SIRT1 gene variants are related to risk of childhood obesity

Kılıç, Ülkan; Gök, Özlem; Elibol-Can, Birsen; Özgen, İlker Tolga; Erenberk, Ufuk; Uysal, Ömer; Dündaröz, Mehmet Ruşen

doi:10.1007/s00431-014-2424-1

Cited by 18 publications

(17 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…SIRT1 impacts many areas of biology and pathophysiology, including cancer, metabolism, circadian rhythm, neurodegeneration, inflammation, and cardiovascular disease (18). Furthermore, Sirt1 variants are associated with familial diabetes and childhood obesity (19, 20). In addition, SIRT1 influences immune function in diverse ways by regulating processes such as lymphocyte activation, T-cell proliferation and differentiation, and macrophage secretion (21).…”

Section: Introductionmentioning

confidence: 99%

Sirtuin 1 Regulates Dendritic Cell Activation and Autophagy during Respiratory Syncytial Virus–Induced Immune Responses

Owczarczyk

Schaller

Reed

et al. 2015

The Journal of Immunology

View full text Add to dashboard Cite

Respiratory syncytial virus (RSV) is the major cause of lower respiratory tract infection in children worldwide. Sirtuin 1 (SIRT1), an NAD+ dependent deacetylase, has been associated with the induction of autophagy and the regulation of inflammatory mediators. We found that Sirt1 was upregulated in mouse lung after RSV infection. Infected animals that received EX-527, a selective SIRT1 inhibitor, displayed exacerbated lung pathology, with increased mucus production, elevated viral load, and enhanced Th2 cytokine production. Gene expression analysis of isolated cell populations revealed that Sirt1 was most highly upregulated in RSV-treated dendritic cells (DCs). Upon RSV infection, EX-527-treated DCs, Sirt1 siRNA-treated DCs, or DCs from conditional knockout (Sirt1f/f-CD11c–Cre+) mice showed downregulated inflammatory cytokine gene expression and attenuated autophagy. Finally, RSV infection of Sirt1f/f-CD11c–Cre+ mice resulted in altered lung and lymph node cytokine responses, leading to exacerbated pathology. These data indicate that SIRT1 promotes DC activation associated with autophagy-mediated processes during RSV infection, thereby directing efficient antiviral immune responses.

show abstract

Section: Introductionmentioning

confidence: 99%

Sirtuin 1 Regulates Dendritic Cell Activation and Autophagy during Respiratory Syncytial Virus–Induced Immune Responses

Owczarczyk

Schaller

Reed

et al. 2015

The Journal of Immunology

View full text Add to dashboard Cite

show abstract

“…Therefore, with regard to the parameter of rs7895833, it is plausible to suggest that Caucasians are more vulnerable to obesity risks than are Asians. However, in Turkish children, the risk of obesity was increased 1.9 times in carriers of the G allele of rs7895833, whereas the A allele was suggested to be protective against obesity [22]. Since there was no GG homozygote in the Turkish population, a comparison between the Turkish and the global population would require further research.…”

Section: Discussionmentioning

confidence: 99%

The Gender Association of the SIRT1 rs7895833 Polymorphism with Pediatric Obesity: A 3-Year Panel Study

Lee

Choi²,

Lee³

et al. 2016

Lifestyle Genomics

View full text Add to dashboard Cite

Objectives: Sirtuin 1 (SIRT1), a longevity-associated gene, has pleiotropic functions. We investigated whether SIRT1 variation is associated with pediatric obesity. Methods: During 3 years of follow-up of 219 children (101 boys, 118 girls) aged 8 or 9 years at baseline, obesity parameters such as anthropometrics, plasma lipid and insulin resistance profiles, and nutrient intakes were analyzed with regard to 3 genotypes of SIRT1 rs7895833 (GG, GA, and AA). Results: The prevalence of obesity including overweight had increased from 18.3% (in 2007) to 25.1% (in 2010), and the incidence of obesity over 3 years from nonobesity at the baseline was 11.7%. In the obesity group (BMI >85th percentile) that had been nonobese 3 years before, the frequency of the GA+AA genotypes was higher than that of the GG genotype. Among the total number of subjects, the values for criteria for obesity such as BMI and waist circumference were higher in the GA+AA group than in the GG group. In boys, the reductions in total cholesterol and low-density lipoprotein cholesterol levels in the GG group were considerably greater than those in the GA+AA group, even though the changes in carbohydrate, fat, and protein intake in the GG group were higher than in the GA+AA group. In girls, the reductions in fasting blood sugar and homeostatic model assessment insulin resistance (HOMA-IR) levels were greater in the GA+AA group than in the GG group, despite unchanged energy intakes over 3 years. Conclusions: We identified an association between SIRT1 variation and pediatric obesity in Korean children with a gender difference.

show abstract

“…(v) Plasma Total antioxidant capacity (TAC) levelsby colorimetric method using commercial kits (Biodiagnostics) (Koracevic et al, 2001). (vi) Genotyping of the SIRT 1(rs7069102) gene polymorphism by PCR-CTPP technique according to Atsuta and Hamajima (2003) and Kilic et al (2015). Briefly, Genomic DNA was extracted from 200 μl of EDTA-anticoagulated blood using the Qiagen mini blood DNA purification kits (Qiagen, Canada) according to the manufacturer's instructions.…”

Section: Laboratory Investigations Includedmentioning

confidence: 99%

New insight on premature atherosclerosis in Egyptian children with -thalassemia major

Ibrahim¹,

Zakaria²,

El-Batch³

et al. 2018

Afr. J. Biochem. Res.

View full text Add to dashboard Cite

Beta-thalassemia major (β-TM) in children is associated with an increase in the risk of premature cardiovascular complications caused by accelerated atherosclerosis which significantly contributes to morbidity and mortality. The molecular mechanisms underlying β-TM associated atherosclerosis and its relation to biochemical risk factors still remain obscure. We aimed to investigate the association between SIRT1 single nucleotide polymorphism (SNP), lipid profile, ferritin, malondialdehyde (MDA), 8hydroxydeoxy guanosine (8-OHdG) and total antioxidant capacity (TAC) in relation to carotid intima media thickness (CIMT) trying to explain some mechanisms of cardiovascular complication in beta-Thalassemia major (β-TM) children. This study was carried out on 100 Egyptian children with β-TM (Group II) subdivided equally according to CIMT into Group IIa, with CIMT<0.5 mm and Group IIb with CIMT ≥ 0.5 mm, in addition to 50 healthy children as controls (Group I). All groups were subjected to measurement of plasma Ferritin, lipid profile, MDA and TAC colorimetrically. 8-OHdG levels were estimated by enzyme-linked immunosorbent assay (ELISA) in addition genotyping pattern for the SIRT1 (rs7069102) SNP was evaluated using PCR-CTPP technique. Values for AIP, ferritin, MDA and 8-OHdG levels, were significantly higher in β-TM groups compared to control with higher levels in patients with CIMT more than 0.5 mm but values of TAC and (HDL-C) showed significant decrease. CIMT was significantly correlated with age, atherogenic index of plasma (AIP), ferritin, MDA and 8-OHdG, HDL-C and TAC. There was significant difference in C allele distribution of SIRT1 rs7096102 was 57% in control subjects, 29% in Group IIa and 23% in Group IIb. However, the allele G distribution was 43% in control subjects, 71% in Group IIa and 77% Group IIb. Significant association of SIRT1 (rs7069102) polymorphism with dyslipidemia, ferritin and oxidative stress may conduct atherosclerotic potential in β-TM by affecting the severity of CIMT.

show abstract

SIRT1 gene variants are related to risk of childhood obesity

Abstract: This is the first study reporting an association between SIRT1 gene polymorphisms and obesity in children.

Cited by 18 publications

References 38 publications

Sirtuin 1 Regulates Dendritic Cell Activation and Autophagy during Respiratory Syncytial Virus–Induced Immune Responses

Sirtuin 1 Regulates Dendritic Cell Activation and Autophagy during Respiratory Syncytial Virus–Induced Immune Responses

The Gender Association of the SIRT1 rs7895833 Polymorphism with Pediatric Obesity: A 3-Year Panel Study

New insight on premature atherosclerosis in Egyptian children with -thalassemia major

Contact Info

Product

Resources

About