -treated endothelial cells and attenuate cellular senescence is unclear.…”

mentioning

confidence: 99%

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Curcumin Attenuates Hydrogen Peroxide-Induced Premature Senescence <i>via</i> the Activation of SIRT1 in Human Umbilical Vein Endothelial Cells

Sun

et al. 2015

Biological & Pharmaceutical Bulletin

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Endothelial senescence has been proposed to be involved in endothelial dysfunction and atherogenesis. Curcumin, a natural phenol, possesses antioxidant and anti-inflammatory properties. However, the effect of curcumin on endothelial senescence is unclear. This study explores the effect of curcumin on hydrogen peroxide (H 2 O 2 )-induced endothelial premature senescence and the mechanisms involved. Human umbilical vein endothelial cells (HUVECs) were cultured, and premature senescence was induced with 100 µM H 2 O 2 . Results showed that pretreatment with curcumin significantly attenuated the H 2 O 2 -induced HUVECs' premature senescence, which was evidenced by a decreased percentage of senescence-associated β-galactosidase positive cells, improved cell division and decreased expression of senescence-associated protein p21 (all p<0.05). Pretreatment with curcumin decreased oxidative stress and apoptosis in H 2 O 2 -treated HUVECs. Treatment of HUVECs with H 2 O 2 also down-regulated the phosphorylation of endothelial nitric oxide synthase (eNOS), decreased the level of nitric oxide in the culture medium, and inhibited the protein expression and enzymatic activity of silent information regulator 1 (SIRT1), while pretreatment with curcumin partly reversed these effects (all p<0.05). Treatment with curcumin alone enhanced the enzymatic activity of SIRT1, but didn't affect cellular senescence, cell growth or apoptosis compared to the Control. The inhibition of SIRT1 using SIRT1 short interfering RNA (siRNA) could decrease the expression and phosphorylation of eNOS and abrogate the protective effect of curcumin on H 2 O 2 -induced premature senescence. These findings suggest that curcumin could attenuate oxidative stress-induced HUVECs' premature senescence via the activation of SIRT1.Key words curcumin; endothelial senescence; silent information regulator 1 (SIRT1); hydrogen peroxide Cellular senescence is defined as an irreversible state of growth arrest and accompanied by a specific set of phenotypic changes, gene expression and cell function.1) It has been realized that senescence is induced by a variety of insults, including those causing intracellular oxidative stress, such as hydrogen peroxide (H 2 O 2 ).2) This kind of cellular senescence is called the stress-induced premature senescence (SIPS). Endothelial senescence has been proposed to be involved in endothelial dysfunction and atherogenesis.3) Human studies showed that there were vascular cells exhibiting the morphological features of cellular senescence. [4][5][6] Silent information regulator 1 (SIRT1) is a member of the sirtuin family of proteins, which are homologs of the Sir2 gene in Saccharomyces (S.) cerevisiae. SIRT1 has been known as an oxidized form of nicotinamide adenine dinucleotide (NAD + )-dependent class III histone deacetylase (HDAC) and plays a key role in regulating cellular senescence, cell survival and metabolism through deacetylation of various histones and non-histone substrates.7,8) SIRT1 is highly expressed in the vasculature. A gro...

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Curcumin Attenuates Hydrogen Peroxide-Induced Premature Senescence <i>via</i> the Activation of SIRT1 in Human Umbilical Vein Endothelial Cells

Sun

et al. 2015

Biological & Pharmaceutical Bulletin

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“…Reperfusion injury occurs due to ischaemia followed by reintroduction of blood flow to a previously ischaemic tissue, causing additional myocardial damage and cardiac contractile dysfunction (Silambarasan et al, 2015). As oxidative stress is an important contributor to ischaemia/reperfusion (I/R) injury, antioxidants have been considered as a potential therapeutic option (Yang et al, 2013). Oral pre-treatment with SA significantly improved the percent rate-pressure product and percent coronary flow when compared to untreated I/R hearts.…”

Section: Protective Role In Cardiovascular Diseasementioning

confidence: 99%

Sinapinic and protocatechuic acids found in rapeseed: isolation, characterisation and potential benefits for human health as functional food ingredients

Quinn

Gray

Meaney³

et al. 2017

Irish Journal of Agricultural and Food Research

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Rapeseed is one of the world’s major oilseeds, and rapeseed oil is produced by pressing of the seeds. This process results in the production of a low-economic-value by-product, rapeseed meal, which is commonly used as animal feed. Rapeseed meal is rich in bioactive phenolic compounds, including sinapinic acid (SA) and protocatechuic acid (PCA). Isolation of these bioactive compounds from a by-product of rapeseed oil production is largely in agreement with the current concept of the circular economy and total utilisation of crop harvest using a biorefinery approach. In this review, current information concerning traditional and novel methods to isolate phenolic compounds – including SA and PCA – from rapeseed meal, along with in vitro and in vivo studies concerning the bioactivity of SA and PCA and their associated health effects, is collated. These health effects include anti-inflammatory, anti-cancer, anti-diabetes activities, along with histone deacetylase inhibition and protective cardiovascular, neurological and hepatic effects. The traditional extraction methods include use of solvents and/or enzymes. However, a need for simpler, more efficient methodologies has led to the development of novel extraction processes, including microwave-assisted, ultrasound-assisted, pulsed electric field and high-voltage electrical discharge extraction processes.

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“…Determination of myocardial apoptosis Myocardial apoptosis was analyzed by a TUNEL (terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling) assay using an in situ cell death detection kit, as described previously [33] . The apoptosis index was expressed as the number of apoptotic myocytes/the total number of myocytes counted ×100%.…”

Section: Acta Pharmacologica Sinicamentioning

confidence: 99%

2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside protects murine hearts against ischemia/reperfusion injury by activating Notch1/Hes1 signaling and attenuating endoplasmic reticulum stress

Zhang

Zhao

et al. 2017

Acta Pharmacol Sin

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SIRT1 activation by curcumin pretreatment attenuates mitochondrial oxidative damage induced by myocardial ischemia reperfusion injury

Cited by 204 publications

References 34 publications

Curcumin Attenuates Hydrogen Peroxide-Induced Premature Senescence <i>via</i> the Activation of SIRT1 in Human Umbilical Vein Endothelial Cells

Curcumin Attenuates Hydrogen Peroxide-Induced Premature Senescence <i>via</i> the Activation of SIRT1 in Human Umbilical Vein Endothelial Cells

Sinapinic and protocatechuic acids found in rapeseed: isolation, characterisation and potential benefits for human health as functional food ingredients

2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside protects murine hearts against ischemia/reperfusion injury by activating Notch1/Hes1 signaling and attenuating endoplasmic reticulum stress

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