Sirt1: An Increasingly Interesting Molecule with a Potential Role in Bone Metabolism and Osteoporosis
Yi Chen,
Hefang Xiao,
Zirui Liu
et al.
Abstract:Osteoporosis (OP) is a common metabolic bone disease characterized by low bone mass, decreased bone mineral density, and degradation of bone tissue microarchitecture. However, our understanding of the mechanisms of bone remodeling and factors affecting bone mass remains incomplete. Sirtuin1 (SIRT1) is a nicotinamide adenine dinucleotide-dependent deacetylase that regulates a variety of cellular metabolisms, including inflammation, tumorigenesis, and bone metabolism. Recent studies have emphasized the important… Show more
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