SIRT1 regulated hexokinase-2 promoting glycolysis is involved in hydroquinone-enhanced malignant progression in human lymphoblastoid TK6 cells

Chen, Yuting; Yang, Hui; Chen, Shaoyun; Lu, Zhaohong; Li, Boxin; Jiang, Tikeng; Xuan, Mei; Ye, Ruifang; Liang, Heng; Liu, Xiaoshan; Liu, Qizhan; Tang, Huanwen

doi:10.1016/j.ecoenv.2022.113757

Cited by 10 publications

(7 citation statements)

References 41 publications

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“…Accumulating evidence reveals that cMyc promotes glycolysis and oxidative phosphorylation in several cancers [ 47 ]. In addition, Chen and his colleagues reported that SIRT1 promotes hexokinase-2 (HK-2) as a strong oncogenic driver to enhance glycolysis and tumorigenesis [ 48 ]. Furthermore, Wnt/β-catenin signaling can promote cancer cell glycolysis in association with c-Myc [ 49 , 50 ].…”

Section: Discussionmentioning

confidence: 99%

The Apoptotic and Anti-Warburg Effects of Brassinin in PC-3 Cells via Reactive Oxygen Species Production and the Inhibition of the c-Myc, SIRT1, and β-Catenin Signaling Axis

Kwon,

Ahn,

Lee

et al. 2023

IJMS

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Though Brassinin is known to have antiangiogenic, anti-inflammatory, and antitumor effects in colon, prostate, breast, lung, and liver cancers, the underlying antitumor mechanism of Brassinin is not fully understood so far. Hence, in the current study, the apoptotic mechanism of Brassinin was explored in prostate cancer. Herein, Brassinin significantly increased the cytotoxicity and reduced the expressions of pro-Poly ADP-ribose polymerase (PARP), pro-caspase 3, and B-cell lymphoma 2 (Bcl-2) in PC-3 cells compared to DU145 and LNCaP cells. Consistently, Brassinin reduced the number of colonies and increased the sub-G1 population and terminal deoxynucleotidyl transferase (TdT) dUTP Nick-End Labeling (TUNEL)-positive cells in the PC-3 cells. Of note, Brassinin suppressed the expressions of pyruvate kinase-M2 (PKM2), glucose transporter 1 (GLUT1), hexokinase 2 (HK2), and lactate dehydrogenase (LDH) as glycolytic proteins in the PC-3 cells. Furthermore, Brassinin significantly reduced the expressions of SIRT1, c-Myc, and β-catenin in the PC-3 cells and also disrupted the binding of SIRT1 with β-catenin, along with a protein–protein interaction (PPI) score of 0.879 and spearman’s correlation coefficient of 0.47 being observed between SIRT1 and β-catenin. Of note, Brassinin significantly increased the reactive oxygen species (ROS) generation in the PC-3 cells. Conversely, ROS scavenger NAC reversed the ability of Brassinin to attenuate pro-PARP, pro-Caspase3, SIRT1, and β-catenin in the PC-3 cells. Taken together, these findings support evidence that Brassinin induces apoptosis via the ROS-mediated inhibition of SIRT1, c-Myc, β-catenin, and glycolysis proteins as a potent anticancer candidate.

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Section: Discussionmentioning

confidence: 99%

The Apoptotic and Anti-Warburg Effects of Brassinin in PC-3 Cells via Reactive Oxygen Species Production and the Inhibition of the c-Myc, SIRT1, and β-Catenin Signaling Axis

Kwon,

Ahn,

Lee

et al. 2023

IJMS

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“…As previously reported, the energy source of some glioma stem cells (GSCs) primarily depends on glycolysis [ 64 , 65 , 66 ]. In addition, the activation of some glycolytic enzymes, rather than oncogenes, can cause tumourigenesis and transformation, providing favourable evidence for the metabolic influence on tumorigenesis [ 67 , 68 , 69 ]. Notably, the biological and biochemical processes of some transcription factors, such as Myc proto-oncogene protein (c-Myc) and Nuclear factor NF-kappa-B (NF-κB), are mainly dependent on glycolytic reactions [ 9 , 70 , 71 , 72 ].…”

Section: Metabolic Plasticity In the Initiation Of Tumourigenesismentioning

confidence: 99%

Regulative Roles of Metabolic Plasticity Caused by Mitochondrial Oxidative Phosphorylation and Glycolysis on the Initiation and Progression of Tumorigenesis

Niu

et al. 2023

IJMS

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One important feature of tumour development is the regulatory role of metabolic plasticity in maintaining the balance of mitochondrial oxidative phosphorylation and glycolysis in cancer cells. In recent years, the transition and/or function of metabolic phenotypes between mitochondrial oxidative phosphorylation and glycolysis in tumour cells have been extensively studied. In this review, we aimed to elucidate the characteristics of metabolic plasticity (emphasizing their effects, such as immune escape, angiogenesis migration, invasiveness, heterogeneity, adhesion, and phenotypic properties of cancers, among others) on tumour progression, including the initiation and progression phases. Thus, this article provides an overall understanding of the influence of abnormal metabolic remodeling on malignant proliferation and pathophysiological changes in carcinoma.

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“…HK-2, the rate-limiting enzyme in the first stage of glycolysis, is essential for converting glucose to glucose-6-phosphate [ 78 ]. Overexpression of HK-2 frequently occurs in various tumors, resulting in enhanced glucose metabolism, resistance to cell apoptosis, and tumor-invading capacity.…”

Section: Discussionmentioning

confidence: 99%

Association between glycolysis markers and prognosis of liver cancer: a systematic review and meta-analysis

Wang,

2023

World J Surg Onc

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Background In recent years, the capacity of tumor cells to maintain high levels of glycolysis, even in the presence of oxygen, has emerged as one of the main metabolic traits and garnered considerable attention. The purpose of this meta-analysis is to investigate the prognostic value of glycolysis markers in liver cancer. Methods PubMed, Embase, and Cochrane Library databases were searched for articles on glycolytic marker expression levels associated with the prognosis of liver cancer until April 2023. Stata SE14.0 was used to calculate the aggregate hazard ratios and 95% confidence intervals. Results Thirty-five studies were included. The worse overall survival (OS) (P < 0.001), disease-free survival (DFS) (P = 0.001), recurrence-free survival (RFS) (P = 0.004), and time to recurrence (TTR) (P < 0.001) were significantly associated with elevated expression of glycolysis markers. Higher expression of PKM2 (P < 0.001), STMN1 (P = 0.002), MCT4 (P < 0.001), GLUT1 (P = 0.025), HK-2 (P < 0.001), and CA9 (P < 0.001) were significantly related to shorter OS. Increased levels of PKM2 (P < 0.001), CA9 (P = 0.005), and MCT4 (P < 0.001) were associated with worse DFS. Elevated PKM2 expression (P = 0.002) was also associated with poorer RFS in hepatocellular carcinoma patients. GLUT2 expression was not correlated with the prognosis of liver cancer (P = 0.134). Conclusions Elevated expression of glycolysis markers was associated with worse OS, DFS, RFS, and TTR in patients with liver cancer. Therefore, these glycolysis markers could serve as potential prognostic markers and therapeutic targets in liver cancer. Trial registration PROSPERO registration: CRD42023469645.

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SIRT1 regulated hexokinase-2 promoting glycolysis is involved in hydroquinone-enhanced malignant progression in human lymphoblastoid TK6 cells

Cited by 10 publications

References 41 publications

The Apoptotic and Anti-Warburg Effects of Brassinin in PC-3 Cells via Reactive Oxygen Species Production and the Inhibition of the c-Myc, SIRT1, and β-Catenin Signaling Axis

The Apoptotic and Anti-Warburg Effects of Brassinin in PC-3 Cells via Reactive Oxygen Species Production and the Inhibition of the c-Myc, SIRT1, and β-Catenin Signaling Axis

Regulative Roles of Metabolic Plasticity Caused by Mitochondrial Oxidative Phosphorylation and Glycolysis on the Initiation and Progression of Tumorigenesis

Association between glycolysis markers and prognosis of liver cancer: a systematic review and meta-analysis

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