2024
DOI: 10.1111/jcmm.18129
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SIRT2‐mediated deacetylation of ACLY promotes the progression of oesophageal squamous cell carcinoma

Xueying Zhang,
Yue Xu,
Shenglei Li
et al.

Abstract: ATP citrate lyase (ACLY), as a key enzyme in lipid metabolism, plays an important role in energy metabolism and lipid biosynthesis of a variety of tumours. Many studies have shown that ACLY is highly expressed in various tumours, and its pharmacological or gene inhibition significantly inhibits tumour growth and progression. However, the roles of ACLY in oesophageal squamous cell carcinoma (ESCC) remain unclear. Here, our data showed that ACLY inhibitor significantly attenuated cell proliferation, migration, i… Show more

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