SIRT3 deficiency is resistant to erastin-induced autophagy-dependent ferroptosis by inhibiting the AMPK/mTOR pathway and promoting glutathione peroxidase 4 levels
Abstract:Background: Ferroptosis, an autophagy-dependent cell death, is characterized by lipid peroxidation and iron accumulation, closely associated with pathogenesis of gestational diabetes mellitus (GDM). Sirtuin 3 (SIRT3) has positive regulation on phosphorylation of AMPK, related to maintainance of cellular redox homeostasis. However, whether SIRT3 can confer autophagy by activating the AMPK-mTOR pathway and consequently promote induction of ferroptosis is unknown. Methods: We used human trophoblastic cell line HT… Show more
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