SIRT1: Role in cardiovascular biology

Ma, Lina; Li, Yun

doi:10.1016/j.cca.2014.10.036

Cited by 52 publications

(32 citation statements)

References 133 publications

(167 reference statements)

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“…Short-term CR can improve insulin sensitivity and reduce the risk of cardiovascular diseases, indicating its potential benefit for human health. Silent mating-type information regulation 1 (SIRT1) agonist-resveratrol has protective effects on cardiovascular function, lipid lowering, increased glucose tolerance, and insulin sensitivity (7). These effects mimic the Popular scientific summary • CR activates the SIRT1/AMPK pathway in mice myocardium.…”

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confidence: 76%

“…CR is capable of improving the cardiovascular risk factors such as glycolipid metabolism and insulin resistance, but the mechanism of cardiovascular protection remains unclear. SIRT1 is known to reduce inflammation, possess anti-atherosclerosis activity, inhibit cardiomyocyte apoptosis and telomere shortening, resist myocardial oxidative stress damage and myocardial remodeling, maintain myocardial energy balance, and promote autophagy (7). AMPK can inhibit cell proliferation by affecting the cell cycle and metabolism when myocardial and vascular smooth muscle cells are stimulated by ischemia/hypoxia or cardiovascular active substances, playing an important role in the cardiovascular system (10,11).…”

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confidence: 99%

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Long-term caloric restriction activates the myocardial SIRT1/AMPK/PGC-1α pathway in C57BL/6J male mice

Wang

Wang³

et al. 2020

Food & Nutrition Research

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confidence: 76%

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confidence: 99%

Long-term caloric restriction activates the myocardial SIRT1/AMPK/PGC-1α pathway in C57BL/6J male mice

Wang

Wang³

et al. 2020

Food & Nutrition Research

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“…SIRT1 serves as an anti-atherosclerotic factor by mediating endothelial nitric oxide synthase (eNOS) and improving endothelial dysfunction, regulating inflammation, reversing cholesterol transport and reducing the risk of CAD. 14…”

Section: Discussionmentioning

confidence: 99%

Sirtuin 1 rs1467568 and rs7895833 in South African Indians with early-onset coronary artery disease

Ramkaran¹,

Phulukdaree²,

Khan³

et al. 2016

CVJA

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SummaryBackgroundSirtuin 1 (SIRT1), a class III histone deacetylase, has been identified as a candidate molecule affecting the epigenetic mechanisms of cardiovascular disease (CVD). Previous studies have shown that some SIRT1 single-nucleotide polymorphisms (SNPs) are associated with body mass index, diabetes, blood pressure, cholesterol metabolism and coronary artery calcification. We investigated two A>G SIRT1 SNPs, rs1467568 and rs7895833, in young South African (SA) Indians with coronary artery disease (CAD) and compared them to Indian and black controls.MethodsFor rs1467568, a total of 287 subjects were recruited into this study (104 CAD patients, 99 age-, gender- and race-matched controls, and 84 age- and gender-matched black controls). For rs7895833, a total of 281 subjects were recruited into this study (100 CAD patients, 99 age-, gender- and race-matched controls, and 82 age- and gender-matched black controls). All patients were male, of Indian ethnicity, stable CAD confirmed on angiography, mean age 37.5 years; range 24–45. All subjects were genotyped using TaqMan SNP genotyping assays.ResultsThe variant allele for both SNPs was found at a higher frequency in the total Indian group compared to the total black population (rs1467568: 41 vs 18.5%, respectively, p < 0.0001, OR = 3.190, 95% CI: 2.058–40943; and rs7895833: 41 vs 22%, respectively, p < 0.0001, OR = 2.466, 95% CI: 1.620– 3.755). Indian controls presented with a higher frequency for both SNPs compared to black controls (rs1467568: 40 vs 18.5%, respectively, p < 0.0001, OR = 2.996, 95% CI: 1.850– 4.853; and rs7895833: 41 vs 22%, respectively, p < 0.0001, OR = 2.513, 95% CI: 1.578–4.004). No difference was seen in the distribution of both SNPs between CAD patients and either control group. We did not observe any association between the SNPs and clinical parameters in CAD patients and controls.Conclusion:Both SNP variant alleles occurred more frequently in SA Indians than in SA blacks. A larger study group and further analysis is required to assess whether these SIRT1 SNPs may serve as risk factors that contribute to Indians developing early-onset CAD.

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“…SIRT1 (member of the sirtuin family) is a nicotinamide adenosine dinucleotide (NAD)-dependent deacetylase that removes acetyl groups from various proteins. It has been implicated that Sirt1 can impact a wide array of proteins, such as peroxisome proliferatoractivated receptor-gamma and its coactivator-1alpha, forkhead transcriptional factors, AMP-activated protein kinase, NF-kappaB and protein tyrosine phosphatase involved in cardiovascular and metabolic diseases, through regulating metabolic and physiologic processes including stress resistance, metabolism, apoptosis and energy balance (41)(42)(43). Notably, in the cardiovascular system, activation of SIRT1 can not only protect against oxidative stress at the cellular level, but can also elevate survival at the systemic level to reduce the risk of coronary heart disease and cerebrovascular disease (42).…”

Section: Discussionmentioning

confidence: 99%

Serum containing Buyang Huanwu decoction prevents age-associated migration and invasion of human vascular smooth muscle cells by up regulating SIRT1 expression

Zhang

Wei

Ruan

et al. 2018

BST

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SIRT1: Role in cardiovascular biology

Cited by 52 publications

References 133 publications

Long-term caloric restriction activates the myocardial SIRT1/AMPK/PGC-1α pathway in C57BL/6J male mice

Long-term caloric restriction activates the myocardial SIRT1/AMPK/PGC-1α pathway in C57BL/6J male mice

Sirtuin 1 rs1467568 and rs7895833 in South African Indians with early-onset coronary artery disease

Serum containing Buyang Huanwu decoction prevents age-associated migration and invasion of human vascular smooth muscle cells by up regulating SIRT1 expression

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