SIRT1 slows the progression of lupus nephritis by regulating the NLRP3 inflammasome through ROS/TRPM2/Ca2+ channel

Tian, Jihua; Huang, Taiping; Chen, Jingshu; Wang, Jing; Chang, Sijia; Xu, Huanyu; Zhou, Xiaoshuang; Yang, Jia; Xue, Yuan; Zhang, Tingting; Fan, Weiping; Wang, Yanhong

doi:10.1007/s10238-023-01093-2

Cited by 9 publications

(1 citation statement)

References 40 publications

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“…This may be achieved by inhibiting the NLRP3 inflammasome and sirtuin 1 signaling in the kidneys, thereby suppressing aberrant crosstalk between renal macrophages and tubular epithelial cells [207]. Subsequent studies have further elucidated the mechanism of the SIRT1-mediated negative regulation of NLRP3 inflammasome activation [208].…”

Section: Regulating Other Pathways Related To Nlrp3mentioning

confidence: 99%

New Potentiality of Bioactive Substances: Regulating the NLRP3 Inflammasome in Autoimmune Diseases

Chen,

Wang,

Chen

2023

Nutrients

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The NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome is an essential component of the human innate immune system, and is closely associated with adaptive immunity. In most cases, the activation of the NLRP3 inflammasome requires priming and activating, which are influenced by various ion flux signals and regulated by various enzymes. Aberrant functions of intracellular NLRP3 inflammasomes promote the occurrence and development of autoimmune diseases, with the majority of studies currently focused on rheumatoid arthritis, systemic lupus erythematosus and systemic sclerosis. In recent years, a number of bioactive substances have shown new potentiality for regulating the NLRP3 inflammasome in autoimmune diseases. This review provides a concise overview of the composition, functions, and regulation of the NLRP3 inflammasome. Additionally, we focus on the newly discovered bioactive substances for regulating the NLRP3 inflammasome in autoimmune diseases in the past three years.

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Section: Regulating Other Pathways Related To Nlrp3mentioning

confidence: 99%