SIRT3 expression in hepatocellular carcinoma and its impact on proliferation and invasion of hepatoma cells

Zhang, Bo; Qin, Lei; Zhou, Cuijie; Liu, Ye-Lu; Qian, Haixin; He, Songbing

doi:10.1016/s1995-7645(13)60112-1

Cited by 28 publications

(19 citation statements)

References 15 publications

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“…These results are agreement with several studies that refer to SIRT3 as an oncogene, since SIRT3 limits ROS production and increases cellular resistance to oxidative stress, thus promoting cell proliferation and avoiding apoptosis (Zhang, Ren, et al, ; Li, Li, Pei, Zhou, & Li, ). However, some studies describe SIRT3 as a tumor suppressor in some types of cancer, such as breast cancer (Buler, Aatsinki, Izzi, & Hakkola, ), ovarian cancer (Dong et al, ), hepatocellular carcinoma (Liu, Cheng, Yin, & Jiang, ; Zhang, Qin, et al, ) or B cell malignancies (Yu et al, ). In these reports, SIRT3 reduces cell proliferation of cancer cells and limits their metabolic reprogramming.…”

Section: Discussionmentioning

confidence: 99%

Sirtuin 3 silencing improves oxaliplatin efficacy through acetylation of MnSOD in colon cancer

Torrens‐Mas

Hernández-López

Oliver

et al. 2018

Journal Cellular Physiology

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Sirtuin 3 (SIRT3) is the major mitochondria deacetylase and regulates ROS levels by targeting several key proteins, such as those involved in mitochondrial function and antioxidant defenses. This way, SIRT3 balances ROS production and scavenging and promotes cell survival. The aim of this study was to analyze the effect of SIRT3 silencing on the antioxidant response in SW620 colon cancer cell line, and whether this intervention could improve efficacy of oxaliplatin, a common drug used to treat colon cancer. For this purpose, we obtained stable clones of SW620 with SIRT3 knockdown and determined parameters such as ROS levels and ROS production, levels of several antioxidant enzymes, cell viability, and apoptosis. Results showed that after SIRT3 silencing, both ROS levels and production were increased, and antioxidant enzymes gene expression was significantly reduced. Furthermore, manganese superoxide dismutase levels and enzymatic activity were reduced. Combination of SIRT3 knockdown with oxaliplatin treatment further increased ROS production and apoptosis, reducing cell viability. Finally, survival curves on colon cancer patients suggested that SIRT3 expression is related to a poorer prognosis. In conclusion, SIRT3 could be a target for colon cancer, since it regulates the antioxidant response and its knockdown improves the efficacy of oxaliplatin treatment.

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Section: Discussionmentioning

confidence: 99%

Sirtuin 3 silencing improves oxaliplatin efficacy through acetylation of MnSOD in colon cancer

Torrens‐Mas

Hernández-López

Oliver

et al. 2018

Journal Cellular Physiology

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show abstract

“…14 SIRT3 also minimizes ROS production at respiratory complex III 56 and enhances the anti-oxidant properties of mitochondrial superoxide dismutase (SOD2). [60][61][62][63][64][65][66] Interestingly, mRNA quantification demonstrated downregulation of SIRT1, SIRT2, SIRT3, SIRT5, SIRT6, and SIRT7 in head and neck squamous cell carcinoma. 59 SIRT3 was shown to control the Warburg effect of tumors through the destabilization of HIF-1α, a transcription factor that controls glycolytic gene expression.…”

Section: Mitochondrial Deacetylation Effects On Oxidative Stress and mentioning

confidence: 97%

Mitochondrial Acetylation and Genetic Models of Parkinson's Disease

Auburger

Gispert

Jendrach

2014

Progress in Molecular Biology and Translational Science

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“…In addition, reduced SIRT3 expression is suggested to be a biomarker for breast cancer associated with poor prognosis [50,51]. In addition to breast cancer, SIRT3 might play tumor suppressive roles in pancreatic cancer [52], hepatocellular carcinoma [53,54], B cell lymphoma cells [55], and metastatic ovarian cancer [56]. In addition, kaempferol, a flavonoid, increases SIRT3 expression and its mitochondrial import; hence, it stimulates apoptosis in leukemia cell lines [57].…”

Section: Changes In Sirtuin 3 Expression In Carcinogenesismentioning

confidence: 99%

Changes in the Expression and the Role of Sirtuin 3 in Cancer Cells and in Cardiovascular Health and Disease

Özden¹,

Tural²

2018

Gene Expression and Regulation in Mammalian Cells - Transcription Toward the Establishment of Novel Therapeutics

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Sirtuin 3, an NAD + -dependent deacetylase, whose expression is considered a marker in life extension, is downregulated with age and in various diseases. Sirtuin 3 is predominantly localized to the mitochondria and considered a fidelity protein for the integrity and function of this organelle. Some studies report its localization in the nucleus to regulate the expression of stress response-related genes and that reduced expression of SIRT3 produces a cellular milieu permissive for human pathologies. Since the expression and activity of Sirtuin 3 are important for the regulation of antioxidant defense, metabolism, and apoptosis initiation, the expression of SIRT3 is also important in the context of ageassociated illnesses. A variety of small molecules are being developed to modulate the expression or activity of Sirtuin 3 and are potentially a valuable strategy to change mitochondrial acetylome to treat several diseases. The AMPK-PGC1α-SIRT3 axis plays a critical role in preserving mitochondrial biogenesis and function. Here, we summarize how changes in Sirtuin 3 expression are regulated in cancer and dysfunctions in cardiovascular diseases. The potential therapeutic strategies by targeting Sirtuin 3 expression to improve mitochondrial function in cancer and cardiovascular diseases are summarized.

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SIRT3 expression in hepatocellular carcinoma and its impact on proliferation and invasion of hepatoma cells

Abstract: Abnormal expression of SIRT3 is closely related to the biological behavior of primary HCC.

Cited by 28 publications

References 15 publications

Sirtuin 3 silencing improves oxaliplatin efficacy through acetylation of MnSOD in colon cancer

Sirtuin 3 silencing improves oxaliplatin efficacy through acetylation of MnSOD in colon cancer

Mitochondrial Acetylation and Genetic Models of Parkinson's Disease

Changes in the Expression and the Role of Sirtuin 3 in Cancer Cells and in Cardiovascular Health and Disease

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