2017
DOI: 10.1002/tox.22499
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SIRT1 exhibits antioxidative effects in HT22 cells induced by tert‐butyl alcohol

Abstract: Tertiary butyl alcohol (TBA) is a principal metabolite of methyl tertiary-butyl ether (MTBE), a common pollutant worldwide in the ground or underground water, which is found to produce nervous system damage. Nevertheless, few data regarding the effects of TBA has been reported. Studies indicated that oxidative stress plays a pivotal role in MTBE neurotoxic mechanism. Sirtuin 1 (SIRT1) has been reported to exert a neuroprotective effect on various neurologic diseases via resistance to oxidative stress by deacet… Show more

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Cited by 6 publications
(2 citation statements)
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“…We have interpreted that atorvastatin shows its neuroprotective effect via SIRT1 induction as well. The decreased expression of protective SIRT1 was also observed in various neurotoxicity models of AD in mouse hippocampal nerve cells (HT‐22), SH‐SY5Y cells and endogenously Aβ overproducing N2aSwe cells as well as the decreased expression of autophagy proteins such as beclin‐1, Atg5, LC3II . SIRT1 provides the processing of APP in the AD by controlling Aβ metabolism, and the production of Aβ in the absence of SIRT1 increases excessively .…”
Section: Discussionmentioning
confidence: 88%
“…We have interpreted that atorvastatin shows its neuroprotective effect via SIRT1 induction as well. The decreased expression of protective SIRT1 was also observed in various neurotoxicity models of AD in mouse hippocampal nerve cells (HT‐22), SH‐SY5Y cells and endogenously Aβ overproducing N2aSwe cells as well as the decreased expression of autophagy proteins such as beclin‐1, Atg5, LC3II . SIRT1 provides the processing of APP in the AD by controlling Aβ metabolism, and the production of Aβ in the absence of SIRT1 increases excessively .…”
Section: Discussionmentioning
confidence: 88%
“…Increased oxidative stress is likely to come from AA, the metabolite of ETBE, which is a well‐known inducer of oxidative stress (Seitz & Stickel, ; Zhang, Li, Brown, & Ren, ). However, TBA's toxic role cannot be ignored because TBA may also induce oxidative stress (Ma et al, ).…”
Section: Introductionmentioning
confidence: 99%