SIRT1 downregulation provokes immune-inflammatory responses in hair follicle outer root sheath cells and may contribute to development of alopecia areata

Líu, Hao; Nam, Kyung-Hwa; Lee, Geon-Jong; Kim, Doyeon; Shin, Jung-Hye; Lee, Young; Kim, Chang Deok; Kim, Seong‐Jin; Yun, Seok Kweon; Park, Byung‐Hyun; Park, Jin

doi:10.1016/j.jdermsci.2023.05.005

Cited by 6 publications

(3 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For instance, the administration of VPA has been shown to inhibit the activity of HDAC, modulate macrophage polarization, increase the expression of anti-inflammatory cytokines, and enhance the immune response against inflammation in patients with SLE ( 149 ). In a separate study, the inhibition of SIRT1 was found to stimulate the secretion of Th1 cytokines, IFN-inducible chemokines, and T cell migration in ORS cells, thereby contributing to the development of AA ( 129 ). The significance of epithelial cells in the regulation of immunity has gained increasing recognition ( 167 ).…”

Section: Discussion and Expectationsmentioning

confidence: 99%

“…The antagonistic impact of SIRT1 on the immune response was mediated via the deacetylation of NF-κB and the phosphorylation of STAT3. Thus, SIRT1 downregulation may contribute to AA development ( 129 ). The variation of histone acetylation is observed in AA patients, which provides new ideas for the treatment of AA.…”

Section: Histone Modifications In Inflammatory Skin Diseasesmentioning

confidence: 99%

See 1 more Smart Citation

Noval advance of histone modification in inflammatory skin diseases and related treatment methods

Zhang,

Chai,

Tai

et al. 2024

Front. Immunol.

View full text Add to dashboard Cite

Inflammatory skin diseases are a group of diseases caused by the disruption of skin tissue due to immune system disorders. Histone modification plays a pivotal role in the pathogenesis and treatment of chronic inflammatory skin diseases, encompassing a wide range of conditions, including psoriasis, atopic dermatitis, lupus, systemic sclerosis, contact dermatitis, lichen planus, and alopecia areata. Analyzing histone modification as a significant epigenetic regulatory approach holds great promise for advancing our understanding and managing these complex disorders. Additionally, therapeutic interventions targeting histone modifications have emerged as promising strategies for effectively managing inflammatory skin disorders. This comprehensive review provides an overview of the diverse types of histone modification. We discuss the intricate association between histone modification and prevalent chronic inflammatory skin diseases. We also review current and potential therapeutic approaches that revolve around modulating histone modifications. Finally, we investigated the prospects of research on histone modifications in the context of chronic inflammatory skin diseases, paving the way for innovative therapeutic interventions and improved patient outcomes.

show abstract

Section: Discussion and Expectationsmentioning

confidence: 99%

Section: Histone Modifications In Inflammatory Skin Diseasesmentioning

confidence: 99%

Noval advance of histone modification in inflammatory skin diseases and related treatment methods

Zhang,

Chai,

Tai

et al. 2024

Front. Immunol.

View full text Add to dashboard Cite

show abstract

“…Lamin B1, Sirtuin-1, and Aging-Associated DNA Damage Given the complex, multi-level pathobiology of human skin aging (see Section 1), we next assessed whether melatonin non-discriminatively improves additional core skin-aging associated biomarkers across the board. To this end, we examined p16 INK4 protein expression, a key biomarker for senescent cells [28,32,60,77]; lamin B1, a nuclear lamina component whose abundance declines with age/senescence [36,78,79]; sirtuin-1 (SIRT-1), an NAD +dependent deacetylase enzyme that is crucially involved in cell and tissue aging [80][81][82][83]; and γH2A.x formation resulting from histone H2A.x phosphorylation as a marker of DNA damage [24,61,84,85].…”

Section: Melatonin Unfolds Differential Anti-aging Activities In Huma...mentioning

confidence: 99%

Melatonin Exerts Prominent, Differential Epidermal and Dermal Anti-Aging Properties in Aged Human Eyelid Skin Ex Vivo

Samra,

Gomez-Gomez,

Linowiecka

et al. 2023

IJMS

View full text Add to dashboard Cite

Human skin aging is associated with functional deterioration on multiple levels of physiology, necessitating the development of effective skin senotherapeutics. The well-tolerated neurohormone melatonin unfolds anti-aging properties in vitro and in vivo, but it remains unclear whether these effects translate to aged human skin ex vivo. We tested this in organ-cultured, full-thickness human eyelid skin (5–6 donors; 49–77 years) by adding melatonin to the culture medium, followed by the assessment of core aging biomarkers via quantitative immunohistochemistry. Over 6 days, 200 µM melatonin significantly downregulated the intraepidermal activity of the aging-promoting mTORC1 pathway (as visualized by reduced S6 phosphorylation) and MMP-1 protein expression in the epidermis compared to vehicle-treated control skin. Conversely, the transmembrane collagen 17A1, a key stem cell niche matrix molecule that declines with aging, and mitochondrial markers (e.g., TFAM, MTCO-1, and VDAC/porin) were significantly upregulated. Interestingly, 100 µM melatonin also significantly increased the epidermal expression of VEGF-A protein, which is required and sufficient for inducing human skin rejuvenation. In aged human dermis, melatonin significantly increased fibrillin-1 protein expression and improved fibrillin structural organization, indicating an improved collagen and elastic fiber network. In contrast, other key aging biomarkers (SIRT-1, lamin-B1, p16INK4, collagen I) remained unchanged. This ex vivo study provides proof of principle that melatonin indeed exerts long-suspected but never conclusively demonstrated and surprisingly differential anti-aging effects in aged human epidermis and dermis.

show abstract

Strategic Developments for Pre-clinical Safety/Efficacy Studies of Hair Care Products

Srivastava,

Pant

2024

Hair Care Products

View full text Add to dashboard Cite

SIRT1 downregulation provokes immune-inflammatory responses in hair follicle outer root sheath cells and may contribute to development of alopecia areata

Cited by 6 publications

References 34 publications

Noval advance of histone modification in inflammatory skin diseases and related treatment methods

Noval advance of histone modification in inflammatory skin diseases and related treatment methods

Melatonin Exerts Prominent, Differential Epidermal and Dermal Anti-Aging Properties in Aged Human Eyelid Skin Ex Vivo

Strategic Developments for Pre-clinical Safety/Efficacy Studies of Hair Care Products

Contact Info

Product

Resources

About