SIRT1 and energy metabolism

Li, Xiaoling

doi:10.1093/abbs/gms108

Cited by 297 publications

(243 citation statements)

References 142 publications

(174 reference statements)

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“…Based on previous research, the activation of SIRT1 results in functions that contribute to antiaging, anti-inflammatory, antidiabetes, and antiobesity [6,15]. Through the lookup results above, the compounds that could potentially act as a SIRT1 activator also have the same efficacy of being anti-inflammatory, anti-diabetes, and anti-aging.…”

Section: Resultsmentioning

confidence: 87%

“…Of the seven sirtuins owned by the genome of mammals, SIRT1 consists of orthologous proteins and protein SIRT2 deacetylase-dependent on NAD+ [5]. Some data indicate that sirtuin is a metabolic sensor that directly connects the cellular metabolic status (via NAD+) with the chromatin structure and the regulation of gene expression (via histones deacetylation, transcription factors, and transcription cofactor) [6]. SIRT1 has a vital role in metabolism, development, and reproduction, as well as influencing many biologically complex phenomena, such as aging and disease [7].…”

Section: Introductionmentioning

confidence: 99%

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Virtual Screening of Indonesian Herbal Database to Find Sirtuin 1 Activators Using the Docking Method

Aldisa

Azminah

Erlina

et al. 2017

Asian J Pharm Clin Res

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Objective: Chemical compounds in plants often have benefits and efficacy that can be useful for medicine. Biochemistry and biomedicine research aims to develop new drugs for degenerative human diseases such as cancer, cardiovascular diseases, and diabetes mellitus. Humans have a protein that is the key for metabolic sensors in a variety of metabolic pathways, Sirtuin 1 (SIRT1). Currently, only resveratrol, fisetin, and quercetin, which are compounds from natural ingredients, have been tested as activators of SIRT1 even though there are many chemical compounds in plants that could potentially be SIRT1 activators. Four crystal forms act as SIRT1 activators: 4ZZH, 4ZZI, 4ZZJ, and 5BTR. Methods:In this study, we employed the docking of new molecular compounds from an Indonesian herbal database as SIRT1 activators. Virtual screening was done using AutoDock Vina. AutoDock Vina was validated beforehand to obtain the best grid box; based on this research, the best grid box for AutoDock Vina is 60 × 60 × 60. Results:The top 10 ranked compounds were obtained for each crystal form and for the same compounds of the four crystal forms, which are alphacarotene, Cassiamin C, casuarinin, and lutein.

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Section: Resultsmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Virtual Screening of Indonesian Herbal Database to Find Sirtuin 1 Activators Using the Docking Method

Aldisa

Azminah

Erlina

et al. 2017

Asian J Pharm Clin Res

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“…The NAD-dependent protein deacetylase, Sirt-1, is also recognized as another regulator of energy metabolism [37,[40][41][42]. Sirt-1 has critically-important roles in regulating cellular metabolism and controlling responses to cellular stresses via the regulation of target proteins, and is closely involved in the pathophysiology of stressinduced degenerative diseases including OA [9,13,20,21].…”

Section: Discussionmentioning

confidence: 99%

The Nicotinamide Adenine Dinucleotide (NAD)-Dependent Deacetylase Sirtuin-1 Regulates Chondrocyte Energy Metabolism through the Modulation of Adenosine Monophosphate-Activated Protein Kinase (AMPK) in Osteoarthritis(OA)

Kobayashi¹,

Terauchi²,

Yui³

et al. 2017

J Arthritis

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To clarify how the osteoarthritis (OA)-induced catabolic factor interleukin (IL)-1β affects chondrocyte energy metabolism, and especially to define the downstream pathway linking nicotinamide adenine dinucleotide (NAD)-dependent deacetylase Sirtuin-1 (Sirt-1) to energy metabolism in OA chondrocytes. Human chondrocytes were isolated from articular cartilage samples of patients with OA. The level of energy metabolism of OA chondrocytes was evaluated by monitoring the activity of the energy metabolic sensor, adenosine monophosphate-activated protein kinase (AMPK) and the level of production of adenosine triphosphate (ATP) in chondrocytes in the presence or absence of t IL-1β (10 ng/mL). Effects of IL-1β on anabolic and catabolic activities of chondrocytes were analyzed by the levels of production of proteoglycan and matrix metalloproteinase (MMP)-13, respectively. Experiments involving pre-treatment with Sirt-1 inhibitor were also performed to investigate the underlying regulatory mechanism linking Sirt-1 to chondrocyte energy metabolism. IL-1β significantly inhibited the activity of AMPK and production of ATP in OA chondrocytes. The energy metabolism disruption mediated by IL-1β was further decreased by pretreatment with Sirt-1 inhibitor in OA chondrocytes. Treatment with IL-1β significantly decreased the level of proteoglycan production and significantly increased the level of MMP-13 secretion by chondrocytes. These chondrocyte activities were also reduced by pre-treatment with the Sirt-1 inhibitor in OA chondrocytes. IL-1β inhibits the AMPK -ATP energy metabolic pathway in OA chondrocytes. Our findings also suggest that Sirt-1 activity is involved in anabolic and catabolic cellular activities and that Sirt-1 modulates ATP production through functional regulation of the energy sensor AMPK in chondrocytes.

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“…Therefore, mice starvation induced SIRT1 to bind the aP2 promoter in white adipose tissue (WAT), thereby down regulate gene expression, and accelerate mobilization of fat into the blood. This explain the association between decreasing fat storage and increasing lipolysis with up regulation of SIRT1 in differentiated adipose cells (Li, 2013). Moreover, treatment of mice on a high fat diet with resveratrol that is an activator of SIRT1 was shown to reduce weight gain.…”

Section: Modifying Sirt1 Gene Expressionmentioning

confidence: 94%

Effect of Ergonomic Exercises in Modifying Sirtuin1 Gene Expression in Obese Down Syndrome Patients

Zeidan¹,

Ahmed²,

Hashish³

et al. 2017

J App Pharm Sci

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The current study was conducted to investigate the effect of ergonomic exercises on modifying SIRT1 gene expression in obese Down syndrome patients. Forty obese Down syndrome patients (IQ level ˃ 60) were included in current study. Their age were ranged from 14 to 18 years old, their body mass index (BMI) was ranged from 30kg/m 2 to 39.9 kg/ m 2 , These patients were divided randomly and equally into two groups GI composed of twenty obese patients with down syndrome. They were received indoor ergonomic exercises two times / week for 3 months plus balanced diet and GII composed of twenty obese patients with Down syndrome. They were received balanced diet only. Data were obtained from each patient for BMI and SIRT1 level. Measurements were performed before study and after three months. Statistical analysis revealed that there was reduction of BMI within both groups after treatment in comparison to pre-treatment (p>0.05). Ergonomic exercises with balanced diet has a significant effect in reduction BMI and waist circumference (p; 0.0001* & 0.019*, respectively). Fold change as indicator for SIRT1 gene expression was changed in GII and GI respectively (40%, 27.27%). These results indicated that BMI and waist circumference reduced with exercises which may be an effective tool in modifying gene expression in Down syndrome obese patients.

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SIRT1 and energy metabolism

Cited by 297 publications

References 142 publications

Virtual Screening of Indonesian Herbal Database to Find Sirtuin 1 Activators Using the Docking Method

Virtual Screening of Indonesian Herbal Database to Find Sirtuin 1 Activators Using the Docking Method

The Nicotinamide Adenine Dinucleotide (NAD)-Dependent Deacetylase Sirtuin-1 Regulates Chondrocyte Energy Metabolism through the Modulation of Adenosine Monophosphate-Activated Protein Kinase (AMPK) in Osteoarthritis(OA)

Effect of Ergonomic Exercises in Modifying Sirtuin1 Gene Expression in Obese Down Syndrome Patients

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